3D bioprinted hyaluronic acid-based cell-laden scaffold for brain microenvironment simulation

Li, Yuting; Wu, Yutong; Yu, Mengfei; Aazmi, Abdellah; Gao, Lei; Xue, Qingwu; Luo, Yichen; Zhou, Hongzhao; Zhang, Bin; Yang, Huayong

doi:10.1007/s42242-020-00076-6

Cited by 33 publications

(30 citation statements)

References 40 publications

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“…[ 102 ] The term of shape memory effect (SME) refers to the ability of the shape memory alloys (SMAs) to achieve the transformation between two or several crystallographic phases through diffusion‐less transformations (the so‐called “reversible martensitic transformations” [ 103 ] ). Presently, the smart SRMs include SMAs, [ 104 ] shape memory ceramics (SMCrs), [ 64,105 ] SMPs, [ 28,106 ] LCPs, [ 107 ] stimuli‐responsive hydrogels, [ 86,108 ] and composites containing shape‐changing materials. The SME can be extended to the ability of all SMMs that memorize temporary shape(s) and revert to their permanent shape upon exposure to an external stimulus; during the process, the external stimuli energy, such as heat and light, is converted into a change in strain.…”

Section: Polymeric Materials Employed In 4d Printing and Applicable P...mentioning

confidence: 99%

“…SMAs have thoroughly demonstrated their unique advantages over both irreversible and super mechanical properties, making them a superior class of actuation materials. [ 104b ] The SMCrs with oligocrystalline structures possess a set of unique properties, including high energy output and high‐temperature usage. [ 64 ] Generally, the SMAs and SMCrs have potential clinical applications for smart bone implants due to their high mechanical modulus.…”

Section: Polymeric Materials Employed In 4d Printing and Applicable P...mentioning

confidence: 99%

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Emerging 4D Printing Strategies for Next‐Generation Tissue Regeneration and Medical Devices

et al. 2022

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printing. First introduced by Massachusetts Institute of Technology researcher Skylar Tibbits during a Technology, Entertainment, Design (TED) talk in 2013, and then subsequently expanded upon in published research, [2] 4D printing has gained substantial research attention in recent years and has become the subject matter of a substantial number of recent publications (Figure 1).The additional dimension over 3D printing, namely, the 4th dimension, is a time component. [3] Therein, 4D printing can be defined as a 3D printed structure that can self-transform in shape, properties, and/or functionality when exposed to predetermined stimuli, such as light, [4] heat, applied magnetic field (MF), [5] or electrical field (EF), [6] changes in pH, [7] and/or various combinations thereof postprinting. [8] Since its invention, the 4D printing approach has been utilized for multitudinous applications, such as the fabrication of sensors, [9] actuators, [10] soft robotics, [11] biomedical scaffolds/devices, drug delivery systems, [12] and others. [13] Presently, 4D printing, which is still in its infancy, has become an exciting branch of AM and has spurred great interest from both academia and industry alike. [14] In this review article, we present a general overview of the 4D printing field and recent achievements. Our review includes the discussion on the structural design of 4D printing,The rapid development of 3D printing has led to considerable progress in the field of biomedical engineering. Notably, 4D printing provides a potential strategy to achieve a time-dependent physical change within tissue scaffolds or replicate the dynamic biological behaviors of native tissues for smart tissue regeneration and the fabrication of medical devices. The fabricated stimulusresponsive structures can offer dynamic, reprogrammable deformation or actuation to mimic complex physical, biochemical, and mechanical processes of native tissues. Although there is notable progress made in the development of the 4D printing approach for various biomedical applications, its more broad-scale adoption for clinical use and tissue engineering purposes is complicated by a notable limitation of printable smart materials and the simplistic nature of achievable responses possible with current sources of stimulation. In this review, the recent progress made in the field of 4D printing by discussing the various printing mechanisms that are achieved with great emphasis on smart ink mechanisms of 4D actuation, construct structural design, and printing technologies, is highlighted. Recent 4D printing studies which focus on the applications of tissue/organ regeneration and medical devices are then summarized. Finally, the current challenges and future perspectives of 4D printing are also discussed.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202109198.

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Section: Polymeric Materials Employed In 4d Printing and Applicable P...mentioning

confidence: 99%

Section: Polymeric Materials Employed In 4d Printing and Applicable P...mentioning

confidence: 99%

Emerging 4D Printing Strategies for Next‐Generation Tissue Regeneration and Medical Devices

et al. 2022

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“…Besides synthetic hydrogels, natural hydrogels such as gelatin ( Hsieh and Hsu, 2019 ), collagen ( Diamantides et al., 2017 ), Matrigel ( Berg et al., 2018 ), fibrin ( Bayat et al., 2018 ), hyaluronic acids ( Bonnesoeur et al., 2020 ; Ma et al., 2020a ), and decellularized ECM (dECM) can offer a biomimetic microenvironment ( Koh et al., 2018 ). In a work, Xu et al.…”

Section: In Vitro Models Of the Bbbmentioning

confidence: 99%

“…Therefore, research advances showed to be dispersed, not fully connected, and limited by dissociated parameters set to create the in vitro model. Creating vascularized in vitro models is now considered as a more accurate approach to recreate different in vivo organs and pathologies ( Li et al., 2021b ; Ma et al., 2020a ). Remarkably, the brain vasculature is an important aspect of the brain that has recently attracted increasing attention because of the need to replicate its intricate functions and structure.…”

Section: Introductionmentioning

confidence: 99%

Vascularizing the brain in vitro

Aazmi

Zhou

et al. 2022

iScience

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“…The technique allows the low-cost and high-precision fabrication of cell-laden scaffolds with high cell viability[ 12 ]. Advancements based on this technology have been demonstrated, including mandible bones[ 7 ], liver tissue[ 13 ], cardiac patches[ 14 ], brain microenvironment[ 15 ], and multi-layered skin[ 16 ].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Thermal Analysis for Accurately Predicting the Extrusion Printability of Alginate–Gelatin-Based Hydrogel Bioinks

Zhang

Xue

et al. 2021

IJB

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Three-dimensional (3D) bioprinting has significant potential for addressing the global problem of organ shortages. Extrusion printing is a versatile 3D bioprinting technique, but its low accuracy currently limits the solution. This lack of precision is attributed largely to the complex thermal and dynamic properties of bioinks and makes it difficult to provide accurate estimations of the printed results. It is necessary to understand the relationship between printing temperature and materials’ printability to address this issue. This paper proposes a quantitative thermal model incorporating a system’s printing temperatures (syringe, ambient, and bioink) to facilitate accurate estimations of the printing outcomes. A physical model was established to reveal the relationship between temperature, pressure, and velocity in guiding the printing of sodium alginate–gelatin composite hydrogel (a popular bioink) to optimize its extrusion-based printability. The model considered the phenomenon of bioink die swells after extrusion. A series of extrusion experiments confirmed that the proposed model offers enhanced printing outcome estimations compared with conventional models. Two types of nozzles (32- and 23-gauge) were used to print several sets of lines with a linewidth step of 50 μm by regulating the extrudate’s temperature, pressure, and velocity separately. The study confirmed the potential for establishing a reasonable, accurate open-loop linewidth control based on the proposed optimization method to expand the application of extrusion-based bioprinting further.

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3D bioprinted hyaluronic acid-based cell-laden scaffold for brain microenvironment simulation

Cited by 33 publications

References 40 publications

Emerging 4D Printing Strategies for Next‐Generation Tissue Regeneration and Medical Devices

Emerging 4D Printing Strategies for Next‐Generation Tissue Regeneration and Medical Devices

Vascularizing the brain in vitro

A Systematic Thermal Analysis for Accurately Predicting the Extrusion Printability of Alginate–Gelatin-Based Hydrogel Bioinks

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