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Belikov, V. G.; Kuregyan, A. G.; Ismailova, G. K.

doi:10.1023/a:1020845110683

Cited by 15 publications

(4 citation statements)

References 3 publications

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“…Magnetite content in magnetoliposomes was determined through the method described by Belikov et al Triton‐X 10% (w/v) detergent solution was added to an opportune amount of magnetite solution to disrupt the phospholipid vesicles. The volume was adjusted to 5 mL with 8.5% HCl, and the absorbance was read at a wavelength of 320 nm in a Lambda 25 spectrophotometer (Perkin Elmer, USA).…”

Section: Methodsmentioning

confidence: 99%

Preparation and characterization of lipid vesicles entrapping iron oxide nanoparticles

Petralito

Spera

Memoli

et al. 2012

Asia-Pacific J Chem Eng

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Nanometric assemblies, activated and controlled through external stimuli, represent an innovative stage in the development of multifunctional therapeutics. In particular, magnetite nanoparticles embedded in liposomes represent submicrometric carriers that can be activated by external magnetic fields, showing high efficacy in reaching tumor cells offering new exciting opportunities towards the development of active targeting systems. Actually, synthesis and characterization of such nanoscale carriers, as well as the assessment of their entrapment capacity, is of great interest for the scientific community. We report here the formation and the characterization of magnetoliposomes (MLs): phospholipid vesicles encapsulating magnetite nanoparticles. MLs were prepared by embedding hydrophilic nanoparticles of commercially available carboxymethyl-dextran coated superparamagnetic iron oxide particles inside the vesicles at different lipid/nanoparticles ratios. Liposomes were prepared by the thin lipid film hydration method: a fixed amount of lipids was dissolved in organic solvent and the obtained solution was evaporated until dryness. Then the dry lipid film was hydrated with a buffered aqueous solution of different concentrations of carboxymethyl-dextran coated magnetite. The resulting MLs, heterogeneous in their size, were extruded through polycarbonate membranes to obtain homogeneous size of unilamellar vesicles. Size exclusion chromatography was used to remove non-entrapped nanoparticles. Magnetite content was determined by 1,10-phenanthroline (Kiwada assay) and Belikov methods and also by flame absorption spectrometry. Physical characterization was performed by dynamic light scattering to determine the mean particles diameter, the size distribution, and the ζ-potential. Physical stability of MLs stored at 4 °C was investigated up to 4 weeks to assess the effect on time of the entrapment of the nanoparticles within the liposomes. © 2012 Curtin University of Technology and John Wiley & Sons, Ltd

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Section: Methodsmentioning

confidence: 99%

Preparation and characterization of lipid vesicles entrapping iron oxide nanoparticles

Petralito

Spera

Memoli

et al. 2012

Asia-Pacific J Chem Eng

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“…Although MNPs have many uses, the main challenges faced by researches working with magnetite NPs include, stability 16 , maintenance of crystallinity of the particles etc. Targeted drug delivery using magnetite makes way for drug delivery at site as well as reduced side effects with controlled release of drug for prolonged time 17 . Magnetite nanoparticles coated with polymers have been used to carry doxorubicin and 5-fluorouracil and also evaluated in vitro [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Coated Coreshell Magnetite Nanoparticles for Rifampicin Delivery

et al. 2018

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In this study, chemically synthesized magnetite was produced where the size was found to be size between 50 and 60nm with para ferro magnetic property. Coreshell magnetite nanoparticles was produced with initial coating of rifampicin by ultrasonication and was encapsulated with any of one among four different biopolymers namely chitosan, starch, casein and polyhydroxybutyrate (PHB). Coreshell nanoparticles were analysed for their drug loading efficiency and drug release studies. PHB and chitosan loaded particles were observed to release drug steadily. All the biopolymer coated nanoparticles were subjected to antibacterial activity against Klebsiella sp by agar well diffusion method. PHB and chitosan coating of the particles were found to be the best for holding rifampicin. Magnetite was subjected for MTT based cytotoxicity assay against peripheral mononuclear cells and its LC50 was found at 60 µg/ml.

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“…Several reasons have been considered for difficulties to prepare perfect encapsulation magnetic microspheres, one of the most important reasons is the poor suspension of magnetic particles in oil phase. The surface of inorganic particles, such as TiO 2 , iron oxide etc, has some hydroxyls [15][16][17][18][19], they are hydrophilic, so it is difficult for magnetic particles to disperse in the oil uniformly. In other words, as the polar difference between the hydrophilic inorganic particles and the hydrophobic monomer, it is difficult to disperse the inorganic particles in the oil phase and lead to the poor encapsulation of magnetic composite spheres.…”

Section: Introductionmentioning

confidence: 99%

Preparation of magnetic composite microspheres by surfactant free controlled radical polymerization: Preparation and characteristics

Zhang

et al. 2009

Journal of Magnetism and Magnetic Materials

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Untitled

Cited by 15 publications

References 3 publications

Preparation and characterization of lipid vesicles entrapping iron oxide nanoparticles

Preparation and characterization of lipid vesicles entrapping iron oxide nanoparticles

Biopolymer Coated Coreshell Magnetite Nanoparticles for Rifampicin Delivery

Preparation of magnetic composite microspheres by surfactant free controlled radical polymerization: Preparation and characteristics

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