3-Butenyl isothiocyanate: a hydrolytic product of glucosinolate as a potential cytotoxic agent against human cancer cell lines

Arora, Rohit; Kumar, Rajeev; Mahajan, Jyoti; Vig, Adarsh Pal; Singh, Bikram; Singh, Balbir; Arora, Saroj

doi:10.1007/s13197-016-2316-7

Cited by 30 publications

(19 citation statements)

References 26 publications

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“…There are a few studies on the effects of 3-BI on cancer cells under in vitro conditions (26,30,35). Other 3-butenyl ITCs, including 4-methylthio-3-BI-ITC (raphasatin) or 4-methylsulfinyl-3-BI-ITC (sulforaphene), have been found not to cause toxicity in T lymphocytes, despite being cytotoxic in Unlike other ITCs, the molecular mechanisms by which 3-BI produces an inhibitory effect on the survival and proliferation of cancer cells are not fully known.…”

Section: Discussionmentioning

confidence: 99%

“…1). ITCs have inhibitory effects on the metabolic activation of carcinogenic dietary or tobacco components (24), along with the inhibition of mutagenesis (25) and anti-carcinogenic effects in vitro (26)(27)(28)(29)(30) and in vivo (31,32). In PC, ITCs modulate epigenetic changes, induce the arrest of the cell cycle, activate apoptosis pathways and increase chemotherapeutic agent sensitivity; leading to the inhibition of cell proliferation, progression and invasionmetastasis (33).…”

Section: Introductionmentioning

confidence: 99%

“…2). 3-BI is known to have multiple effects, including anti-proliferative and anti-apoptotic effects, on colon (26,35), prostate, bone, cervical, liver, breast and neuroblastoma tumor cells (30). To date, there are no data on the effects of combination therapy of 3-BI and DOCE in PC.…”

Section: Introductionmentioning

confidence: 99%

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Effects of 3-butenyl isothiocyanate on phenotypically different prostate cancer cells

et al. 2018

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Isothiocyanates (ITCs) have gained increasing attention since they have been attributed the merits for the potential beneficial effects of cruciferous vegetable dietary consumption on cancer. The aim of the present study was to determine the cytotoxic effects of 3-butenyl ITC (3-BI) on prostate cancer (PC) cells under in vitro conditions. Two androgen-insensitive human PC cell lines, PC-3 and DU145, were assayed. Cells were cultured in the presence of increasing concentrations of 3-BI (5, 10, 30 and 50 µM) in the absence or presence of the chemotherapeutic drug docetaxel (DOCE) (1 and 2 nM). The cytotoxic effects of these compounds were analyzed using the trypan blue exclusion assay at 24, 48 and 72 h. Apoptosis and migration assays were also performed. The results showed that 3-BI induced a dose-dependent cytotoxic effect on PC-3 cells at 24, 48 and 72 h. These effects were significantly higher than those found with DOCE at 72 h of culture. Moreover, 3-BI also potentiated the effects of DOCE in a dose-dependent manner. Additionally, 3-BI showed inhibition of the migration of PC-3 cells. Nevertheless, 3-BI was not effective in the DU145 PC cell line. These results show a promising role for the 3-BI compound as a co-adjuvant agent in DOCE-based therapy in certain types of PC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of 3-butenyl isothiocyanate on phenotypically different prostate cancer cells

et al. 2018

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“…In fact, health-promoting values are from the hydrolysis products of glucosinolates rather than glucosinolates themselves. For instance, 3-butenyl isothiocyanate, a hydrolysis product of an aliphatic glucosinolate gluconapin, was reported to have antiproliferative activity against human prostate, lung, cervical, liver, and breast cancers, as well as human neuroblastoma and osteosarcoma cell lines [30]. Indole-3-carbinol, a hydrolysis product of glucobrassicin which was one of the major glucosinolates in the kale and collard cultivars used in this study, has been reported for its beneficial effect against obesity in mice [31,32].…”

Section: Glucosinolatesmentioning

confidence: 99%

Glucosinolates, Carotenoids, and Vitamins E and K Variation from Selected Kale and Collard Cultivars

Kim

Chiu

2017

Journal of Food Quality

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Glucosinolates, carotenoids, and fat-soluble vitamins E and K contents were analyzed from various kale and collard cultivars at mature stage. We found a significant difference in these phytonutrients among cultivars. Among kale cultivars, "Beira" and "Olympic Red" were the highest in the total glucosinolate and "Toscano" kale was the highest in total carotenoid content. "Scarlet" kale was highest in tocopherols. For collard, total glucosinolate was the highest in "Top Bunch" while carotenoids were the highest in "Green Glaze." An accession PI261597 was the highest in phylloquinone. In addition to the total content of each phytonutrient class, their composition differed among cultivars, indicating that each cultivar may have differential regulatory mechanisms for biosynthesis of these phytonutrients. Our result indicates that cultivar selection may play an important role in consumption of kale and collard with greater nutritional benefit. Therefore, the result of this study will provide a more thorough profile of essential and nonessential phytonutrients of kale and collard cultivars for consumers' choice and for future research on nutritional value of these crops.

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“…Pusa Jaikisan, which contains 3-butenyl isothiocyanate. However, in the latter study, an increase in caspase-3 activity was also observed in PC-3 cells [38].…”

Section: Effects Of Extracts From Specific Plant Families On Human Prmentioning

confidence: 53%

Anti-Prostate Cancer Activity of Plant-Derived Bioactive Compounds: a Review

Thomas-Charles

Fennell

2019

Curr Mol Bio Rep

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Purpose of Review Prostate cancer is one of the most common cancers in men and accounts for about 10% of all new cancer cases in the USA. Despite significant improvements in survival, it is estimated that deaths from prostate cancer in 2019 will exceed 30,000 individuals. Here, we review plant-derived bioactive compounds with the ability to modulate the growth of prostate cancer cells. These compounds represent potential therapeutic alternatives for the prevention and treatment of prostate cancer. Recent Findings Numerous plants produce phytochemicals that are important for their development and protection. Many of these compounds have inhibitory effects on the growth of cancer cells. Summary Cancers are a leading cause of death worldwide and treatments tend to be costly with many negative side effects. Identification of new potential chemo-therapeutic and chemo-protective compounds that have little or no negative effects on normal cells is therefore of great importance.

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3-Butenyl isothiocyanate: a hydrolytic product of glucosinolate as a potential cytotoxic agent against human cancer cell lines

Cited by 30 publications

References 26 publications

Effects of 3-butenyl isothiocyanate on phenotypically different prostate cancer cells

Effects of 3-butenyl isothiocyanate on phenotypically different prostate cancer cells

Glucosinolates, Carotenoids, and Vitamins E and K Variation from Selected Kale and Collard Cultivars

Anti-Prostate Cancer Activity of Plant-Derived Bioactive Compounds: a Review

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