3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera

Koo, Minseon; Kim, S.H.; Lee, N.; Yoo, Miyoun; Ryu, Shi Young; Kwon, Dae-Young; Kim, Y.S.

doi:10.1016/j.fitote.2007.11.005

Cited by 20 publications

(13 citation statements)

References 6 publications

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“…37 Another possible explanation for the French Paradox and the effect of polyphenols may be explained by vitisin A and vitisin B, which showed a remarkable inhibitory activity against 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMGCoA) reductase. 38 HMG-CoA reductase is an NADPH-dependent enzyme and the rate-limiting step of the metabolic pathway that produces cholesterol and other isoprenoids, namely, the mevalonate pathway, and is a key target of the widely available statin cholesterol-lowering drugs. This may explain in part some aspect of the French Paradox as well.…”

Section: The French Paradox and Lipid Metabolismmentioning

confidence: 99%

The Role of Polyphenolic Antioxidants in Health, Disease, and Aging

Obrenovich

Nair

Beyaz

et al. 2010

Rejuvenation Research

119

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Polyphenolic antioxidants from dietary sources are frequently a topic of interest due to widespread scientific agreement that they may help lower the incidence of certain cancers, cardiovascular and neurodegenerative diseases, and DNA damage and even may have antiaging properties. On the other hand, questions still remain as to whether some antioxidants could be potentially harmful to health, because an increase in glycation-mediated protein damage (carbonyl stress) has been reported in some cases. Nevertheless, the quest for healthy aging has led to the extensive use of phytochemically derived antioxidants to disrupt age-associated deterioration in physiological function and to prevent many age-related diseases. Although a diet rich in the polyphenolic forms of antioxidants does seem to offer hope in delaying the onset of age-related disorders, it is still too early to define their exact clinical benefit for treating age-related disease. This review critically examines polyphenolic antioxidants, such as flavonoids, curcumene, and resveratrol in health, disease, and aging with the hope that a better understanding of the many mechanisms involved with these diverse compounds may lead to better health and novel treatment approaches for age-related diseases.

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Section: The French Paradox and Lipid Metabolismmentioning

confidence: 99%

The Role of Polyphenolic Antioxidants in Health, Disease, and Aging

Obrenovich

Nair

Beyaz

et al. 2010

Rejuvenation Research

119

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“…In rats, resveratrol administration prevented the decrease in vascular NO induced by inflammatory mediators, and it decreased the expression of TNF‐α 64 . In addition, previous studies have shown that Vitisin A, a resveratrol tetramer purified from the skin of grape trees, has anti‐inflammatory, 65, 66 antiadipogenic, 67 and anticholestrolemic activities 68 . Vitisin A reduces the expression of LPS‐stimulated proinflammatory markers in macrophages and decreases adipocyte differentiation by inhibiting PPARγ activation.…”

Section: Targeting Inflammation By Nutraceuticals In Obesity and Insumentioning

confidence: 99%

Inflammation‐mediated obesity and insulin resistance as targets for nutraceuticals

Kim

Lee

Kown

2011

Annals of the New York Academy of Sciences

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Obesity-induced inflammation plays an important role in the development of insulin resistance, type 2 diabetes (T2D), and metabolic dysfunctions. Chronic activation of proinflammatory pathways within insulin target cells can lead to obesity-related insulin resistance. The inflammatory mediators consist of immune cells, cytokines, adipokines, and inflammatory signaling molecules. Targeting obesity-associated inflammation has been shown to protect experimental animals and human subjects from obesity-induced insulin resistance. Modulation of the inflammatory responses associated with obesity may help prevent or improve obesity-induced metabolic dysfunctions. In this review, we introduce the beneficial effects of nutraceuticals for targeting inflammation in the treatment of obesity-induced insulin resistance and metabolic dysfunctions.

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“…However, the genus of Vitis contains a great diversity of oligostilbenes which are biogenetically synthesized by oxidative coupling of resveratrol or (+)--viniferin [3]. Vitisin A, heyneanol A, vitisin B, and other tetrameric stilbenes exhibit many potent biological activities such as protective effects against ␤-amyloid-induced neurotoxicity [4], 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibition [5], influenza A virus-induced airway inflammatory response inhibition [6], DNA topoisomerase II inhibition [7], and antifungal activities [8].…”

Section: Introductionmentioning

confidence: 99%