3′‐(2,4‐Dinitrobenzenesulfonyl)‐2′,7′‐dimethylfluorescein as a Fluorescent Probe for Selenols

Abstract

Simply the BESThio: The fluorescein derivative BESThio (see scheme) operates as a thiol probe at pH 7.4 and functions as a selenol probe at pH 5.8, and can thus be selectively applied to the rapid quantification of selenocysteine and the determination of the selenocysteine content in selenoproteins such as glutathione peroxidase and thioredoxin reductase with high sensitivity.

Construction of a Near‐Infrared Fluorescent Turn‐On Probe for Selenol and Its Bioimaging Application in Living Animals

“…However, designing highly selective probes for Sec without suffering from interference of biological thiols is challenging since thiols are usually present in high concentration (millimolar levels) in cells and have similar chemical properties as Sec. Some fluorescent probes for Sec have been achieved by taking advantage of the mechanism of nucleophilic aromatic substitution 6. 7 However, these reported fluorescent probes for Sec are located in the visible region and are only suitable for imaging studies in living cells.…”

Room temperature long-lived triplet excited state of fluorescein in N^N Pt(II) bisacetylide complex and its applications for triplet–triplet annihilation based upconversions

“…In order to exclude the undesired effect of the lactum/lactone structure of the fluorescein on the photophysics of the complex Pt-1 (Scheme 1) [3,4], we used an acetylide ligand that without the carboxylic moiety (L-1, Scheme 1). 8-Bromobenzenealdehyde and m-dihydroxylbenzene were used as the starting materials.…”

A new ensemble approach based chemosensor for the reversible detection of bio-thiols and its application in live cell imaging

“…In the last two decades, enormous efforts have been devoted to the development of fluorescent chemosensors for the detection of thiols based on various chemical mechanisms, such as Michael addition [16][17][18], cyclization with aldehyde [19][20][21], disulfide bond cleavage reaction [22,23], binding with nanoparticles [24,25], cleavage of sulfonamide and sulfonate ester [26][27][28][29][30]. Recently, chemosensing ensemble-based displacement approach has been reported as one of new mechanisms for the thiols detection [31][32][33][34][35][36][37][38][39][40].…”