36-Month Effectiveness of Ab-Interno Canaloplasty Standalone versus Combined with Cataract Surgery for the Treatment of Open-Angle Glaucoma

Gallardo, Mark J

doi:10.1016/j.ogla.2022.02.007

Cited by 13 publications

(17 citation statements)

References 23 publications

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“… 10 A subsequent report of outcomes at 36 months (44 eyes of 44 patients) confirmed the stability of IOP (baseline=20.5 mmHg; 12, 24, 36 months=13.3, 13.1, and 13.3 mmHg, respectively) and medication use (baseline=2.8; 12, 24, 36 months=1.1, 1.0, and 1.3, respectively). 11 Ondrejka et al reported 36-month outcomes for ab interno canaloplasty using the OSS or its predecessor, VISCO360, in a series of 206 eyes of 130 patients. Pre-operative baseline IOP was 21.1 mmHg on an average of 2.0 medications, which was reduced to an average of 15.3 mmHg on slightly less than 1 medication through the 36-month follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Canaloplasty and Trabeculotomy with the OMNI System in Patients with Open-Angle Glaucoma: Two-Year Results from the ROMEO Study

Williamson¹,

Vold²,

Campbell³

et al. 2023

OPTH

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Purpose To provide extended safety and effectiveness follow-up for eyes treated with circumferential canaloplasty and trabeculotomy (CP+TR) that were included in the 12-month ROMEO study. Setting Seven multi-subspecialty ophthalmology practices located in 6 states (Arkansas, California, Kansas, Louisiana, Missouri, and New York). Design Retrospective, multicenter, IRB approved. Subjects Eligible eyes had mild–moderate glaucoma and were treated with CP+TR with cataract surgery or as a standalone intervention. Methods Main outcome measures were mean IOP, mean number of ocular hypotensive medications, mean change in number of medications, proportion of patients with a ≥20% reduction in IOP or with IOP ≤18 mmHg, and proportion of patients medication free. Safety outcomes were adverse events and secondary surgical interventions (SSI). Results Eight surgeons at 7 centers contributed 72 patients stratified by pre-operative intraocular pressure (IOP); >18 mmHg (Grp1), ≤18 mmHg (Grp2). Mean follow-up of 2.1 years (min 1.4, max 3.5). 2-year IOP (SD) was 15.6 mmHg (−6.1 mmHg, −28% from baseline) on 1.4 medications (−0.9, −39%) for Grp1 with cataract surgery; 14.7 mmHg (−7.4 mmHg, −33% from baseline) on 1.6 medications (−0.7, −15%) for Grp1 standalone, 13.7 mmHg (−0.6 mmHg, −4.2%) on 1.2 medications (−0.8, −35%) for Grp2 with cataract surgery, 13.3 mmHg (−2.3 mmHg, −14.7%) on 1.2 medications (−1.0, −46%) for Grp2 standalone. The proportion of patients at 2 years with either a ≥20% IOP reduction or IOP between 6 and 18 mmHg and no increase in medication or SSI was 75% (54 of 72, 95% CI 69.9%, 80.1%). One-third of patients (24 of 72) were medication free whereas 9 of 72 were pre-surgical. No device-related adverse events during extended follow-up; 6 eyes (8.3%) required additional surgical or laser intervention for IOP control after 12 months. Conclusion CP+TR provides effective IOP control that is sustained for 2 years or more.

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Section: Discussionmentioning

confidence: 99%

Canaloplasty and Trabeculotomy with the OMNI System in Patients with Open-Angle Glaucoma: Two-Year Results from the ROMEO Study

Williamson¹,

Vold²,

Campbell³

et al. 2023

OPTH

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“…96 In adition, the study found no significant difference in surgical outcomes between phakic and pseudophakic eyes. 96 Outcome data regarding STREAMLINE and iPrime are currently lacking, given their recent release.…”

Section: Ab Interno Canaloplastymentioning

confidence: 75%

“…IOP spikes, microhyphema, hyphema, and mild AC inflammation were reported as complications in a minority of patients who underwent ABiC, irrespective of the devices used during the procedure. [96][97][98]…”

Section: Ab Interno Canaloplastymentioning

confidence: 99%

Minimally Invasive Glaucoma Surgery

Gallo Afflitto,

Swaminathan

2023

International Ophthalmology Clinics

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“…In the retrospective study by Liu et al[83], 1 eye (1.4%) required an anterior chamber washout for hyphema, 6 eyes (8.1%) required a reoperation within 3 months for unresolved IOP spikes, and 11 patients (18.6%) had BCVA loss >3 lines. Regarding AbiC complications, one retrospective study of 81 eyes that had AbiC surgery with the iTrack reported the following complications: microhyphema (12.3%), hyphema (3.7%), and IOP spike (3.7%) 7 …”

Section: Complications Of Goniotomymentioning

confidence: 99%