3.0T MRI arterial spin labeling and magnetic resonance spectroscopy technology in the application of Alzheimer's disease

Zou, Jianxun; Wang, Mingjie; Lei, Xinjun; Chen, Xu-Gao

doi:10.1016/j.exger.2014.09.009

Cited by 18 publications

(28 citation statements)

References 37 publications

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“…Findings from Dashjamts et al suggest that ASL imaging is better than morphological imaging (voxel-based grey matter density) in the diagnosis of AD [ 124 ], although Bron et al report no added diagnostic value of ASL over structural MRI atrophy markers in presenile dementia classification [ 125 ]. A number of studies utilise ASL as part of a multi-tool approach for elucidating AD-related changes, for instance alongside magnetic resonance spectroscopy [ 126 ] or hippocampal volume measurement [ 127 ]. Regional reduction of perfusion in AD is not necessarily related to other instances of neuropathological hypoperfusion.…”

Section: Clinical Applicationsmentioning

confidence: 99%

A neuroradiologist’s guide to arterial spin labeling MRI in clinical practice

et al. 2015

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Arterial spin labeling (ASL) is a non-invasive MRI technique to measure cerebral blood flow (CBF). This review provides a practical guide and overview of the clinical applications of ASL of the brain, as well its potential pitfalls. The technical and physiological background is also addressed. At present, main areas of interest are cerebrovascular disease, dementia and neuro-oncology. In cerebrovascular disease, ASL is of particular interest owing to its quantitative nature and its capability to determine cerebral arterial territories. In acute stroke, the source of the collateral blood supply in the penumbra may be visualised. In chronic cerebrovascular disease, the extent and severity of compromised cerebral perfusion can be visualised, which may be used to guide therapeutic or preventative intervention. ASL has potential for the detection and follow-up of arteriovenous malformations. In the workup of dementia patients, ASL is proposed as a diagnostic alternative to PET. It can easily be added to the routinely performed structural MRI examination. In patients with established Alzheimer’s disease and frontotemporal dementia, hypoperfusion patterns are seen that are similar to hypometabolism patterns seen with PET. Studies on ASL in brain tumour imaging indicate a high correlation between areas of increased CBF as measured with ASL and increased cerebral blood volume as measured with dynamic susceptibility contrast-enhanced perfusion imaging. Major advantages of ASL for brain tumour imaging are the fact that CBF measurements are not influenced by breakdown of the blood–brain barrier, as well as its quantitative nature, facilitating multicentre and longitudinal studies.

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Section: Clinical Applicationsmentioning

confidence: 99%

A neuroradiologist’s guide to arterial spin labeling MRI in clinical practice

et al. 2015

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“…ASL utilizes water in arteries as an endogenous contrast media to enable visualization of tissue perfusion, and can be used to quantify cerebral blood flow (CBF) without the need for radiation or intravenous injection [7]. Reduced CBF has been observed in AD patients, indicating that vascular factors play a critical role in the pathogenesis of the disease [8][9][10][11][12][13]. Several studies have also reported regional decreases in CBF in MCI patients prior to AD onset [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling

Wang

Ding

Zhao

et al. 2020

Aging

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We used pulsed arterial spin labeling (PASL) to investigate differences in cerebral blood flow (CBF) between 26 patients with amnestic mild cognitive impairment (aMCI) and 27 controls with normal cognition (NC). Hypoperfusion was observed in the right temporal pole of the middle temporal gyrus and the right inferior temporal gyrus in the aMCI compared with NC group. Interestingly, hyperperfusion was observed in the left temporal pole of the middle temporal gyrus, left superior temporal gyrus, bilateral precuneus, postcentral gyrus, right inferior parietal lobule, and right angular gyrus in the aMCI group, which likely resulted from a compensatory mechanism to maintain advanced neural activities. We found that mean CBF in the right inferior temporal gyrus, precuneus, and postcentral gyrus was positively correlated with cognitive ability in the aMCI but not NC group. Collectively, our data indicate that PASL is a useful noninvasive technique for monitoring changes in CBF and predicting cognitive decline in aMCI.

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“…Using the 3D-pcASL cerebral perfusion MRI technique, arterial blood flowing into the brain can be continuously labeled, 3D whole-brain fast imaging can be performed after labeling blood flowing into brain tissue, and finally, changes in the whole-brain blood flow can be detected. This technique has been widely used in clinical practice because of its advantages, such as being noninvasive, having repeatable functional imaging and being able to evaluate the whole brain without contrast agents [24–26]. Currently, there are many studies on the application of the 3D-pcASL perfusion MRI technique for adult brain examinations, but few studies exist on the application of the technique for child brain examinations, and very few studies exist on the application of the technique for neonatal brain examinations.…”

Section: Introductionmentioning

confidence: 99%

Application of a 3D pseudocontinuous arterial spin-labeled perfusion MRI scan combined with a postlabeling delay value in the diagnosis of neonatal hypoxic-ischemic encephalopathy

Tang

Liu

et al. 2019

PLoS ONE

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Background Currently, there are many studies on the application of the 3D pseudocontinuous arterial spin-labeled (3D-pcASL) perfusion MRI technique for adult brain examinations, but few studies exist on the application of the technique for child brain examinations. Purpose To explore the application of a 3D-pcASL perfusion MRI scan combined with postlabeling delay (PLD) for assessing neonatal hypoxic-ischemic encephalopathy (HIE). Materials and methods Two-hundred neonates diagnosed with neonatal HIE were equally divided into five groups (40/group): 0- to <24-hour-old HIE group, 1- to <3-day-old HIE group, 3- to <7-day-old HIE group, 7- to <15-day-old HIE group and 15- to 28-day-old HIE group; 200 healthy neonates were equivalently divided. All 10 groups received a conventional and a 3D-pcASL perfusion MRI scan. For groups <3 days old, PLD values for the 3D-pcASL cerebral perfusion MRI scan were preset at 1025 ms; in all other groups, PLD values were preset at 1525 ms. CBF values for the 3D-pcASL cerebral perfusion MRI were compared between the HIE and corresponding control groups to determine the distinguishing characteristics of CBF values in HIE neonates. Results On the 3D-pcASL cerebral perfusion MRI scan, in the 1- to <3-day-old groups, HIE neonate CBF values were higher than those of controls in all brain regions (excluding the frontal lobe); in the 0- to <24-hour-old and 3- to <7-day-old groups, HIE neonate CBF values were lower than those of corresponding controls in all brain regions; in the 7- to <15-day-old and 15- to 28-day-old groups, there were no significant differences in the CBF values between groups in any brain regions. Conclusions The 3D-pcASL perfusion MRI scan combined with a PLD can assist in the early diagnosis of neonatal HIE, as this method more comprehensively reflects the HIE pathological process.

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3.0T MRI arterial spin labeling and magnetic resonance spectroscopy technology in the application of Alzheimer's disease

Cited by 18 publications

References 37 publications

A neuroradiologist’s guide to arterial spin labeling MRI in clinical practice

A neuroradiologist’s guide to arterial spin labeling MRI in clinical practice

Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling

Application of a 3D pseudocontinuous arterial spin-labeled perfusion MRI scan combined with a postlabeling delay value in the diagnosis of neonatal hypoxic-ischemic encephalopathy

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