3-day treatment with azithromycin 1.5% eye drops versus 7-day treatment with tobramycin 0.3% for purulent bacterial conjunctivitis: multicentre, randomised and controlled trial in adults and children

Cochereau, Isabelle; Meddeb-Ouertani, Amel; Khairallah, Moncef; Amraoui, A.; Zaghloul, K.; Pop, Mihai; Delval, L.; Pouliquen, P; Tandon, Radhika; Garg, Prashant; Goldschmidt, Pablo; Bourcier, Tristan

doi:10.1136/bjo.2006.103556

Cited by 48 publications

(38 citation statements)

References 23 publications

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“…On day 9, the clinical cure rate of more than 80% was similar to those described in the overall population of this study 34 as well as those reported in the literature in children: 80% to 90%. 3,4,11 These levels even quite similar, were statistically different by bootstrap method (81.8% for tobramycin group versus 80% for azithromycin; P Ͻ 0.001).…”

Section: Discussionsupporting

confidence: 90%

Efficacy and Safety of Azithromycin 1.5% Eye Drops for Purulent Bacterial Conjunctivitis in Pediatric Patients

Bremond-Gignac¹,

Mariani‐Kurkdjian²,

Béresniak³

et al. 2010

Pediatric Infectious Disease Journal

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Section: Discussionsupporting

confidence: 90%

Efficacy and Safety of Azithromycin 1.5% Eye Drops for Purulent Bacterial Conjunctivitis in Pediatric Patients

Bremond-Gignac¹,

Mariani‐Kurkdjian²,

Béresniak³

et al. 2010

Pediatric Infectious Disease Journal

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“…It binds reversibly to the 50S subunit of the bacterial ribosome and inhibits RNAdependent protein synthe (13) . Azithromycin was studied in bacterial conjunctivitis and proved to be both effective and safe with good patient tolerance (14,15) . The purpose of the present study is to determine the efficacy of topical azithromycin 1.5% ophthalmic solution combined with eye lid hygiene in the treatment of patients with moderate to severe anterior and/or posterior blepharitis and to compare two different modalities of administration: a threeday regimen versus a prolonged onemonth regimen.…”

Section: Introductionmentioning

confidence: 99%

Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis

Fadlallah¹,

Rami²,

Fahd³

et al. 2012

Arq. Bras. Oftalmol.

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Purpose: To assess the efficacy of topical 1.5% azithromycin in the treatment of mo derate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. Methods: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followedup for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eyefriendly soap twice daily. Results: Patients in both groups tolerated the treatment with minimal irritation. A signi ficant improvement in signs and symptoms was noted at the one week fol lowup visit. Group II showed a more pronounced and longerlasting improvement that persisted after three months of followup. Conclusion: Topical 1.5% azithromycin ophthalmic solution is an effective treat ment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the threeday protocol with no significant relapse until three months of followup.

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“…The problem arose in a few cases in the daily dosing schedule of Tobramycin 0.3%, Ofloxacin 0.3% and Gatifloxacin 0.3% when used in the postoperative setting. Two cases out of twelve who were administered Tobramycin and one out of six administered Ofloxacin were using the drug twice a day instead of the standard regimen of six hourly administration 13 . One person was incorrectly administered Gatifloxacin three times a day against the standard regimen of six hourly dosing 14 .…”

Section: Discussionmentioning

confidence: 99%

Role of Antimicrobials in Intra Ocular Lens (Iol) Implantation

Banderao¹,

Binjawadgi²,

Dass³

2013

jemds

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-CONTEXT: Pharmacotherapy which means use of drugs for prevention and treatment of diseases is a major branch of therapeutics. Cataract, particularly in the age group of 40-75 years is fairly common.Many potent drugs like Glucocorticoids, Antimicrobials etc. are used in the management of cataract. Antimicrobials use has led to a big concern amongst clinicians as many consider it to be unnecessary, inappropriate and downright dangerous.Recently increased attention has been diverted to rational prescribing and drug utilisation studies play a major role in this regard. These studies not only detect flaws in the therapy, but also help to find out solution to rectify the same.Anti-microbials are prescribed for almost all cases posted for Intra Ocular Lens Implantation Surgery. Hence the present prospective observational study was undertaken with respect to the use of anti-microbials (both prophylactic and post-operative) in Ophthalmology practice. Page 4853 RESULTS AND CONCLUSION: Our study found that Moxifloxacin is the most frequently prescribed anti-microbial pre-operatively for IOL implantation. Also, Moxifloxacin is the most frequently prescribed anti-microbial post-operatively for IOL implantation.Overall Moxifloxacin is currently the most frequently prescribed anti-microbial for both pre and post-operative use in IOL implantation surgery.

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3-day treatment with azithromycin 1.5% eye drops versus 7-day treatment with tobramycin 0.3% for purulent bacterial conjunctivitis: multicentre, randomised and controlled trial in adults and children

Cited by 48 publications

References 23 publications

Efficacy and Safety of Azithromycin 1.5% Eye Drops for Purulent Bacterial Conjunctivitis in Pediatric Patients

Efficacy and Safety of Azithromycin 1.5% Eye Drops for Purulent Bacterial Conjunctivitis in Pediatric Patients

Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis

Role of Antimicrobials in Intra Ocular Lens (Iol) Implantation

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