3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents

Kuarm, B. Suresh; Reddy, Y. Thirupathi; Madhav, J. Venu; Crooks, Peter A.; Rajitha, B.

doi:10.1016/j.bmcl.2010.10.082

Cited by 81 publications

(41 citation statements)

References 32 publications

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“…Cellulose sulfuric acid (Catalyst)/ DMF MWI (5-6 min, 91-97%) Antibacterial and antifungal [66] 9-Aryl-6-chloropurines (59) Trimethylorthoformate in acetic anhydride (MWI, 120 °C, 1 h).…”

Section: -[Benzimidazo(12-c)quinazolin-5-yl]-2h-chromene-2-one (57)mentioning

confidence: 99%

Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

Bandyopadhyay¹,

Banik²

2015

Green Synthetic Approaches for Biologically Relevant Heterocycles

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“…Cellulose sulfuric acid (Catalyst)/ DMF MWI (5-6 min, 91-97%) Antibacterial and antifungal [66] 9-Aryl-6-chloropurines (59) Trimethylorthoformate in acetic anhydride (MWI, 120 °C, 1 h).…”

Section: -[Benzimidazo(12-c)quinazolin-5-yl]-2h-chromene-2-one (57)mentioning

confidence: 99%

Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

Bandyopadhyay¹,

Banik²

2015

Green Synthetic Approaches for Biologically Relevant Heterocycles

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“…FDA has approved several quinazoline derivatives as anticancer drugs, such as Gefitinib, Erlotinib, Lapatinib and Vandetanib 9 . Moreover, a series of triazol-4-ylsubstituted quinazolines and 2-thio- [1,2,4]triazolo [1,5-c]quinazoline derivatives have been identified as potent antimicrobial agents 27 . Therefore, the development of a novel and efficient anticancer agent that can be used for prophylaxis as well as the treatment of bacterial infections in cancer patients remains an important goal in medicinal chemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies

Alanazi

Abdel‐Aziz

Shawer

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Some new derivatives of substituted-4(3H)-quinazolinones were synthesized and evaluated for their in vitro antitumor and antimicrobial activities. The results of this study demonstrated that compound 5 yielded selective activities toward NSC Lung Cancer EKVX cell line, Colon Cancer HCT-15 cell line and Breast Cancer MDA-MB-231/ATCC cell line, while NSC Lung Cancer EKVX cell line and CNS Cancer SF-295 cell line were sensitive to compound 8. Additionally, compounds 12 and 13 showed moderate effectiveness toward numerous cell lines belonging to different tumor subpanels. On the other hand, the results of antimicrobial screening revealed that compounds 1, 9 and 14 are the most active against Staphylococcus aureus ATCC 29213 with minimum inhibitory concentration (MIC) of 16, 32 and 32 mg/mL respectively, while compound 14 possessed antimicrobial activities against all tested strains with the lowest MIC compared with other tested compounds. In silico study, ADME-Tox prediction and molecular docking methodology were used to study the antitumor activity and to identify the structural features required for antitumor activity.

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“…The current interest in 4H-chromene derivatives arises from their potential application as antimicrobial (Kuarm et al, 2011;Rai et al, 2010), anti-HIV (Bhavsar et al, 2011;Park et al, 2008), anti tubercular (Kamdar et al, 2010), antioxidant (Singh et al, 2010), anticancer (Raju et al, 2011), antitumor (Huang et al, 2009), cytotoxic agent (Raj et al, 2010;Sabry et al, 2011), antidyslipidemic agent (Sashidhara et al, 2008), antileishmanial (Nazarian et al, 2010), anti inflametory (Gebhardt et al, 2007), antihelicobacter pylori agent (Chimenti et al, 2007), and TNF-a inhibitor (Cheng et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis of 3′-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

Kathrotiya

Patel

2011

Med Chem Res

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A new series of indole-based chromene derivatives 4a-4p has been synthesized by one pot cyclocondensation reaction of 2-phenyl-1H-indole-3-carbaldehyde 1a-1h; malononitrile 2; and 1,3-cyclohexanedione/dimedone 3a/b under microwave irradiation catalyzed by an organocatalyst 4-(N,N-dimethylamino) pyridine. Easy experimental procedure, high yield, selectivity, and shorter reaction time are the imperative features of this method. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than that of standard drugs as evident from SAR study.

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3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents

Cited by 81 publications

References 32 publications

Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies

Microwave-assisted synthesis of 3′-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

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