3-D printed porous cellulose acetate tissue scaffolds for additive manufacturing

Huang, Hanxiao; Dean, Derrick

doi:10.1016/j.addma.2019.100927

Cited by 38 publications

(29 citation statements)

References 38 publications

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“…The cellulose acetate polymer is the most interesting of the cellulose derivatives for a wide variety of applications [ 15 , 16 ]. Due to its properties, including its relatively low cost, biocompatibility, biodegradation in human and animals [ 16 , 17 ], nonpoisonousness, mechanical strength, and dissolution in water, cellulose acetate has mainly been utilized in the field of TE [ 15 , 17 , 18 ]. It has also found use in bioapplications, drug delivery, antibacterial applications, and wound dressings [ 16 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of a Honeycomb-like Pattern with Cellulose Acetate and Silver Nanoparticles

et al. 2021

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This study involved the preparation and characterization of structures with a honeycomb-like pattern (HCP) formed using the phase separation method using a solution mixture of chloroform and methanol together with cellulose acetate. Fluorinated ethylene propylene modified by plasma treatment was used as a suitable substrate for the formation of the HCP structures. Further, we modified the HCP structures using silver sputtering (discontinuous Ag nanoparticles) or by adding Ag nanoparticles in PEG into the cellulose acetate solution. The material morphology was then determined using atomic force microscopy (AFM) and scanning electron microscopy (SEM), while the material surface chemistry was studied using energy dispersive spectroscopy (EDS) and wettability was analyzed with goniometry. The AFM and SEM results revealed that the surface morphology of pristine HCP with hexagonal pores changed after additional sample modification with Ag, both via the addition of nanoparticles and sputtering, accompanied with an increase in the roughness of the PEG-doped samples, which was caused by the high molecular weight of PEG and its gel-like structure. The highest amount (approx. 25 at %) of fluorine was detected using the EDS method on the sample with an HCP-like structure, while the lowest amount (0.08%) was measured on the PEG + Ag sample, which revealed the covering of the substrate with biopolymer (the greater fluorine extent means more of the fluorinated substrate is exposed). As expected, the thickness of the Ag layer on the HCP surface depended on the length of sputtering (either 150 s or 500 s). The sputtering times for Ag (150 s and 500 s) corresponded to layers with heights of about 8 nm (3.9 at % of Ag) and 22 nm (10.8 at % of Ag), respectively. In addition, we evaluated the antibacterial potential of the prepared substrate using two bacterial strains, one Gram-positive of S. epidermidis and one Gram-negative of E. coli. The most effective method for the construction of antibacterial surfaces was determined to be sputtering (150 s) of a silver nanolayer onto a HCP-like cellulose structure, which proved to have excellent antibacterial properties against both G+ and G− bacterial strains.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of a Honeycomb-like Pattern with Cellulose Acetate and Silver Nanoparticles

et al. 2021

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“…In biomedical and electronic application, the nanofiber structured silk/chitosan composite films prepared by facile solution casting technique exhibited improved hydrogen bonding interaction, mechanical performance, and biocompatibility with living cells. The biopolymer composite films can be potentially employed in biomedical and electronic display screens because of their strong nanofibril structure [147].…”

Section: Application Of Biopolymer Compositesmentioning

confidence: 99%

Biopolymer composites: a review

Aaliya

Sunooj

Lackner

2021

International Journal of Biobased Plastics

179

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In spite of the fact that a prodigious portion of petroleum covers multitudinous products in the commercial world, its nonbiodegradable characteristic is an unenviable factor. The utilization of biodegradable polymers or biopolymers is a prominent alternative to petroleum-based plastic products. Reinforcing natural fibers to biopolymer matrices significantly improves the properties of prepared plastic products. Such biopolymer composites have been developed by researchers to provide environmentally responsible materials and thereby reduce carbon footprint. Modification or functionalization of natural fibers is important to ameliorate the interfacial bonding with biopolymers, and to successfully obtain high-performance composite materials that can compete with conventional petrochemical-based polymer composite counterparts. Another widely accepted composite development technique is by combining different types of fibers into a single matrix to develop highly valued hybrid composites. The review focuses on the extraction, processing and characterization of bio-based materials; natural fibers and biopolymers, and their synergistic application and future scope as biopolymer composites in automotive and other growing sectors.

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“…Electrospun CA has also been used to immobilize bioactive substances as vitamins and enzymes, biosensors, bio-separation, and affinity purification membranes, while non-porous CA have been used for stent coatings or skin protection after burns or wounds. Interestingly, CA has also been proven as an effective material for tissue scaffold engineering, providing good mechanical stability, and ability to mimic the extracellular matrix for cell attachment, growth, and advanced formation of targeted tissues (e.g., bones and skin) [100]. Chainoglou et al has even demonstrated the possibilities of CA for heart valve tissue engineering, through a successful promotion of cardiac cell growth and proliferation [101].…”

Section: Cellulose Acetate (Ca)mentioning

confidence: 99%

“…The acetylation process reduces CA crystallinity and insolubility in water [100]. Industrially, CA is produced by the reaction of cellulose with an excess of acetic anhydride in the presence of sulfuric acid or perchloric acid as catalysts, in a two-step process of acetylation, followed by hydrolysis [105,106].…”

Section: Cellulose Acetate (Ca)mentioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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3-D printed porous cellulose acetate tissue scaffolds for additive manufacturing

Cited by 38 publications

References 38 publications

Antibacterial Properties of a Honeycomb-like Pattern with Cellulose Acetate and Silver Nanoparticles

Antibacterial Properties of a Honeycomb-like Pattern with Cellulose Acetate and Silver Nanoparticles

Biopolymer composites: a review

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

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