310 Maternal Exposure to Nitrogen Oxides and Complications of Pregnancy

Tabacova, Sonia; Little, Ruth E.; Balabaeva, Liudmila

doi:10.1097/00001648-199503000-00334

Cited by 15 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite limited data, several human data suggest an association of phthalate exposure and adverse reproductive health outcomes (1,(12)(13)(14). Long-term occupational exposure to high levels of phthalates is associated with decreased pregnancy rates and higher rates of miscarriage in female factory workers (12).…”

mentioning

confidence: 99%

Increased plasma levels of phthalate esters in women with advanced-stage endometriosis: a prospective case-control study

Kim

Chun

Jang

et al. 2011

Fertility and Sterility

100

View full text Add to dashboard Cite

mentioning

confidence: 99%

Increased plasma levels of phthalate esters in women with advanced-stage endometriosis: a prospective case-control study

Kim

Chun

Jang

et al. 2011

Fertility and Sterility

100

View full text Add to dashboard Cite

“…For example, chronic occupational exposure to high levels of phthalates is associated with decreased rates of pregnancy and higher rates of miscarriage in female factory workers (Aldyreva et al 1975). Higher urinary phthalate levels correlated with pregnancy complications such as anemia, toxemia, and preeclampsia in women living near a plastics manufacturer (Tabacova 1999). Although occupational exposure is limited to a select population, women have exposures to phthalates in beauty and consumer products on a daily basis.…”

mentioning

confidence: 99%

Mechanisms of phthalate ester toxicity in the female reproductive system.

Lovekamp-Swan

Davis

2003

Environ Health Perspect

582

288

View full text Add to dashboard Cite

Phthalates are high-production-volume synthetic chemicals with ubiquitous human exposures because of their use in plastics and other common consumer products. Recent epidemiologic evidence suggests that women have a unique exposure profile to phthalates, which raises concern about the potential health hazards posed by such exposures. Research in our laboratory examines how phthalates interact with the female reproductive system in animal models to provide insights into the potential health effects of these chemicals in women. Here we review our work and the work of others studying these mechanisms and propose a model for the ovarian action of di-(2-ethylhexyl) phthalate (DEHP). In vivo, DEHP (2 g/kg) causes decreased serum estradiol levels, prolonged estrous cycles, and no ovulations in adult, cycling rats. In vitro, monoethylhexyl phthalate (MEHP; the active metabolite of DEHP) decreases granulosa cell aromatase RNA message and protein levels in a dose-dependent manner. MEHP is unique among the phthalates in its suppression of aromatase and in its ability to activate peroxisome proliferator-activated receptors (PPARs). We hypothesize that MEHP activates the PPARs to suppress aromatase in the granulosa cell. MEHP-, PPAR alpha-, and PPAR gamma-specific ligands all similarly decreased estradiol production and RNA message levels of aromatase in vitro. Our model shows that MEHP acts on the granulosa cell by decreasing cAMP stimulated by follicle stimulating hormone and by activating the PPARs, which leads to decreased aromatase transcription. Thus, the environmental contaminant DEHP, through its metabolite MEHP, acts through a receptor-mediated signaling pathway to suppress estradiol production in the ovary, leading to anovulation.

show abstract

“…Chronic occupational exposure to high levels of phthalates is associated with decreased rates of pregnancy and higher rates of miscarriage in female factory workers (Aldyreva et al, 1975). Higher urinary phthalates levels correlated with pregnancy complications such as anemia, toxemia, and preeclampsia in women living in close proximity to a plastics manufacturer (Tabacova et al, 1999).…”

Section: Discussionmentioning

confidence: 95%