3d-Echocardiography Demonstrates Excellent Correlation With Cardiac Magnetic Resonance for Assessment of Left Ventricular Function and Volumes in a Model of Myocardial Infarction

Santos‐Gallego, Carlos G.; Vahl, Torsten; Gaebelt, Hans Paul; López, María Isabel Sánchez; Ares-Carrasco, Sara; Sanz, Javier; Goldman, Martin E.; Hajjar, Roger J.; Fuster, Valentín; Badimón, Juan J.

doi:10.1016/s0735-1097(12)61565-4

Cited by 4 publications

(5 citation statements)

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“…In terms of direct comparisons of cardiac parameter values obtained using echocardiography with those obtained by cardiac MRI, numerous earlier studies have found that echocardiography tends to underestimate cardiac volumes as compared to MRI [20][21][22][23][24][25][26][27][28][29][30][31]. However, there are several studies that have shown excellent volume correlations between the two techniques in animal models [32,33] and good correlations for LVEF assessments in human patients [23]. As previous studies showed that echocardiography provides systematically lower value estimates for cardiac volumes (as compared to MRI), our current study aimed to test these findings in a mixed cohort of AF patients (with and without fibrosis) and healthy controls, which have a large span of values for the assessed cardiac parameters.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Volumes Determined by Echocardiography and Cardiac MRI in Controls and Atrial Fibrillation Patients

Manole

Budurea

Pop

et al. 2021

Life

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Aims: We aimed to compare cardiac volumes measured with echocardiography (echo) and cardiac magnetic resonance imaging (MRI) in a mixed cohort of healthy controls (controls) and patients with atrial fibrillation (AF). Materials and methods: In total, 123 subjects were included in our study; 99 full datasets were analyzed. All the participants underwent clinical evaluation, EKG, echo, and cardiac MRI acquisition. Participants with full clinical data were grouped into 63 AF patients and 36 controls for calculation of left atrial volume (LA Vol) and 51 AF patients and 30 controls for calculation of left ventricular end-diastolic volume (LV EDV), end-systolic volume (ESV), and LV ejection fraction (LV EF). Results: No significant differences in LA Vol were observed (p > 0.05) when measured by either echo or MRI. However, echo provided significantly lower values for left ventricular volume (p < 0.0001). The echo LA Vol of all the subjects correlated well with that measured by MRI (Spearmen correlation coefficient r = 0.83, p < 0.0001). When comparing the two methods, significant positive correlations of EDV (all subjects: r = 0.55; Controls: r = 0.71; and AF patients: r = 0.51) and ESV (all subjects: r = 0.62; Controls: r = 0.47; and AF patients: r = 0.66) were found, with a negative bias for values determined using echo. For a subgroup of participants with ventricular volumes smaller than 49.50 mL, this bias was missing, thus in this case echocardiography could be used as an alternative for MRI. Conclusion: Good correlation and reduced bias were observed for LA Vol and EF determined by echo as compared to cardiac MRI in a mixed cohort of patients with AF and healthy volunteers. For the determination of volume values below 49.50 mL, an excellent correlation was observed between values obtained using echo and MRI, with comparatively reduced bias for the volumes determined by echo. Therefore, in certain cases, echocardiography could be used as a less expensive, less time-consuming, and contraindication free alternative to MRI for cardiac volume determination.

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Section: Introductionmentioning

confidence: 99%

Correlation between Volumes Determined by Echocardiography and Cardiac MRI in Controls and Atrial Fibrillation Patients

Manole

Budurea

Pop

et al. 2021

Life

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“…This problem can be solved by using 3D echocardiography to obtain 3D images of the complete left ventricle. In pigs, LVEF assessment by epicardial 3D echocardiography shows excellent correlation with gold-standard CMRI 24,32 . However, this requires surgery prior to AMI induction for baseline measurements.…”

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confidence: 87%

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Ellenbroek

Hout

Timmers

et al. 2016

JoVE

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Mortality after acute myocardial infarction remains substantial and is associated with significant morbidity, like heart failure. Novel therapeutics are therefore required to confine cardiac damage, promote survival and reduce the disease burden of heart failure. Large animal experiments are an essential part in the translational process from experimental to clinical therapies. To optimize clinical translation, robust and representative outcome measures are mandatory. The present manuscript aims to address this need by describing the assessment of three clinically relevant outcome modalities in a pig acute myocardial infarction (AMI) model: infarct size in relation to area at risk (IS/AAR) staining, 3-dimensional transesophageal echocardiography (TEE) and admittance-based pressure-volume (PV) loops. Infarct size is the main determinant driving the transition from AMI to heart failure and can be quantified by IS/AAR staining. Echocardiography is a reliable and robust tool in the assessment of global and regional cardiac function in clinical cardiology. Here, a method for three-dimensional transesophageal echocardiography (3D-TEE) in pigs is provided. Extensive insight into cardiac performance can be obtained by admittance-based pressure-volume (PV) loops, including intrinsic parameters of myocardial function that are pre- and afterload independent. Combined with a clinically feasible experimental study protocol, these outcome measures provide researchers with essential information to determine whether novel therapeutic strategies could yield promising targets for future testing in clinical studies.

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“…In both studies, however, three‐dimensional echocardiography (3DE) was used as a reference standard. 3DE has been proven to be superior to the more conventional two‐dimensional echocardiography for volume measurements and is relatively inexpensive and useful for quick and noninvasive assessment of LV volumes (Dorosz et al 2012 ; Greupner et al 2012 ; Santos‐Gallego et al 2012 ; Kawamura et al 2013 ). However, 3DE has been observed to be less precise in estimating EF compared to cardiac magnetic resonance imaging (CMRI), the gold standard for volume determination (Dorosz et al 2012 ; Greupner et al 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Admittance-based pressure-volume loops versus gold standard cardiac magnetic resonance imaging in a porcine model of myocardial infarction

et al. 2014

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A novel admittance‐based pressure–volume system (AS) has recently been developed and introduced. Thus far, the new technique has been validated predominantly in small animals. In large animals it has only been compared to three‐dimensional echocardiography (3DE) where the AS showed to overestimate left ventricular (LV) volumes. To fully determine the accuracy of this device, we compared the AS with gold standard cardiac magnetic resonance imaging (CMRI) in a porcine model of chronic myocardial infarction (MI). Fourteen pigs were subjected to 90 min closed chest balloon occlusion of the left anterior descending artery. After 8 weeks of follow up, pigs were consecutively subjected to LV volume measurements by the AS, CMRI, and 3DE under general anesthesia. The AS overestimated end diastolic volume (EDV; +20.9 ± 30.6 mL, P = 0.024) and end systolic volume (ESV; +17.7 ± 29.4 mL, P = 0.042) but not ejection fraction (EF; +2.46 ± 6.16%, P = NS) compared to CMRI. Good correlations of EDV (R = 0.626, P = 0.017) and EF (R = 0.704, P = 0.005) between the AS and CMRI were observed. EF measured by the AS and 3DE also correlated significantly (R = 0.624, P = 0.030). After subjection of pigs to MI, the AS very moderately overestimates LV volumes and shows accurate measurements for EF compared to CMRI. This makes the AS a useful tool to determine cardiac function and dynamic changes in large animal models of cardiac disease.

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3d-Echocardiography Demonstrates Excellent Correlation With Cardiac Magnetic Resonance for Assessment of Left Ventricular Function and Volumes in a Model of Myocardial Infarction

Cited by 4 publications

References 0 publications

Correlation between Volumes Determined by Echocardiography and Cardiac MRI in Controls and Atrial Fibrillation Patients

Correlation between Volumes Determined by Echocardiography and Cardiac MRI in Controls and Atrial Fibrillation Patients

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Admittance-based pressure-volume loops versus gold standard cardiac magnetic resonance imaging in a porcine model of myocardial infarction

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