3,4-Dihydroxybenzaldehyde mitigates fluoride-induced cytotoxicity and oxidative damage in human RBC

Anjum, Rubi; Maheshwari, Nikhil; Mahmood, Riaz

doi:10.1016/j.jtemb.2021.126888

Cited by 10 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress refers to a state of imbalance between antioxidants and free radicals, which is dynamically regulated by the antioxidant enzymes, including GPX, SOD, and CAT ( Ávila-Escalante et al, 2020 ; Sadasivam et al, 2022 ). Lipid peroxides (such as MDA) can damage cells and induce apoptosis by producing free radicals, and its cytotoxicity can also affect the activity of various enzymes and ATP synthesis ( Anjum et al, 2022 ; Qi et al, 2022 ; He et al, 2023 ). Our study showed that dietary supplementation with BL significantly increased the levels of T-AOC and GPX, and promoted the activities of CAT and SOD in the serum of broilers.…”

Section: Discussionmentioning

confidence: 99%

Effects of Bacillus licheniformis on growth performance, immune and antioxidant functions, and intestinal microbiota of broilers

Qin,

Xiao,

Dai

et al. 2024

Poultry Science

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Effects of Bacillus licheniformis on growth performance, immune and antioxidant functions, and intestinal microbiota of broilers

Qin,

Xiao,

Dai

et al. 2024

Poultry Science

View full text Add to dashboard Cite

“…The plant antioxidant 3,4-dihydroxybenzaldehyde (3,4-DHB) protected against pentachlorophenol (PCP)-induced cytotoxicity and genotoxicity in human red blood cells (RBC) and lymphocytes [28]. Anjum et al demonstrated that 3,4-dihydroxybenzaldehyde (3,4-DHB) significantly and dose-dependently mitigated sodium fluoride (NaF)-induced oxidative modifications [29].…”

Section: 4-dihydroxybenzaldehyde (34-dhb)mentioning

confidence: 99%

“…Inhibited B16-F10 cancer cell migration by inhibition of EMT [18] 3,4-dihydroxybenzaldehyde Anti-neuroinflammatory effects in rat models of middle cerebral artery occlusion/reperfusion and lipopolysaccharide (LPS)-treated BV2 microglial cells [27] Inhibits oxidative DNA damage in human blood cells [28,29]…”

Section: Sinensol C Inhibits Adipogenesis In 3t3-l1 Cells (Upregulati...mentioning

confidence: 99%

Pharmacological and Chemical Potential of Spiranthes sinensis (Orchidaceae): A Narrative Review

Kuo

Pei

Chao

2022

Plants

View full text Add to dashboard Cite

Orchidaceae is one of the largest families of flowering plants with more than 27,000 accepted species, and more than 31,000–35,000 species are estimated to exist in total. The orchid Spiranthes sinensis (Pers.) Ames, having ornamental and medicinal value, is widely distributed throughout Asia and Oceania. S. sinensis (Shou Tsao) is also known as Panlongshen among the common folk herbs. It has a fleshy root similar to ginseng, and the entire plant is widely used in traditional Chinese medicine. Owing to overexploitation and habitat destruction in recent years, the wild population has become scarce. The traits of this species show obvious differences in different countries. In the Taiwanese climate, it flowers during the Ching Ming Festival, also called the ching ming tsao. Previous investigations into S. sinensis have revealed the presence of flavonoids, homocyclotirucallane, dihydrophenanthrenes, ferulic acid, and 3,4-dihydroxybenzaldehyde. Phenolic constituents of structural and biological interest, including phenanthrenes and flavonoids, have been isolated and identified from S. sinensis. This natural product possesses extensive bioactivity, including anti-tumor, anti-inflammatory, and antioxidant effects. In this review, we outline the herbal medicine formulations and plant-derived natural products of S. sinensis.

show abstract

Novel Mannich Bases of α‐Mangostin Bearing Methoxyphenyl Moieties with Antioxidant and Membrane‐protective activity

Буравлев

Шевченко

2022

ChemistrySelect

View full text Add to dashboard Cite

A series of novel Mannich bases containing (monomethoxy-, dimethoxy-or trimethoxy)phenyl substituent and morpholine fragment have been synthesized via C-4-monoaminomethylation of α-mangostin, a natural hydroxyxanthone. This modification has led to a considerable reduction in erythrotoxicity of natural xanthone while preserving its high antioxidant activity. All synthesized derivatives have demonstrated higher radical scavenging activity and total antioxidant activity compared to those of α-mangostin, several compounds have also shown higher efficacy in the test system with red blood cells. In the model of oxidative hemolysis of red blood cells induced by hydrogen peroxide and 2,2'-azobis(2-amidinopropane) dihydrochloride, a Mannich base containing 3,4,5trimethoxyphenyl substituent has been shown to have the highest membrane-protective and antioxidant activity.

show abstract

3,4-Dihydroxybenzaldehyde mitigates fluoride-induced cytotoxicity and oxidative damage in human RBC

Cited by 10 publications

References 49 publications

Effects of Bacillus licheniformis on growth performance, immune and antioxidant functions, and intestinal microbiota of broilers

Effects of Bacillus licheniformis on growth performance, immune and antioxidant functions, and intestinal microbiota of broilers

Pharmacological and Chemical Potential of Spiranthes sinensis (Orchidaceae): A Narrative Review

Novel Mannich Bases of α‐Mangostin Bearing Methoxyphenyl Moieties with Antioxidant and Membrane‐protective activity

Contact Info

Product

Resources

About