3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and abating DNA damage

Owumi, Solomon E.; Najophe, Eseroghene S.; Otunla, Moses T.

doi:10.1007/s11356-022-21075-3

Cited by 16 publications

(3 citation statements)

References 72 publications

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Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

“…Pesticide-induced hepatorenal toxicity in rats was found to be rescued after 14 days of treatment with IPA [ 94 ]. IPA was able to significantly restore hepatorenal activity, DNA damage, apoptotic response, antioxidant/pro-oxidant, and pro-inflammatory/anti-inflammatory balance along with hepatorenal histological changes [ 94 , 95 ]. Serum hepatic transaminases were also found to be reduced in the IPA-treated rats in a dose-dependent manner, pointing towards IPA’s potential as a hepatoprotective molecule [ 94 ].…”

Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

“…IPA was able to significantly restore hepatorenal activity, DNA damage, apoptotic response, antioxidant/pro-oxidant, and pro-inflammatory/anti-inflammatory balance along with hepatorenal histological changes [ 94 , 95 ]. Serum hepatic transaminases were also found to be reduced in the IPA-treated rats in a dose-dependent manner, pointing towards IPA’s potential as a hepatoprotective molecule [ 94 ]. Ren et al performed serum and liver metabolomics of dimethylnitrosamine-induced spontaneous hepatocellular carcinoma mice and reported serum IPA levels to be the most strongly associated with the progression of hepatocellular carcinoma [ 96 ].…”

Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

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Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

et al. 2022

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An intricate relationship between gut microbiota, diet, and the human body has recently been extensively investigated. Gut microbiota and gut-derived metabolites, especially, tryptophan derivatives, modulate metabolic and immune functions in health and disease. One of the tryptophan derivatives, indolepropionic acid (IPA), is increasingly being studied as a marker for the onset and development of metabolic disorders, including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). The IPA levels heavily depend on the diet, particularly dietary fiber, and show huge variations among individuals. We suggest that these variations could partially be explained using genetic variants known to be associated with specific diseases such as T2D. In this narrative review, we elaborate on the beneficial effects of IPA in the mitigation of T2D and NAFLD, and further study the putative interactions between IPA and well-known genetic variants (TCF7L2, FTO, and PPARG), known to be associated with the risk of T2D. We have investigated the long-term preventive value of IPA in the development of T2D in the Finnish prediabetic population and the correlation of IPA with phytosterols in obese individuals from an ongoing Kuopio obesity surgery study. The diversity in IPA-linked mechanisms affecting glucose metabolism and liver fibrosis makes it a unique small metabolite and a promising candidate for the reversal or management of metabolic disorders, mainly T2D and NAFLD.

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Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Section: Indolepropionic Acid and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

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Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

et al. 2022

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3-Indolepropionic acid mitigates sub-acute toxicity in the cardiomyocytes of epirubicin-treated female rats

Owumi

Arunsi

Otunla

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats

Küçükler,

Caglayan,

Özdemir

et al. 2023

Metab Brain Dis

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3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and abating DNA damage

Cited by 16 publications

References 72 publications

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

3-Indolepropionic acid mitigates sub-acute toxicity in the cardiomyocytes of epirubicin-treated female rats

Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats

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