Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling

Wang, Xiang-Bin; Ding, Ding; Zhao, Qianhua; Liang, Xiaoniu; Peng, Long; Zhao, Xiaofeng; Xi, Qi; Zhang, Min; Wang, Wei; Xu, Xin; Guo, Qihao; Wang, Peijun

doi:10.18632/aging.102888

Cited by 5 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A compensatory mechanism to maintain advanced neural activities by increasing blood oxygen and energy metabolism may also explain the relationship between gray matter hyperperfusion and mild cognitive impairment. 54 Supporting the hypothesis of a compensatory mechanism in the present study, activated flow during tasks has been reported to be lower in those doing well on cognitive tasks in normotensive individuals but with higher BP and BMI. 55,56 It is thus possible that, in our cohort, a higher CBF in treated hypertensive patients is associated with end-organ damages or compensatory mechanisms to maintain neural activities.…”

Section: Is Rmbp a Predictor Of Cognitive Performance Independently O...supporting

confidence: 89%

Associations Between Relative Morning Blood Pressure, Cerebral Blood Flow, and Memory in Older Adults Treated and Controlled for Hypertension

et al. 2021

View full text Add to dashboard Cite

Hypertension, elevated morning blood pressure (BP) surges, and circadian BP variability constitute risk factors for cerebrovascular events. Nevertheless, while evidence indicates that hypertension is associated with cognitive dysfunctions, the link between BP variability and cognitive performance during aging is not clear. The purpose of this study is to determine the interaction between relative morning BP, cerebral blood flow (CBF) levels, and cognitive performance in hypertensive older adults with controlled BP under antihypertensive treatment. Eighty-four participants aged between 60 and 75 years old were separated into normotensive (n=51) and hypertensive (n=33) groups and underwent 24-hour ambulatory BP monitoring. They were also examined for CBF in the gray matter (CBF-GM) by magnetic resonance imaging and 5 cognitive domains: global cognition, working memory, episodic memory, processing speed, and executive functions. There was no difference in cognitive performance and CBF between normotensive and controlled hypertensive participants. Through a sensitivity analysis, we identified that, among relative morning BP variables, the best fit for CBF values in this cohort was the morning-evening difference in BP. The relative morning BP was negatively associated with CBF-GM in these hypertensive older adults only. In turn, CBF-GM levels were negatively associated with working and episodic memory scores in hypertensive older adults. This is the first extended study demonstrating an association between high relative morning BP and lower levels of CBF-GM, including the further impact of CBF-GM levels on the cognitive performance of specific domains in a community-based cohort of older adults with hypertension.

show abstract

Section: Is Rmbp a Predictor Of Cognitive Performance Independently O...supporting

confidence: 89%

Associations Between Relative Morning Blood Pressure, Cerebral Blood Flow, and Memory in Older Adults Treated and Controlled for Hypertension

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Two articles described the same data set, one of which was excluded. Thirteen articles were finally included (Johnson et al, 2005 ; Xu et al, 2007 ; Alexopoulos et al, 2012 ; Wierenga et al, 2012 ; Kim et al, 2013 ; Ding et al, 2014 ; Okonkwo et al, 2014 ; Lv et al, 2015 ; Michels et al, 2016 ; Shokouhi et al, 2018 ; Duan et al, 2020 ; Wang et al, 2020 ; Shang et al, 2021 ), including 12 papers in English and one paper in Chinese, as shown in Figure 1 (literature screening flow chart).…”

Section: Resultsmentioning

confidence: 99%

“…The presence of hyperperfusion in the LN in MCI patients may be related to compensatory mechanisms. The brain maintains higher neural activity by increasing blood oxygen and energy metabolism (Howarth, 2014 ; Wang et al, 2020 ). One study found that the mean CBF of the precuneus and postcentral gyrus in the aMCI group was positively correlated with cognitive level, but the result was not applicable in the control group (Wang et al, 2020 ), which laterally demonstrated the existence of compensatory mechanisms in MCI patients.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies apply ASL to examine perfusion in MCI (Xie et al, 2019 ; Camargo and Wang, 2021 ). In a resting-state condition, parietal (Johnson et al, 2005 ; Alexopoulos et al, 2012 ; Wierenga et al, 2012 ; Lou et al, 2016 ), hippocampal (Kim et al, 2013 ; Okonkwo et al, 2014 ; Duan et al, 2020 ; Camargo and Wang, 2021 ), and temporal lobes (Wierenga et al, 2012 ; Ding et al, 2014 ; Wang et al, 2020 ; Camargo and Wang, 2021 ) often showed an abnormal perfusion in patients with MCI as compared with healthy control (HC). However, results across the studies are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging

Tang

Huang²,

Zhang³

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

In mild cognitive impairment (MCI), cognitive decline is associated with abnormal changes of cerebral blood flow (CBF). Arterial spin labeling magnetic resonance imaging (ASL-MRI) is an effective method for assessing regional cerebral blood flow (rCBF). However, the CBF estimated via ASL-MRI in MCI often differs between studies, and the consistency of CBF changes in MCI is unclear. In this study, 13 ASL-MRI studies with 495 MCI patients and 441 health controls were screened out from PubMed, Embase, Cochrane, Web of Science, Wanfang, and CNKI. An activation likelihood estimation (ALE) meta-analysis was performed to explore the brain regions with abnormal CBF in MCI. It showed that the decreased CBF in MCI was identified in the precuneus, inferior parietal lobule (IPL), superior occipital gyrus (SOG), middle temporal gyrus (MTG), and middle occipital gyrus (MOG), while the increased CBF in MCI was identified in the lentiform nucleus (LN) compared with healthy controls. The study characterized the abnormal pattern of regional CBF in MCI, which would promote our knowledge of MCI and might be used as a biomarker in clinic.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=259633.

show abstract

“…A resting-state fMRI study showed synchronal abnormalities in the ITG and MTG of depressive patients who also have anxiety (Li et al, 2018). The ITG and MTG are also anoxia-sensitive regions, and hypoperfusion in the ITG and MTG was observed in amnestic mild cognitive impairment (aMCI), indicating impaired blood oxygen (Wang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Preliminary Study of Subclinical Brain Alterations in Patients With Asymptomatic Carotid Vulnerable Plaques Using Intravoxel Incoherent Motion Imaging by Voxelwise Comparison: A Study of Whole-Brain Imaging Measures

et al. 2020

View full text Add to dashboard Cite

ObjectiveTo preliminarily explore subclinical brain alterations in an asymptomatic carotid vulnerable plaque group based on intravoxel incoherent motion (IVIM) imaging through voxelwise comparison in the whole brain.Materials and MethodsForty-nine elderly participants underwent multi-b-value DWI, of whom 24 participants with asymptomatic carotid vulnerable plaques and <50% stenosis served as the test group, while the rest served as the healthy control group. After fitting the double-exponential model, slow ADC (Ds) and the fraction of fast ADC (f) values of the whole brain were obtained, which then were compared in a voxelwise manner by two-sample t-test. Multiple comparisons were corrected by the family-wise error (FWE) method with a corrected threshold of P < 0.05. Pearson correlations between IVIM parameters in altered brain regions and blood pressure, glucose, lipid, and homocysteine were calculated.ResultsFor the test group, the Z-normalized Ds values were significantly higher in the left median cingulate and paracingulate gyrus (DCG.L), posterior cingulate gyrus (PCG. L), and left precuneus gyrus (PCUN.L) (cluster size = 156) and in the left middle frontal gyrus (MFG.L), orbital middle frontal gyrus (ORBmid.L), and superior frontal gyrus (SFG.L) (cluster size = 165); the Z-normalized Ds values were significantly lower in the right middle temporal gyrus (MTG.R) and inferior temporal gyrus (ITG.R) (cluster size = 116); and the Z-normalized f-values were significantly lower in the MTG.R and ITG.R (cluster size = 85) (p < 0.05, FWE correction). LDL-C was negatively correlated with the Z-normalized Ds values in the DCG.L, PCG.L, and PCUN.L (r = 0.601, p = 0.002). LDL-C was positively correlated with the Z-normalized f-value in the MTG.R and ITG.R (r = 0.405, p = 0.05). Systolic blood pressure was positively correlated with the Z-normalized Ds values in the MFG.L, ORBmid.L, and SFG.L (r = 0.433, p = 0.035).ConclusionThis study was the first to detect subclinical brain alterations in asymptomatic carotid vulnerable plaque group through IVIM using whole-brain voxelwise comparisons, which were partially correlated with blood pressure and lipids. Thus, IVIM might be utilized as a noninvasive biomarker of microvascular and microstructural brain changes in the asymptomatic carotid vulnerable plaque group.

show abstract

Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling

Cited by 5 publications

References 46 publications

Associations Between Relative Morning Blood Pressure, Cerebral Blood Flow, and Memory in Older Adults Treated and Controlled for Hypertension

Associations Between Relative Morning Blood Pressure, Cerebral Blood Flow, and Memory in Older Adults Treated and Controlled for Hypertension

Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging

Preliminary Study of Subclinical Brain Alterations in Patients With Asymptomatic Carotid Vulnerable Plaques Using Intravoxel Incoherent Motion Imaging by Voxelwise Comparison: A Study of Whole-Brain Imaging Measures

Contact Info

Product

Resources

About