Resumo. O presente artigo apresenta uma revisão crítica da literatura acerca do conceito e de estudos realizados sobre o fenômeno bullying ou vitimização entre pares na escola. Em primeiro lugar, apresenta-se uma definição do construto bullying, salientando-se problemas de tradução e outros termos usados para definir este tipo de violência em outras culturas e na língua portuguesa. Enfatiza-se, nesta primeira parte do artigo, a perspectiva teórica que se adota para análise do fenômeno. Em seguida, explicam-se e detalham-se as formas de manifestação do bullying protagonizado ou sofrido por crianças e adolescentes, as diferenças de gênero percebidas e os papéis sociais na dinâmica do bullying estudados por alguns autores. Apresentam-se, ainda, fatores de risco envolvidos no processo de bullying tanto como possíveis causas ou desencadeadores desse fenômeno, quanto como consequências dele. Por fim, retomam-se pontos apresentados e focaliza-se a problemática do bullying e suas proporções no contexto atual. A partir disso, sugerem-se, para discussão e reflexão, algumas ideias sobre formas de prevenção e intervenção desse tipo de comportamento agressivo. Palavras-chave: bullying, definições, fatores de risco, intervenção.Abstract. The present paper presents a critical literature revision about the concept and studies toward bullying phenomenon in school contexts. First, it will be presented a definition of bullying, emphasizing translation problems to this word as well as other words used to define this type of violence in other cultures and in Portuguese speaking countries. Moreover, the theoretical perspective of analysis adopted in this specific work will be emphasized. Following, manifestation expressions of bullying, initiated or suffered by children and adolescents will be explained, as well as some gender differences and social roles assumed by the participants in the bullying process, according to some authors. Risk factors of the bullying process will also be pointed as possible causes to the phenomenon as well as consequences to the participants. Finally, the ideas presented will be reviewed and emphasized the bullying problem and its magnitude nowadays. Therefore, ideas to prevention and intervention actions of this kind of aggressive behavior will be open to discussion.

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This article aims to map the scientific production concerning the inclusion of people with disabilities in Science Education to promote a reflection on the production of this area. Bibliometric analysis is used to help understand what stage of research a particular subject is at. Publications on the topic indexed at the Web of Science Core Collection (WoS) were evaluated. A total of 119 articles published between 2009 and July 2019 were selected as dealing specifically with the subject. An increase in the number of articles associating Science teaching (ST) and Inclusive Education (IE) was noted. The journals that published the most, the most productive authors in the area and their collaboration networks were identified. A content analysis of the research was also carried out and the main investigated topics were pointed out. Educational levels, types of disabilities, central themes and specific science areas prevailing in the mapped research were also indicated. We conclude that, despite the growing number of articles, scientific production associating SE and IE is still small, concentrated, and not shared with the scientific community through scientific education journals, and that most research is focused on the use of methodologies and resources, and not on their development.

Introduction: Rare genetic diseases affect millions of people worldwide. Most of them are caused by defective genes that impair quality of life and can lead to premature death. As genetic therapies aim to fix or replace defective genes, they are considered the most promising treatment for rare genetic diseases. Yet, as these therapies are still under development, it is still unclear whether they will be successful in treating these diseases. This study aims to address this gap by assessing researchers’ opinions on the future of genetic therapies for the treatment of rare genetic diseases. Methods: We conducted a global cross-sectional web-based survey of researchers who recently authored peer-reviewed articles related to rare genetic diseases. Results: We assessed the opinions of 1430 researchers with high and good knowledge about genetic therapies for the treatment of rare genetic diseases. Overall, the respondents believed that genetic therapies would be the standard of care for rare genetic diseases before 2036, leading to cures after this period. CRISPR-Cas9 was considered the most likely approach to fixing or replacing defective genes in the next 15 years. The respondents with good knowledge believed that genetic therapies would only have long-lasting effects after 2036, while those with high knowledge were divided on this issue. The respondents with good knowledge on the subject believed that non-viral vectors are more likely to be successful in fixing or replacing defective genes in the next 15 years, while most of the respondents with high knowledge believed viral vectors would be more successful. Conclusion: Overall, the researchers who participated in this study expect that in the future genetic therapies will greatly benefit the treatment of patients with rare genetic diseases. Plain Language Summary A global survey of researchers on the future of genetic therapies for rare genetic diseases Rare genetic diseases are caused by defective genes that result from one or more mutations in the genome. Today, the therapeutic options for these diseases are limited, and there are approved treatments for about 5% of them. In the future, genetic therapies (a group of techniques developed to correct defective genes) are expected to revolutionize the treatment of rare genetic diseases. Although promising, most of these therapies are currently under development and have a long way to go before their efficacy and safety can be proved. The uncertainty surrounding this topic therefore means the success of genetic therapies in treating or curing rare genetic diseases is not yet assured. To address this knowledge gap, we surveyed 1430 researchers working in rare genetic diseases about the future of genetic therapies for the treatment of these diseases over the next 15 years. Most of them expected gene therapies to be the standard of care for rare genetic diseases before 2036 and to be able to cure them after this date. CRISPR-Cas9 was felt to be the gene editing approach that was most likely to succeed in fixing or replacing defective genes in the next 15 years. The respondents with high knowledge about gene therapies for the treatment of rare diseases believed gene therapies would have long-lasting effects before 2036, while those with good knowledge expected this to be the case only after 2036. The former believed in viral vectors and the latter in non-viral vectors to fix or replace defective genes in the next 15 years.

In the next decades, gene editing technologies are expected to be used in the treatment and prevention of human diseases. Yet, the future uses of gene editing in medicine are still unknown, including its applicability and effectiveness to the treatment and prevention of infectious diseases, cancer, and monogenic and polygenic hereditary diseases. This study aims to address this gap by analyzing the views of over 1,000 gene editing-related researchers from all over the world. Some of our survey results show that, in the next 10 years, DNA double-strand breaks are expected to be the main method for gene editing, and CRISPR-Cas systems to be the mainstream programmable nuclease. In the same period, gene editing is expected to have more applicability and effectiveness to treat and prevent infectious diseases and cancer. Off-targeting mutations, reaching therapeutic levels of editing efficiency, difficulties in targeting specific tissues in vivo, and regulatory and ethical challenges are among the most relevant factors that might hamper the use of gene editing in humans. In conclusion, our results suggest that gene editing might become a reality to the treatment and prevention of a variety of human diseases in the coming 10 years. If the future confirms these researchers' expectations, gene editing could change the way medicine, health systems, and public health deal with the treatment and prevention of human diseases.