3D bioprinting and Rigenera® micrografting technology: A possible countermeasure for wound healing in spaceflight

Abstract

Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra-generational changes in the quality of life. These include reduced bone calcium levels and muscle tone, provoking skin deterioration. All these problems reduce the work efficiency and quality of life of humans not only during exposure to microgravity (µG) but also after returning to Earth. This article discusses forthcoming experiments required under gravity and µG conditions to ensure effective and successful medical treatments for astronauts during long-term space missions, where healthcare is difficult and not guaranteed.

Biological Evidence of Improved Wound Healing Using Autologous Micrografts in a Diabetic Animal Model

“…Rigenera ® technology (Human Brain Wave, Turin, Italy) is now a currently available alternative technology for obtaining micrografts (namely progenitor cells (PCs) within their own extracellular matrix) involving disposable medical devices as mechanical disruptors of biological tissues [37][38][39][40][41][42][43][44][45]. It allows for obtaining micrografts in an autologous, homologous, and minimally invasive manner, and these can be used immediately without the need for culture cells.…”

Short-Term Clinical Assessment of Treating Female Androgenetic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles

“…All devices are CE-certified as Class I medical devices [25]. The protocol for regenerating tissues is described in various publications [26][27][28][29].…”

Long-term results of autologous periosteum-derived micro-grafts with poly(lactic-go-glycolic acid) in sinus lift augmentation surgeries: A 7-years follow-up observational study

“…The principle of selection of micrografts is based on a mechanism of dimensional exclusion, namely, everything that measures 80 μm passes through the holes of the grid and is collected in the reservoir below, the larger tissue remains on the grid. The disintegration process requires the addition of 1 ml of saline solution (0.9 % NaCl) from the dedicated hole on the device [12] , [13] , [14] , [15] , [16] .…”

“…In this observational follow-up study [3] , [4] , the biological component is provided by the presence of periosteum-derived autologous and homologous micrografts, obtained through the Rigenera® technology, which uses class II medical devices, already widely used in various areas concerning tissue regeneration, including dental, orthopedic, dermatological, wound healing, and cardiac field [10] , [11] , [12] , [13] .…”