-308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and metabolic syndrome susceptibility: a meta-analysis

Wang, Dong; He, Liqun; Zhang, Xiaotian

doi:10.1038/s41598-021-83321-x

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…For identifying the risk variants that cause the disease of interest, the "candidate gene studies approach" has been at the forefront in uncovering the correlation between genetic variants with complex diseases [22]. Multiple meta-analyses and other researchers have found a relationship between TNF-α 308GandA polymorphism with variations in susceptibility to several diseases between diferent people and, on a wider scale, across diferent populations [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Role of TNF-α in the Pathogenesis of Migraine

Sudershan,

Sharma

et al. 2024

Pain Research and Management

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Background. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range of inflammatory reactions. Aim. In this review, we aimed to provide a culminating and comprehending glimpse into the TNF-α in association with the migraine. Method. A systematic literature survey method with a mixture of keywords was utilized to grasp the different elements that represent the association between TNF-α and migraine. Discussion. Highlighted the probable involvement of the TNF-α with migraine, the complexity of the matter such as activation of NF-KB signaling cascade, autoactivation, sensitization, and increased likelihood of transition cannot be neglected. Being TNF-α as a core node, it becomes the factor for linking diseases such as chronic inflammatory disorders, including COVID-19, and also interaction with other genes to develop severe conditions. Conclusion. To this end, TNF-α plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy.

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Section: Introductionmentioning

confidence: 99%

Role of TNF-α in the Pathogenesis of Migraine

Sudershan,

Sharma

et al. 2024

Pain Research and Management

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“…A systematic review suggested that TNF-α could be an early biomarker to detect MetS [ 24 ]. Some studies have demonstrated that TNF-α gene polymorphisms were associated with the susceptibility of MetS, but the results were inconsistent in different ethnic groups [ 25 ]. Making an effort to elucidate the interactions of TNF-α genetic variants and environment was considered as a potential method to improve MetS [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Metabolic Syndrome and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms

Chen

Kung²,

Sun

et al. 2021

Toxics

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With the escalating global prevalence of metabolic syndrome (MetS), it is crucial to detect the high-risk population early and to prevent chronic diseases. Exposure to various metals has been indicated to promote MetS, but the findings were controversial, and the effect of genetic modification was not considered. Epidermal growth factor receptor (EGFR) was proposed to be involved in the pathway of metabolic disorders, and tumor necrotic factor-α (TNF-α) was regarded as an early inflammatory biomarker for MetS. This research aimed to analyze the impact of EGFR and TNF-α gene polymorphisms on the prevalence of MetS under environmental or occupational exposure to metals. We gathered data from 376 metal industrial workers and 639 non-metal workers, including physical parameters, biochemical data, and plasma concentrations of six metals. According to the genomic database of Taiwan Biobank, 23 single nucleotide polymorphisms (SNPs) on EGFR gene and 6 SNPs on TNF-α gene were incorporated in our research. We applied multivariable logistic regression to analyze the probability of MetS with various SNPs and metals. Our study revealed some susceptible and protective EGFR and TNF-α genotypes under excessive exposure to cobalt, zinc, selenium, and lead. Thus, we remind the high-risk population of taking measures to prevent MetS.

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Enlightening the association between TNF-α -308 G > A and migraine: a meta-analysis with meta-regression and trial sequential analysis

Sudershan

Younis

et al. 2023

BMC Neurol

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Background Migraine is a complex neurological disorder that is characterized by a "lower threshold of neuronal hyperexcitability" with distinctive periodicity and complex vascular dysfunction. Genetic factors have impacted incredibly on the susceptibility of migraine and one such example is the TNF-α 308G > A. Aim Therefore, we aim to provide a glimpse of the association of the TNF-α 308G > A risk on the susceptibility of migraine. Method The pooled odds ratio with the associated 95% of confidence interval were calculated using different genetic models. Heterogeneity was accessed by using Cochran's Q Test and I2 statistics and Begg's and Egger's tests were used for finding the publication bias, tests were two-sided, and a p-value of < 0.05 was considered statistically significant. The Trial Sequential Analysis with Meta-regression Analysis were also utilized to find out the sample size requirement for meta-analysis to avoid type I error and source of heterogeneity respectively. Result A total of 13 studies with cases: 7193 and controls: 23,091 were included and after using different genetic models, no overall association with migraine and its clinical subtype migraine with aura was observed (Allele model “OR: 1.28, 95% C.I. [0.96–1.69] and OR: 0.99,95% C.I. [0.69–1.42]) respectively. Interestingly, after sub-grouping using the “ethnicity criteria” in the migraine group, it was observed that the allelic genetic model and the dominant model were found to be significantly associated with the Asian ethnic group (OR: 1.79, 95% C.I. [1.13–2.84], and OR: 1.85, 95% C.I. [1.0927; 3.1580]. Conclusion In conclusion, the present meta-analysis has provided evidence that 308G > A increases the risk of migraine only in the Asian population.

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-308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and metabolic syndrome susceptibility: a meta-analysis

Cited by 5 publications

References 39 publications

Role of TNF-α in the Pathogenesis of Migraine

Role of TNF-α in the Pathogenesis of Migraine

The Relationship between Metabolic Syndrome and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms

Enlightening the association between TNF-α -308 G > A and migraine: a meta-analysis with meta-regression and trial sequential analysis

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