3: Sweetening agents in food, drinks and medicine: Cariogenic potential and adverse effects

Db, Drucker

doi:10.3109/09637487909143361

Cited by 11 publications

(5 citation statements)

References 53 publications

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“…30 5. rebaudiana (cultivation, constituents, commercialization prospects) and stevioside (chemistry, biological effects, safety, utilization) have been the subjects of many review articles over the last decades, including those by Thomas (1937), 177 , 17 ' Kazuyama (1979), 1 " Fujita and Edahiro (1979), 175 Tanaka (1982), 173 Sakaguchi and Kan (1982), 162 and . 30 …”

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confidence: 99%

Sweetening agents of plant origin*

Kinghora

Soejarto

Inglett

1986

Critical Reviews in Plant Sciences

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confidence: 99%

Sweetening agents of plant origin*

Kinghora

Soejarto

Inglett

1986

Critical Reviews in Plant Sciences

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“…The first three groups allow limited acid production by oral bacteria and have been proved to be essentially non-cariogenic in rats. However, sugar alcohols are absorbed only slowly through the intestinal lumen, which is probably the cause of osmotic diarrhea in both humans and rats (1,2). Since dental caries is a disease prevalent in children and adolescents who need sufficient energy for their growth and development, sucrose substitutes should serve as energy resources without causing any side-effects such as diarrhea.…”

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confidence: 99%

The Caries Inhibitory Effects of GOS‐Sugar in vitro and in Rat Experiments

Ooshima

Fujiwara²,

Takei³

et al. 1988

Microbiology and Immunology

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The caries inhibitory activity of GOS-sugar (panose-and maltose-rich sugar mixture) was examined and compared with that of sucrose, maltose, or glucose in in vitro and in vivo experiments. Streptococcus mutans MT8148R (serotype c) and Streptococcus sobrinus 6715 (g) did ferment GOS-sugar and produce acid in a similar way as with maltose and glucose. However, GOS-sugar could not be a substrate for the glucosyltransferases (GTases) of these mutans streptococci to synthesize the water-insoluble glucan. Also, it significantly inhibited not only the synthesis of waterinsoluble glucan from sucrose by the crude GTases but also the sucrose-dependent adherence of these cells to a glass surface. In particular, adherence of growing cells of 6715 was markedly inhibited by the presence of GOS-sugar. GOS-sugar was found to induce significant but minimal dental caries in SPF rats infected with either MT8148R or 6715. Furthermore, the replacement of half of the dietary sucrose content with GOS-sugar resulted in a significant reduction of caries development in rats infected with strain 6715.

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“…Frequent and/or excessive sugar (especially sucrose) consumption has been described to play a central role in caries causation, and S. mutans appeared to play a key role in metabolizing sucrose to produce lactic acid, which can demineralize enamel [ 16 ]. The cariogenic nature of sucrose has led to an intensive search for alternative compounds possessing sweetness without cariogenicity [ 17 ]. Sucrose substitutes that are not metabolized by plaque-forming bacteria, particularly S. mutans , have been proposed as a promising approach to caries prevention [ 18 ].…”

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Cariogenicity features of Streptococcus mutans in presence of rubusoside

2016

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BackgroundOne promising way of reducing caries is by using sucrose substitutes in food. rubusoside is a prototype sweet substance isolated from the leaves of the plant Rubrus suavissimus S. Lee. (Rosaceae), and is rated sweeter than sucrose. The purpose of this study was to investigate the effects of rubusoside on Streptococcus mutans growth, acidogenicity, and adherence to glass in vitro.MethodsThe effects of rubusoside on the growth and glass surface adhering of Streptococcus mutans were investigated by measuring the optical density of the culture at 540 nm with a spectrophotometer. Rubusoside influence on Streptococcus mutans acidogenicity was determined by measuring the pH of the culture. Sucrose, glucose, maltose, fructose and xylitol were designed to compare with rubusoside.ResultsS. mutans growth in the rubusoside-treated group was significantly lower than that in the sucrose, glucose, maltose and fructose groups (p < 0.05) except for xylitol group (p > 0.05). Sucrose-treated S. mutans exhibited the highest adherence to glass, and rubusoside-treated S. mutans exhibited the lowest. S. mutans adherence to a glass surface and acidogenicity with sucrose were significantly reduced by rubusoside.ConclusionsRubusoside may have some potential as a non-cariogenic, non-caloric sweetener.

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3: Sweetening agents in food, drinks and medicine: Cariogenic potential and adverse effects

Cited by 11 publications

References 53 publications

Sweetening agents of plant origin*

Sweetening agents of plant origin*

The Caries Inhibitory Effects of GOS‐Sugar in vitro and in Rat Experiments

Cariogenicity features of Streptococcus mutans in presence of rubusoside

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