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Huang, Yi‐You; Wu, Shian-Min; Chen, Ming-Fong

doi:10.1023/a:1016089819967

Cited by 14 publications

(1 citation statement)

References 4 publications

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“…Although normal iontophoresis is done with the help of continuous DC current, pulsed waveform of DC has also been used, which has been able to produce significant and rapid delivery of drugs e.g., penetration of thyrotropic releasing hormone (TRH) was significantly increased when given by pulsed form than by continuous current [17]. Moreover, this has been found to be less damaging to the skin [18].…”

Section: Introductionmentioning

confidence: 99%

Iontophoresis - An Approach for Controlled Drug Delivery: A Review

Dixit¹,

Bali²,

Baboota³

et al. 2007

curr drug deliv

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The recent approval of lidocaine hydrochloride and epinephrine combined iontophoretic patch (Lidosite ® Vysteris Inc.) for localized pain treatment by FDA has invigorated the gaining interest in iontophoretic drug delivery systems for the transdermal delivery of drugs. This technique of facilitated movement of ions across a membrane under the influence of an externally applied electric potential difference, is one of the most promising physical skin penetration enhancing method. The rationale behind using this technique is the capability of this method to increase the systemic delivery of high molecular weight compounds with controlled input kinetics and minimum inter-subject variability, which is otherwise achieved only when parentral route of administration is used. Recently, good permeation of larger peptides like insulin has been achieved through this technique in combination with chemical enhancers. This review briefly describes the factors which affect iontophoretic drug delivery and summarizes the studies conducted recently using this technique in order to achieve higher systemic absorption of the drugs having low passive diffusion otherwise. The effect of permeation enhancers (chemical enhancers) on iontophoretic flux of drugs has also been described. Present review also provides an insight into reverse iontophoresis. Various parameters which affect the transdermal absorption of drugs through iontophoresis like drug concentration, polarity of drugs, pH of donor solution, presence of co-ions, ionic strength, electrode polarity etc. have also been reviewed in detail.

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Section: Introductionmentioning

confidence: 99%

Iontophoresis - An Approach for Controlled Drug Delivery: A Review

Dixit¹,

Bali²,

Baboota³

et al. 2007

curr drug deliv

View full text Add to dashboard Cite

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Enhanced transdermal delivery of a dipeptide by dermaportation

Namjoshi

Chen

Edwards³

et al. 2008

Biopolymers

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Poor skin permeability and stability limits the application of peptides to the skin. Enhanced skin permeation could offer new therapies for a range of dermatological and cosmetic applications. The aim of this study was to investigate the application of a novel magnetic field enhancement technology to peptide delivery across the skin. Ala-Trp was used as a model dipeptide. Stability of the dipeptide in a range of conditions and with exposure to skin was determined. Dermaportation-magnetic field technology increased the in vitro permeability coefficient of Ala-Trp across human epidermis from 7.7 x 10(-4) cm/h with passive diffusion to 1.94 x 10(-2) cm/h with Dermaportation. Ala-Trp was unstable with exposure to human epidermis. Following permeation across the epidermis, a degradation product was detected in the receptor solution with the amount increasing up to 6 h. Given the susceptibility of peptides to degradation in the skin it is essential that they are delivered rapidly across the skin in order to maximize the opportunity for delivery of the native peptide. Dermaportation offers a potential new delivery method for skin delivery of peptides for a range of dermatological and cosmetic applications.

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