2017
DOI: 10.7150/thno.18082
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3,3′-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing

Abstract: Human umbilical cord-derived mesenchymal stem cells (hucMSCs) are suggested as a promising therapeutic tool in regenerative medicine, however, their efficacy requires improvement. Small molecules and drugs come up to be a convenient strategy in regulating stem cells fate and function. Here, we evaluated 3,3′-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model. HucMSCs primed with 50 μM of DIM exhibited desirable re… Show more

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Cited by 92 publications
(79 citation statements)
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References 62 publications
(58 reference statements)
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“…Ruan et al revealed that Suxiao Jiuxin Pill, a type of traditional Chinese medicine, could promote mouse BMSC-EV secretion [88]. Our study revealed that 3,3 -Diindolylmethane-stimulated hucMSCs secreted Wnt11-overexpressing EVs that could be used to improve wound healing in rats [51]. In addition, Kulkarni et al noted that aging BMSCs treated with AKT signal inhibitor LY294002 reduced exosomal miR-17 and miR-34a, and both downregulated autophagy-associated mRNA expression in recipient cells [86].…”
Section: Drug Preconditioning and Inflammatory Stimulimentioning
confidence: 53%
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“…Ruan et al revealed that Suxiao Jiuxin Pill, a type of traditional Chinese medicine, could promote mouse BMSC-EV secretion [88]. Our study revealed that 3,3 -Diindolylmethane-stimulated hucMSCs secreted Wnt11-overexpressing EVs that could be used to improve wound healing in rats [51]. In addition, Kulkarni et al noted that aging BMSCs treated with AKT signal inhibitor LY294002 reduced exosomal miR-17 and miR-34a, and both downregulated autophagy-associated mRNA expression in recipient cells [86].…”
Section: Drug Preconditioning and Inflammatory Stimulimentioning
confidence: 53%
“…Our team discovered that hucMSC-EXs transported the Wnt4 protein to activate Wnt/β-catenin signaling and facilitate angiogenesis in a rat model of deep second-degree burn injury, thus shortening wound healing times [50]. We further found that hucMSCs pretreated with a small-molecule drug, 3,3 -diindolylmethane, displayed increasing exosomal Wnt11 autocrine signaling, cell activity, and differentiation potential, eventually leading to a better repair effect in the same model [51].…”
Section: Skinmentioning
confidence: 94%
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“…MSC from adipose tissue or from umbilical cord MSCs are less invasive to obtain and can be isolated at a lower cost compared with bone marrow derived MSC. They retain the multipotency and immunoregulatory activities, as well as the functional outcomes observed with bone-marrow derived MSC (1,6). …”
mentioning
confidence: 99%
“…These cells are tightly regulated by cytokines, growth factors, and extracellular matrix molecules [7][8][9]. Although recombinant growth factors and cytokines have been clinically applied in treating skin damage, disadvantages in their use include their easy degradation and instability in vitro [10,11], and the highest clinical cure rate remains at 50-60% [12]. Therefore, it is necessary to identify novel biological products with low cost and easy storage.…”
Section: Introductionmentioning
confidence: 99%