3-Hydroxy-3′,4′-dimethoxyflavone suppresses Bcl-w-induced invasive potentials and stemness in glioblastoma multiforme

Bae, In Hwa; Lee, Woo Sang; Yun, Dong Ho; Han, Young‐Hoon; Lee, Jae‐Seon

doi:10.1016/j.bbrc.2014.06.038

Cited by 7 publications

(9 citation statements)

References 17 publications

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“…Recent reports have emerged the anticancer potential of flavonoids by inhibiting cancer stem cells (Bae et al ., ; Chakrabarti and Ray, ; Feng et al ., ; Sak and Everaus, ; Zhang et al ., ). Apigenin suppressed the self‐renewal capacity of cervical cancer stem‐like cells derived from HeLa cell line as well as ovarian cancer SKOV3‐derived cancer stem‐like cells through the downregulation of expression of casein kinase 2α (CK2α), which has been implicated in the activation of Hedgehog and Notch pathways and the maintenance of cancer stem cell properties (Liu et al ., ; Tang et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…They serve a variety of biological activities such as antioxidant, antiinflammatory, antiviral, and anticancer actions (Cazarolli et al ., ). Recently, several studies have identified the therapeutic potential of flavonoids to eliminate GSCs (Bae et al ., ; Chakrabarti and Ray, ; Feng et al ., ; Zhang et al ., ). However, the molecular mechanisms of this effect by flavonoids are still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Apigenin Inhibits Cancer Stem Cell‐Like Phenotypes in Human Glioblastoma Cells via Suppression of c‐Met Signaling

Kim

Jung

Lee

et al. 2016

Phytotherapy Research

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Glioblastoma (GBM) is a highly malignant human brain tumor with limited treatment choices. The extremely aggressive characteristics of GBM result from GBM stem cells (GSCs), a subpopulation in tumor having self-renewal potential and resistance to chemotherapy and radiotherapy. Therefore, eliminating GSCs is an effective strategy to treat this fatal disease. In this study, we investigated the therapeutic effects of dietary flavonoids, including apigenin, quercetin, and naringenin, against cancer stem cell-like phenotypes of human GBM cell lines U87MG and U373MG. Among flavonoids studied, apigenin and quercetin significantly suppressed not only the self-renewal capacity such as cell growth and clonogenicity, but also the invasiveness of GBM stem-like cells. Notably, apigenin blocked the phosphorylation of c-Met and its downstream effectors, transducer and activator of transcription 3, AKT (Protein kinase B), and mitogen-activated protein kinase in the GSCs, thereby reducing the expression levels of GSC markers such as CD133, Nanog, and Sox2. These results suggest that the GSC inhibition effect of apigenin may be caused by downregulation of c-Met signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Apigenin Inhibits Cancer Stem Cell‐Like Phenotypes in Human Glioblastoma Cells via Suppression of c‐Met Signaling

Kim

Jung

Lee

et al. 2016

Phytotherapy Research

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“…Increased BCL-w level was accompanied with upregulation of platelet-derived growth factor alpha (PDGFα) 103 . BCL-w overexpression also promoted formation of neurospheres 105 . BCL-w was required for tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-dependent protection of glioblastoma cells against TRAIL and camptothecin 106 .…”

Section: Contribution Of Bcl-w To Survival Of Cancer Cells and Their mentioning

confidence: 91%

“…Mechanistically, BCL-w increases the level of mitochondriaderived reactive oxygen species (ROS), which is followed by SRC-mediated phosphorylation of EGFR 145 , and the activation of PI3K/AKT/Sp1 signaling pathway to increase MMP2 expression in GBM and gastric cancer cells 18,104,146 . BCL-w promotes activation of MMP-2 and FAK via PI3K/AKT/β-catenin signaling pathway in GBM cells 105,142 , while BCL-w-induced nuclear accumulation of β-catenin contributes to the upregulation of vimentin ( Fig. 3) 141,142 .…”

Section: Role Of Bcl-w In Migratory and Invasive Potentials Of Cancermentioning

confidence: 99%

BCL-w: apoptotic and non-apoptotic role in health and disease

Hartman

Czyż

2020

Cell Death Dis

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The BCL-2 family of proteins integrates signals that trigger either cell survival or apoptosis. The balance between prosurvival and pro-apoptotic proteins is important for tissue development and homeostasis, while impaired apoptosis contributes to several pathologies and can be a barrier against effective treatment. BCL-w is an anti-apoptotic protein that shares a sequence similarity with BCL-X L , and exhibits a high conformational flexibility. BCL-w level is controlled by a number of signaling pathways, and the repertoire of transcriptional regulators largely depends on the cellular and developmental context. As only a few disease-relevant genetic alterations of BCL2L2 have been identified, increased levels of BCL-w might be a consequence of abnormal activation of signaling cascades involved in the regulation of BCL-w expression. In addition, BCL-w transcript is a target of a plethora of miRNAs. Besides its originally recognized pro-survival function during spermatogenesis, BCL-w has been envisaged in different types of normal and diseased cells as an anti-apoptotic protein. BCL-w contributes to survival of senescent and drug-resistant cells. Its non-apoptotic role in the promotion of cell migration and invasion has also been elucidated. Growing evidence indicates that a high BCL-w level can be therapeutically relevant in neurodegenerative disorders, neuron dysfunctions and after small intestinal resection, whereas BCL-w inhibition can be beneficial for cancer patients. Although several drugs and natural compounds can bi-directionally affect BCL-w level, agents that selectively target BCL-w are not yet available. This review discusses current knowledge on the role of BCL-w in health, non-cancerous diseases and cancer.

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“…Curcumin is a hydrophobic polyphenol mainly present in the rhizome of turmeric and possess antioxidant, antiinflammatory, anti-microbial, anti-carcinogenic, hepatoprotective, nephroprotective and cardioprotective activities [30] . 3-Hydroxy-3,4dimethoxy flavones is a natural anticancer drug and its cytotoxic and wound healing properties have been reported [31] . Thus, presence of various flavonoids in the aqueous extract might attribute to the various medicinal properties including antioxidant activity of M. lutea.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity and Phytochemical Composition of Aqueous Extract of Markhamia lutea (Benth) K. Schum. Leaves

Brindha¹,

Ragamanvitha²,

Rajendran³

et al. 2017

TJNPR

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3-Hydroxy-3′,4′-dimethoxyflavone suppresses Bcl-w-induced invasive potentials and stemness in glioblastoma multiforme

Cited by 7 publications

References 17 publications

Apigenin Inhibits Cancer Stem Cell‐Like Phenotypes in Human Glioblastoma Cells via Suppression of c‐Met Signaling

Apigenin Inhibits Cancer Stem Cell‐Like Phenotypes in Human Glioblastoma Cells via Suppression of c‐Met Signaling

BCL-w: apoptotic and non-apoptotic role in health and disease

Antioxidant Activity and Phytochemical Composition of Aqueous Extract of Markhamia lutea (Benth) K. Schum. Leaves

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