38-Month Long Progression-Free and Symptom-Free Survival of a Patient With Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used As a Stand-Alone Treatment after Failed Standard Oncotherapy

Abstract

Studies in animal models have suggested that the ketogenic diet may be effective in the treatment of cancer. However, human cohort studies on the ketogenic diet have, thus far, failed to show benefits in cancer survival or in any other hard clinical endpoints of the disease. This paper presents a case report of a patient with glioblastoma multiforme. The patient had initially been treated with standard oncotherapy including surgery, radiotherapy and chemotherapy. Despite standard treatment, the patient experienced a recurrence of the glioblastoma seven months later. Subsequently, the patient refused radiotherapy and chemotherapy and opted to use the paleolithic ketogenic diet (PKD) as a stand-alone therapy. Following the adoption of the PKD, progression of the disease has been completely halted. At the time of writing, the patient has remained in remission for 38 months, is without side-effects and experiences an excellent quality of life without the use of any drugs.

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“…Only a few very exceptional patient case reports exist from independent clinics which show prolonged survival and tumor shrinkage, however, these may be confounded by caloric and protein restriction, as well as standard treatment (drugs, radiotherapy, surgery) before, during and after the diet intervention. [143][144][145][146] These cases are also uncontrolled and fail to show whether or not the experimental treatment actually does better than conventional treatmentthis has been one criticism about these types of case studies. 147 More importantly, they severely suffer from conflicts of interest, survivorship and publication bias, as well as other biases.…”

“…One recent case report 144 being circulated by low-carb and keto advocates is of a patient with glioblastoma multiforme who received treatment at one of the independent clinics. He received conventional treatment (subtotal surgery, radiochemotherapy with TMZ) but months later an MRI showed recurrence.…”

The Paleolithic Ketogenic Diet (PKD) Is Associated with Low C-peptide Levels in Non-T1DM Patients and Healthy Subjects

“…Thus far, we have published several case reports of patients successfully treated with the PKD. These include: type 2 (Tóth and Clemens, 2015a) and type 1 diabetes (Tóth and Clemens, 2014;2015b), Crohn's disease ), Gilbert's syndrome (Tóth and Clemens, 2015c), epilepsy (Clemens et al, 2013(Clemens et al, , 2015; complete reversal of cervical intraepithelial neoplasia (Tóth et al, 2018); halted progression of soft palate cancer , regression of rectal cancer (Tóth and Clemens, 2017) and unexpectedly long survival with glioblastoma (Tóth et al, 2019). In 2017, we published a study with 50 patients on the PKD with 98% showing magnesium levels in the normal range, which is unexpected for a population with chronic diseases.…”