3-Methoxy-catalposide inhibits inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages

Ryu, Hyung Won; Lee, Su Ui; Lee, Seoghyun; Song, Hyuk‐Hwan; Son, Tae Hyun; Kim, Yeah-Un; Yuk, Heung Joo; Ro, Hyunju; Lee, Chong-Kil; Hong, Sung-Tae; Oh, Sei‐Ryang

doi:10.1016/j.cyto.2016.12.006

Cited by 42 publications

(23 citation statements)

References 38 publications

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“…During the process, various immune cells, such as monocytes, neutrophils, and activated T cells, infiltrate from the blood into the gingival sulcus. These activated cells can produce and release inflammatory mediators, such as ILs, tumor necrosis factors (TNFs), and so on (Ryu et al, 2016 ; Zhou et al, 2016 ). These cytokines, in turn, augment the chemotactic signals that are generated during inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects

et al. 2018

Front. Cell. Infect. Microbiol.

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Psoralen and angelicin are two effective compounds isolated from psoraleae, a traditional Chinese medicine. They have a wide range of applications for bone disease treatment and immune modulation. In this study, we explored their new applications for the treatment of periodontal diseases. This study aimed to investigate the effects of psoralen and angelicin on Porphyromonas gingivalis growth and P. gingivalis-derived lipopolysaccharide (Pg-LPS)-induced inflammation, and further to evaluate their effects on osteogenesis. Finally, the effects of angelicin on a mouse model of periodontitis were also investigated. The results showed that psoralen and angelicin had beneficial dose-dependent effects regarding the inhibition of planktonic P. gingivalis and biofilms of P. gingivalis. There were no significant differences in the viability of monocyte-like THP-1 cells and human periodontal ligament cells (hPDLCs) treated with either psoralen or angelicin compared to the untreated control cells. Psoralen and angelicin also markedly decreased the mRNA expression and release of inflammatory cytokines (interleukin [IL]-1β and IL-8) by THP-1 cells in a dose-dependent manner. They significantly enhanced the alkaline phosphatase (ALP) activity of hPDLCs and up-regulated the expression of osteogenic proteins (runt-related transcription factor 2 [RUNX2], distal-less homeobox 5 [DLX5], and osteopontin [OPN]). Angelicin significantly attenuated alveolar bone loss and inflammation response in the mice with periodontitis. In conclusion, our data demonstrated that psoralen and angelicin could inhibit the growth of planktonic P. gingivalis and P. gingivalis biofilm. It is also the first report on the anti-inflammatory effect of psoralen and angelicin against Pg-LPS. They also had an osteogenesis-potentiating effect on hPDLCs. The in vivo study also indicated the effect of angelicin regarding protection against periodontitis. Our study highlighted the potential ability of psoralen and angelicin to act as novel natural agents to prevent and treat periodontitis.

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Section: Discussionmentioning

confidence: 99%

New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects

et al. 2018

Front. Cell. Infect. Microbiol.

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“…Inflammation is characterized by well-coordinated events in response to harmful stimuli, such as injury, infection, and irritants [ 14 , 15 ]. However, uncontrolled and chronic inflammation can lead to several diseases, such as autoimmune diseases, rheumatoid arthritis, asthma, and inflammatory bowel disease [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling

Kim¹,

Kim²,

Choi³

et al. 2018

Nutrients

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The fruit of Stauntonia hexaphylla is commonly used as a traditional anthelmintic in Korea, Japan, and China. However, its anti-inflammatory activity and the underlying mechanisms have not been studied systematically. In the present study, we examined the anti-inflammatory activities of an aqueous extract of S. hexaphylla fruit (SHF) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The SHF extract contained anti-inflammatory compounds, such as neochlorogenic acid, chlorogenic acid, and cryptochlorogenic acid. The extract inhibited protein levels of inducible nitric oxide synthase and the activity of cyclooxygenase enzyme, with concomitant reductions in the production of nitric oxide and prostaglandin E2 in LPS-activated RAW 264.7 cells. Additionally, the SHF extract reduced the production of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. The SHF extract attenuated LPS-induced nuclear factor-κB (NF-κB) activation by decreasing the phosphorylation of its inhibitor, IκBα. Furthermore, the SHF extract showed a significant anti-inflammatory effect in vivo by reducing the volume of carrageenan-induced paw edema in rats. Our results suggest that the SHF extract exerts potential anti-inflammatory properties against LPS-activated RAW 254.7 cells, and in an animal model of inflammation.

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“… [ 24 ] 3-Methoxy-catalposide Pseudolysimachion rotundum Iridoid glycoside Inhibitory effect on lipopolysaccharide stimulated RAW264.7 macrophages. [ 73 ] 7-Glucuronic acid-5,6-dihydroxyflavone Scutellaria baicalensis Flavonoid Inhibitor of phosphodiesterase 4A and 4B. Downregulates the expression of TNF-α.…”

Section: Plant-based Biomolecules With Antiviral Activitiesmentioning

confidence: 99%

Genomics approaches to synthesize plant-based biomolecules for therapeutic applications to combat SARS-CoV-2

et al. 2020

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COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is devastative to the humankind for which neither vaccines nor precise therapeutic molecules for treatment are identified. The search for new drugs and repurposing of existing drugs are being performed; however, at the same time, research on plants to identify novel therapeutic compounds or testing the existing ones is progressing at a slower phase. In this context, genomics and biotechnology offer various tools and strategies to manipulate plants for producing those complex biopharmaceutical products. This review enumerates the scope for research on plant-based molecules for their potential application in treating SARS-CoV-2 infection. Strategies to edit gene and genome, overexpression and silencing approaches, and molecular breeding for producing target biomolecules in the plant system are discussed in detail. Altogether, the present review provides a roadmap for expediting research on using plants as a novel source of active biomolecules having therapeutic applications.

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3-Methoxy-catalposide inhibits inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages

Cited by 42 publications

References 38 publications

New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects

New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects

Anti-Inflammatory Effects of a Stauntonia hexaphylla Fruit Extract in Lipopolysaccharide-Activated RAW-264.7 Macrophages and Rats by Carrageenan-Induced Hind Paw Swelling

Genomics approaches to synthesize plant-based biomolecules for therapeutic applications to combat SARS-CoV-2

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