3 : 21-Dihydroxypregn-5-ene-20-one in Urine of Normal Newborn Infants and in Third Day Urine of Child with Deficiency of 3 -hydroxysteroid-dehydrogenase

A Difficulty in Confirming 21 Hydroxylase Deficiency in a Neonate With Congenital Adrenal Hyperplasia

“…The presence of at least 6 reducing steroids, presumably conjugated as sulphates, suggested that one or more of the pathways to glucocortocoid synthesis was partially open. The tentative identification of 21hydroxypregnenolone ( Figure 4) within this group, gives support to the supposed pathway that is open in the neonatal period as described by Cathro et al (1965). However, the steroids formed along this pathway are quantitatively more significant in those patients with 3P-01-dehydrogenase deficiency than in norman neonates.…”

“…Other metabolites have been found, notably 1 I-oxypregnanetriol, this metabolite occurring more often in the youngest of the infants (Finkelstein, 1959). The observations of Cathro et al (1963Cathro et al ( , 1965, that patterns of steroids can be found in the urine of normal neonates which are similar to those found in the urine of children with the rare form of congenital adrenal hyperplasia ( 3P-01-dehydrogenase deficiency) has directed attention towards the subtle differences in steroid metabolism in the neonatal period as compared to later life.…”

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

“…Studies of the rate of cortisol secretion (Aarskog, 1963(Aarskog, , 1965Kenny, Precyasombat, Migeon, Laurence & Richards, 1966) in the newborn suggest that at least during the first few days of life, the normal baby produces more cortisol relative to his total body surface than does the adult. This difference between the data on cortisol production and urinary excretion is accounted for by the unique pattern of cortisol metabolism in the immediate post-natal period (Migeon, 1959;Ulstrom et al 1960 a, b;Reynolds Colle & Ulstrom, 1962;Reynolds, 1963;Kenny, Malvaux & Migeon, 1963;Cathro, Birchall, Mitchell & Forsyth, 1965). These findings contrast with the results of measurements of the urinary excretion of 17-hydroxycorticosteroids which, corrected for surface area, have been shown to be lower in the normal newborn than in infants 5-20 days of age (Kenny et al 1966).…”

Relationship between Maternal Progesterones and the Delayed Drug Metabolism in the Neonate

“…It is possible, therefore, that the delayed development of drug metabolizing enzymes in the newborn infant is also associated with these reduced progesterone metabolites. The level of these metabolites in the fetus and newborn in the 1st day of life is also high [20], and the excretion and metabolism of these steroids is low [23][24][25][26]. In addi tion, the quantities of these reduced derivatives are being re-established by their intake in mother's milk.…”