3-Acetyl-11-keto-β-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity

Goel, Amit; Ahmad, Feroz; Singh, Rohit; Singh, Gyanendra

doi:10.1211/jpp.62.02.0016

Cited by 40 publications

(22 citation statements)

References 26 publications

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“…3-Acetyl-11-keto-beta-boswellic acid (AKBA), which is well known for anti-inflammatory activity, also has antiarthritic activity. (5) Topical application of the polymeric nanomicelles of AKBA showed potent anti-inflammatory and antiarthritic activities [22]. …”

Section: Herbal Products Used To Treat or Prevent Arthritismentioning

confidence: 99%

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Nanjundaiah

Astry

Moudgil

2013

Evidence-Based Complementary and Alternative Medicine

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints leading to bone and cartilage damage. Untreated inflammatory arthritis can result in severe deformities and disability. The use of anti-inflammatory agents and biologics has been the mainstay of treatment of RA. However, the prolonged use of such agents may lead to severe adverse reactions. In addition, many of these drugs are quite expensive. These limitations have necessitated the search for newer therapeutic agents for RA. Natural plant products offer a promising resource for potential antiarthritic agents. We describe here the cellular and soluble mediators of inflammation-induced bone damage (osteoimmunology) in arthritis. We also elaborate upon various herbal products that possess antiarthritic activity, particularly mentioning the specific target molecules. As the use of natural product supplements by RA patients is increasing, this paper presents timely and useful information about the mechanism of action of promising herbal products that can inhibit the progression of inflammation and bone damage in the course of arthritis.

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Section: Herbal Products Used To Treat or Prevent Arthritismentioning

confidence: 99%

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Nanjundaiah

Astry

Moudgil

2013

Evidence-Based Complementary and Alternative Medicine

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“…For the treatment of arthritis and to reduce inflammation, a higher concentration of drug is required at the site of inflammation, which could be achieved by topical application directly on the target tissue [1] . The literature of Ayurveda describes various plants, to be used as whole, in parts or as extract for treating painful and inflammatory conditions like arthritis.…”

Section: Research Papermentioning

confidence: 99%

“…Many studies have demonstrated that molecules with intermediate lipophilicity (log P, o/w of 2-3) can permeate via both the lipid and polar micro environments within the intercellular route [6] . To overcome the drawback of high lipophilicity, B. serrata has been formulated as nanoemulsion [7] , nanomicelle [1] and nanogel [8] so as to enhance permeability on topical application.…”

Section: Research Papermentioning

confidence: 99%

Topical Nanoemmigel Formulation of Boswellia serrata

Harsha¹,

Shreya²

2018

pharmaceutical-sciences

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Kathpalia and Shreya: Boswellia serrata NanoemmigelBoswellia serrata was formulated as topical analgesic and antiinflammatory nanoemmigel, which is a combination of a nanoemulsion and a nanomicellar system in a gel base. Nanoemulsion was formulated by microemulsion-template method by using probe sonication at 5 amp for 5 min. Particle size of nanoemulsion was found to be 141 nm and polydispersity index of 0.333. Nanomicelle was formulated at a ratio 1:1 of drug and surfactant and 1:10 of solvent and antisolvent using solvent evaporation method. The particle size and polydispersity index of the nanomicelle was found to be 31.07 nm and 0.205, respectively. Nanoemmigel was prepared by combining nanoemulsion and nanomicelle in the ratio 1:1 with Carbopol 974 as a gelling agent. The nanoemmigel prepared was a buff-coloured, opaque gel with smooth texture and good spreadability. Viscosity and drug content of the nanoemmigel was 50720 cps and 103±1.08 %, respectively. In vitro diffusion study of nanoemmigel showed 98.52±1.53 % drug permeation at the end of 5 h. The drug release mechanism of the nanoemmigel formulation can be explained using the Higuchi model. The steady state flux and permeability co-efficient of the nanoemmigel was found to be better than each of nanoemulsion gel and nanomicellar gel due to the utilization of both the pathways available to the drug for permeation through the skin. Improved therapeutic response was obtained as compared to nanoemulsion gel, nanomicellar gel, emulgel and also marketed topical product of Boswellia when examined for in vivo antiinflammatory and analgesic activity in animal models

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“…NPs and nanomicelles can also act as carriers for drugs, which can be contained into organic nanomicelles or porous inorganic NPs that, by apt bioactive systems, can target tumoral cells of the body (see Yao et al, 2011;Goel et al, 2010) …”

Section: Nanoparticles In Biomedicinementioning

confidence: 99%

Emerging nanotechnological research for future pathways of biomedicine

Coccia

Finardi

2012

IJBNN

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Abstract:The purpose of this paper is to measure and analyse the rate of scientific and technological advance of some emerging nanotechnological research fields in biomedicine to detect path-breaking technological trajectories. The approach, based on exponential models of growth, shows the current evolutionary trends of nano-research that may underpin future patterns of technological innovation in biomedicine and nanomedicine. In particular, results show that biosensors, quantum dots, carbon nanotubes and nanomicelles have innovative applications in diagnostics and targeted therapies for cancers that have been generating a revolution in clinical practice. The present study also detects two main determinants that have been supporting continuous diffusion of nano-technology in biomedicine: convergence of genetics, genomics and nanotechnology and multiplicity of learning processes in clinical research/practice. These drivers have been paving groundbreaking pathways in biomedicine that can lead to longer, better and healthier living of societies in not-too-distant future.

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3-Acetyl-11-keto-β-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity

Abstract: This study suggested that AKBA polymeric nanomicelle gel significantly enhanced skin permeability, and anti-inflammatory and anti-arthritic activity.

Cited by 40 publications

References 26 publications

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Topical Nanoemmigel Formulation of Boswellia serrata

Emerging nanotechnological research for future pathways of biomedicine

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