3D aerogel of cellulose triacetate with supercritical antisolvent process for drug delivery

Wang, Cheng; Okubayashi, Satoko

doi:10.1016/j.supflu.2019.02.026

Cited by 27 publications

(5 citation statements)

References 38 publications

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“…To meet the requirements of the final application, the properties of the aerogels should be improved in order to achieve non-toxicity, sustainability, biocompatibility, and biodegradability. This can be achieved by combining polysaccharides with other components that can extend the material application [ 134 ]. In addition, the hybrid aerogels with molecular-aggregate level compositions exhibit unique, folded microstructures and enhanced mechanical properties [ 135 ].…”

Section: Applicationsmentioning

confidence: 99%

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Muhammad¹,

Lee²,

Shin³

et al. 2021

Polymers

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Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.

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Section: Applicationsmentioning

confidence: 99%

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Muhammad¹,

Lee²,

Shin³

et al. 2021

Polymers

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“…As time progressed, the matrix changed with large sizes of pores in the inner region due to the erosion of the polymeric matrix. Then, this erosion controls the release with a slow drug release ratio [ 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation of Vancomycin-Loaded Aerogels Implementing Inkjet Printing and Superhydrophobic Surfaces

Remuiñán-Pose

López‐Iglesias²,

Iglesias-Mejuto³

et al. 2022

Gels

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Chronic wounds are physical traumas that significantly impair the quality of life of over 40 million patients worldwide. Aerogels are nanostructured dry porous materials that can act as carriers for the local delivery of bioactive compounds at the wound site. However, aerogels are usually obtained with low drug loading yields and poor particle size reproducibility and urges the implementation of novel and high-performance processing strategies. In this work, alginate aerogel particles loaded with vancomycin, an antibiotic used for the treatment of Staphylococcus aureus infections, were obtained through aerogel technology combined with gel inkjet printing and water-repellent surfaces. Alginate aerogel particles showed high porosity, large surface area, a well-defined spherical shape and a reproducible size (609 ± 37 μm). Aerogel formulation with vancomycin loadings of up to 33.01 ± 0.47 μg drug/mg of particle were obtained with sustained-release profiles from alginate aerogels for more than 7 days (PBS pH 7.4 medium). Overall, this novel green aerogel processing strategy allowed us to obtain nanostructured drug delivery systems with improved drug loading yields that can enhance the current antibacterial treatments for chronic wounds.

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“…The method of loading the drug at the preparation stage is to add the drug to the biopolymer solution before the gelation stage. In this way, it is possible to obtain materials where the drug is chemically or physically bound to the solid phase [ 23 , 26 , 27 ]. There are a number of limitations for carrying out this loading method.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems

Lovskaya

Bezchasnyuk

Mochalova

et al. 2022

Gels

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The research was oriented towards the preparation of aerogel particles based on egg white and whey protein isolate using various dispersion methods: dripping, spraying, and homogenization. Based on the results of analytical studies, the most appropriate samples were selected to obtain aerogels loaded with the drug. The results of the experimental research were used to study methods for obtaining nasal drug delivery systems based on aerogels. Protein aerogels were obtained by thermal gelation followed by supercritical drying. The obtained particles of protein aerogels have a specific surface area of up to 350 m2/g with a pore volume of up to 2.9 cm3/g, as well as a porosity of up to 95%. The results of experimental studies have shown that changing the dispersion method makes it possible to control the structural characteristics of protein aerogel particles. The results of the studies were applied to obtain innovative nasal drug delivery systems for the treatment of socially significant diseases. Analytical studies were conducted to determine the amount and state of adsorbed drugs in protein aerogel particles, as well as in vivo experiments on the distribution of clomipramine in blood plasma and brain tissue of rats to study the pharmacokinetics and bioavailability of the resulting drug-loaded protein aerogel.

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3D aerogel of cellulose triacetate with supercritical antisolvent process for drug delivery

Cited by 27 publications

References 38 publications

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Preparation of Vancomycin-Loaded Aerogels Implementing Inkjet Printing and Superhydrophobic Surfaces

Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems

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