38.1: <i>Invited Paper:</i> Current Status and Future Prospect of In‐Cell Polarizer Technology

Ukai, Yasuhiro; Ohyama, Takeshi; Fennell, L.; Kato, Y.; Paukshto, Michael; Smith, Paul Jason; Yamashita, Osamu; Nakanishi, Shigemitsu

doi:10.1889/1.1821332

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…The aligned nanofibrillar collagen scaffolds were fabricated using shear-based fibrillogenesis technique 32,33 as described previously. 28 In brief, purified monomeric type I collagen solution was concentrated to reach a liquid crystal state [34][35][36][37] and then sheared onto a rigid surface, 38 creating thin film formed by parallel-aligned nanofibrils with 30-80 nm diameter.…”

Section: Fabrication and Characterization Of Aligned Nanofibrillar Scaffoldsmentioning

confidence: 99%

Aligned Nanofibrillar Scaffolds for Controlled Delivery of Modified mRNA

Zaitseva

Alcazar

Zamani

et al. 2019

Tissue Engineering Part A

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RNA-based vector delivery is a promising gene therapy approach. Recent advances in chemical modification of mRNA structure to form modified mRNA (mmRNA or cmRNA or modRNA) have substantially improved their stability and translational efficiency within cells. However, mmRNA conventionally delivered in solution can be taken up nonspecifically or become cleared away prematurely, which markedly limits the potential benefit of mmRNA therapy. To address this limitation, we developed mmRNA-incorporated nanofibrillar scaffolds that could target spatially localized delivery and temporally controlled release of the mmRNA both in vitro and in vivo. To establish the efficacy of mmRNA therapy, mmRNA encoding reporter proteins such as green fluorescence protein or firefly luciferase (Fluc) was loaded into aligned nanofibrillar collagen scaffolds. The mmRNA was released from mmRNA-loaded scaffolds in a transient and temporally controlled manner and induced transfection of human fibroblasts in a dose-dependent manner. In vitro transfection was further verified using mmRNA encoding the angiogenic growth factor, hepatocyte growth factor (HGF). Finally, scaffold-based delivery of HGF mmRNA to the site of surgically induced muscle injury in mice resulted in significantly higher vascular regeneration after 14 days, compared to implantation of Fluc mmRNA-releasing scaffolds. After transfection with Fluc mmRNA-releasing scaffold in vivo, Fluc activity was detectable and localized to the muscle region, based on noninvasive bioluminescence imaging. Scaffold-based local mmRNA delivery as an off-the-shelf form of gene therapy has broad translatability for treating a wide range of diseases or injuries.

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Section: Fabrication and Characterization Of Aligned Nanofibrillar Scaffoldsmentioning

confidence: 99%

Aligned Nanofibrillar Scaffolds for Controlled Delivery of Modified mRNA

Zaitseva

Alcazar

Zamani

et al. 2019

Tissue Engineering Part A

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“…Thin-crystal-film (TCF) polarizers have been developed for color TFT-LCDs [7]. TCF polarizers have several advantages over traditional polarizers.…”

Section: ] (A)polarizermentioning

confidence: 99%

5.2: Invited Paper: TFT‐LCDs as the Future Leading Role in FPD

Ukai¹

2013

Symp Digest of Tech Papers

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“…In case of flexible LCD, the external arrangement of polarizers may be ineffective at all, because of parasitical phase retardation of anisotropic polymer substrates. These problems can be avoided or strongly diminished by the ''in-cell'' location of optical films [1,2].…”

Section: Introductionmentioning

confidence: 99%