This paper presents a compact, energy-efficient and low-power Wheatstone bridge temperature sensor for biomedical applications. To maximize sensitivity and reduce power dissipation, the sensor employs a high-resistance (600k) bridge that consists of resistors with positive (silicided-poly) and negative (n-poly) temperature coefficients. Resistor spread is then mitigated by trimming the n-poly arms with a 12-bit DAC, which consists of a 5-bit series DAC whose LSB is trimmed by a 7-bit PWM generator. The bridge is readout by a 2 nd -order delta-sigma modulator, which dynamically balances the bridge by tuning the resistance of the silicided-poly arms via a 1-bit series DAC. As a result, the modulator's bitstream average is an accurate and near-linear function of temperature, which does not require further correction in the digital domain. Fabricated in a 180nm CMOS technology, the sensor occupies 0.12mm 2 . After a 1-point trim, it achieves +0.2°C/−0.1°C (3σ) inaccuracy in a ±10°C range around body temperature (37.5°C). It consumes 6.6μW from a 1.6V supply, and achieves 200μK resolution in a 40ms conversion time, which corresponds to a state-of-the-art resolution FoM of 11fJ•K 2 . Duty-cycling the sensor results in even lower average power: 700nW at 10 conversions/s.