374 Long term effects of positive expiratory pressure (PEP) or oscillatory positive pressure (RC cornet®) on FEV1 and perceived health in children with CF

There was no clear evidence that oscillation was a more or less effective intervention overall than other forms of physiotherapy; furthermore there was no evidence that one device is superior to another. The findings from one study showing an increase in frequency of exacerbations requiring antibiotics whilst using an oscillating device compared to positive expiratory pressure may have significant resource implications. More adequately-powered long-term randomised controlled trials are necessary and outcomes measured should include frequency of exacerbations, individual preference, adherence to therapy and general satisfaction with treatment. Increased adherence to therapy may then lead to improvements in other parameters, such as exercise tolerance and respiratory function. Additional evidence is needed to evaluate whether oscillating devices combined with other forms of airway clearance is efficacious in people with cystic fibrosis.There may also be a requirement to consider the cost implication of devices over other forms of equally advantageous airway clearance techniques. Using the GRADE method to assess the quality of the evidence, we judged this to be low or very low quality, which suggests that further research is very likely to have an impact on confidence in any estimate of effect generated by future interventions.

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374 Long term effects of positive expiratory pressure (PEP) or oscillatory positive pressure (RC cornet®) on FEV1 and perceived health in children with CF

Cited by 4 publications

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Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis

Oscillating devices for airway clearance in people with cystic fibrosis

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