3D and 4D bioprinted human model patenting and the future of drug development

Mota, Fábio Batista; Braga, Luiza Amara Maciel; Rocha, Leonardo Fernandes Moutinho; Cabral, Bernardo Pereira

doi:10.1038/s41587-020-0540-1

Cited by 26 publications

(25 citation statements)

References 36 publications

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“…After uploading, the number of emails was further reduced to 37 833 due to previous opted‐out contacts in the SurveyMonkey's database and bounced emails. Other works that use a similar strategy have found satisfactory results 16 …”

Section: Methodsmentioning

confidence: 93%

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Probing expert opinions on the future of kidney replacement therapies

et al. 2020

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Patients with kidney failure can only survive with some form of kidney replacement (transplant or dialysis). Unfortunately, innovations in kidney replacement therapy lag behind many other medical fields. This study compiles expert opinions on candidate technologies for future kidney replacement therapies. A worldwide web‐based survey was conducted with 1566 responding experts, identified from scientific publications on kidney (renal) replacement therapy, indexed in the Web of Science Core Collection (period 2014‐2019). Candidate innovative approaches were categorized in line with the Kidney Health Initiative roadmap for innovative kidney replacement therapies. Most respondents expected a revolution in kidney replacement therapies: 68.59% before 2040 and 24.85% after 2040, while 6.56% expected none. Approaches anticipated as most likely were implantable artificial kidneys (38.6%) and wearable artificial kidneys (32.4%). A majority of experts expect that kidney replacement therapies can be significantly improved by innovative technologies.

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Section: Methodsmentioning

confidence: 93%

“…Other works that use a similar strategy have found satisfactory results. 16 The questionnaire (Table 1) considered a future horizon of 20 years (2020-2040) and was structured in four parts. The first part informed the respondents about the purpose of the survey, data collection, confidentiality, privacy, and consent.…”

Section: Methodsmentioning

confidence: 99%

Probing expert opinions on the future of kidney replacement therapies

et al. 2020

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“…The road developing a multi-organ connection is still extremely tangled and far to reach a real HOC system. However, the advent of new encouraging technologies, such as 3D bioprinting (Mota et al, 2020), mathematical models of networks (Cao et al, 2018;Wang Y. et al, 2019) and systems biology (Li et al, 2020), will represent relevant resources to reach this revolutionary scope.…”

Section: Discussionmentioning

confidence: 99%

Oncoimmunology Meets Organs-on-Chip

Mattei

Andreone

Mencattini

et al. 2021

Front. Mol. Biosci.

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Oncoimmunology represents a biomedical research discipline coined to study the roles of immune system in cancer progression with the aim of discovering novel strategies to arm it against the malignancy. Infiltration of immune cells within the tumor microenvironment is an early event that results in the establishment of a dynamic cross-talk. Here, immune cells sense antigenic cues to mount a specific anti-tumor response while cancer cells emanate inhibitory signals to dampen it. Animals models have led to giant steps in this research context, and several tools to investigate the effect of immune infiltration in the tumor microenvironment are currently available. However, the use of animals represents a challenge due to ethical issues and long duration of experiments. Organs-on-chip are innovative tools not only to study how cells derived from different organs interact with each other, but also to investigate on the crosstalk between immune cells and different types of cancer cells. In this review, we describe the state-of-the-art of microfluidics and the impact of OOC in the field of oncoimmunology underlining the importance of this system in the advancements on the complexity of tumor microenvironment.

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“…Natural science publications are best suited for this type of study, where the aim is to foresee future uses of a given technology. [18][19][20] To prioritize these publications, we included only the Science Citation Index Expanded (SCI-Expanded)-99% of all gene editing-related publications were indexed in the SCI-Expanded. The search strategy covered two parts.…”

Section: Methodsmentioning

confidence: 99%

“…We opted to not include demographic questions in the survey because respondents' characteristics such as age, gender, ethnicity, employment, location are not expected to influence the results. [18][19][20] To avoid respondents' fatigue, skipped questions, and survey dropout, we set the questionnaire to be answered within 2-3 min.…”

Section: Methodsmentioning

confidence: 99%

Gene Editing for Treatment and Prevention of Human Diseases: A Global Survey of Gene Editing-Related Researchers

2020

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In the next decades, gene editing technologies are expected to be used in the treatment and prevention of human diseases. Yet, the future uses of gene editing in medicine are still unknown, including its applicability and effectiveness to the treatment and prevention of infectious diseases, cancer, and monogenic and polygenic hereditary diseases. This study aims to address this gap by analyzing the views of over 1,000 gene editing-related researchers from all over the world. Some of our survey results show that, in the next 10 years, DNA double-strand breaks are expected to be the main method for gene editing, and CRISPR-Cas systems to be the mainstream programmable nuclease. In the same period, gene editing is expected to have more applicability and effectiveness to treat and prevent infectious diseases and cancer. Off-targeting mutations, reaching therapeutic levels of editing efficiency, difficulties in targeting specific tissues in vivo, and regulatory and ethical challenges are among the most relevant factors that might hamper the use of gene editing in humans. In conclusion, our results suggest that gene editing might become a reality to the treatment and prevention of a variety of human diseases in the coming 10 years. If the future confirms these researchers' expectations, gene editing could change the way medicine, health systems, and public health deal with the treatment and prevention of human diseases.

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3D and 4D bioprinted human model patenting and the future of drug development

Cited by 26 publications

References 36 publications

Probing expert opinions on the future of kidney replacement therapies

Probing expert opinions on the future of kidney replacement therapies

Oncoimmunology Meets Organs-on-Chip

Gene Editing for Treatment and Prevention of Human Diseases: A Global Survey of Gene Editing-Related Researchers

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