The security of message information has drawn more attention nowadays, so; cryptography has been used extensively. This research aims to generate secured cipher keys from retina information to increase the level of security. The proposed technique utilizes cryptography based on retina information. The main contribution is the original procedure used to generate three types of keys in one system from the retina vessel's end position and improve the technique of three systems, each with one key. The distances between the center of the diagonals of the retina image and the retina vessel's end (diagonal center-end (DCE)) represent the first key. The distances between the center of the radius of the retina and the retina vessel's end (radius center-end (RCE)) represent the second key. While the diagonal-radius center and the retina vessel's end (diagonal-radius center-end (DRCE)) represent the third key. The results illustrate the process's validity and applicability. Also, improve the time required to decrypt the cipher-text by a brute force attack (BFA) from (4.358e+139) year in the compared technique to (1.3074e+140) year for retina3. The BFA time will increase with increasing the number of retina vessels, as in retina1, 2, and 3, which have 24, 53, and 103 retina vessels.