3D Finite Element Model of Meniscectomy: Changes in Joint Contact Behavior

Zielinska, Barbara; Donahue, Tammy L. Haut

doi:10.1115/1.2132370

Cited by 154 publications

(152 citation statements)

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“…It has been shown that under this condition, the biphasic response of cartilage can be negligible and the single-phase linear isotropic constitutive law be applicable [40,41]. Therefore, cartilage was modeled as a homogeneous, elastic, linearly isotropic material [1,2,[4][5][6][7]9,16,23,25,30,32,33,[35][36][37][38][39][42][43][44][45][46] with a modulus of 15 MPa [4,9,25,30,35,45] and a Poisson's ratio of 0.46 [31][32][33]47,48].…”

Section: Materials Propertiesmentioning

confidence: 99%

“…The femur and tibia were modeled as rigid structures, which greatly reduced the computational time and has been shown to have minimal effect on the model predictions [1,4,6,9,23,[29][30][31][32][33][34][35][36][37][38][39]. Articular cartilage is known to be an anisotropic, biphasic material with a time constant approaching 1500 s [40,41].…”

Section: Materials Propertiesmentioning

confidence: 99%

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Subject-Specific Finite Element Modeling of the Tibiofemoral Joint Based on CT, Magnetic Resonance Imaging and Dynamic Stereo-Radiography Data in Vivo

Carey

Zheng

Aiyangar

et al. 2014

Journal of Biomechanical Engineering

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In this paper, we present a new methodology for subject-specific finite element modeling of the tibiofemoral joint based on in vivo computed tomography (CT), magnetic resonance imaging (MRI), and dynamic stereo-radiography (DSX) data. We implemented and compared two techniques to incorporate in vivo skeletal kinematics as boundary conditions: one used MRI-measured tibiofemoral kinematics in a nonweight-bearing supine position and allowed five degrees of freedom (excluding flexion-extension) at the joint in response to an axially applied force; the other used DSX-measured tibiofemoral kinematics in a weight-bearing standing position and permitted only axial translation in response to the same force. Verification and comparison of the model predictions employed data from a meniscus transplantation study subject with a meniscectomized and an intact knee. The model-predicted cartilage-cartilage contact areas were examined against "benchmarks" from a novel in situ contact area analysis (ISCAA) in which the intersection volume between nondeformed femoral and tibial cartilage was characterized to determine the contact. The results showed that the DSX-based model predicted contact areas in close alignment with the benchmarks, and outperformed the MRI-based model: the contact centroid predicted by the former was on average 85% closer to the benchmark location. The DSX-based FE model predictions also indicated that the (lateral) meniscectomy increased the contact area in the lateral compartment and increased the maximum contact pressure and maximum compressive stress in both compartments. We discuss the importance of accurate, task-specific skeletal kinematics in subject-specific FE modeling, along with the effects of simplifying assumptions and limitations.

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Section: Materials Propertiesmentioning

confidence: 99%

Section: Materials Propertiesmentioning

confidence: 99%

Subject-Specific Finite Element Modeling of the Tibiofemoral Joint Based on CT, Magnetic Resonance Imaging and Dynamic Stereo-Radiography Data in Vivo

Carey

Zheng

Aiyangar

et al. 2014

Journal of Biomechanical Engineering

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“…Menisci were modeled as isotropic (Peña et al, 2005(Peña et al, , 2006(Peña et al, , 2008, transversely isotropic (Haut Donahue et al, 2002) or fiber-reinforced linearly elastic solid (Penrose et al, 2002;Shirazi et al, 2008). Example case studies are: knee joint under compression (Bendjaballah et al, 1995;Shirazi et al, 2008), knee joint in combined loading (Peña et al, 2006;Shirazi & Shirazi-Adl, 2009), effect of meniscectomies (Peña et al, 2005(Peña et al, , 2008Yang et al, 2009;Zielinska & Donahue, 2006) and effect of ligament reconstruction on the knee joint biomechanics (Shirazi & Shirazi-Adl, 2009;Suggs et al, 2003). Although fluid flow is believed to play a substantial role in the load response of the knee, little information is known about the fluid pressurization in cartilages and menisci in the real knee contact configuration.…”

Section: Anatomically Accurate Knee Modelingmentioning

confidence: 99%

Fluid Pressurization in Cartilages and Menisci in the Normal and Repaired Human Knees

Li¹,

Kazemi²

2012

Modeling and Simulation in Engineering

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“…Meniscectomy causes instability to the knee joint with an increased risk of OA [5]. Partial meniscectomy has been reported to increase the risk for the onset of OA by increasing stress and strain in the articular cartilage [6]. The external medial tibial cartilage is vulnerable to thinning once the meniscus extrudes and its surface is in direct, non-physiological, cartilage-cartilage contact with femur [7].…”

Section: Introductionmentioning

confidence: 99%

A Less Invasive Approach of Medial Meniscectomy in Rat: A Model to Target Early or Less Severe Human Osteoarthritis

Juneja¹,

Ventura²,

Jay³

et al. 2016

J Arthritis

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Objectives: The existing medial meniscectomy (MMx) procedure in rodents involves transection of MCL and wide opening of the knee capsule followed by meniscus transection that results into articular cartilage degeneration and causes significant changes in subchondral bone at specific post-MMx period. These animals serve as experimental osteoarthritis (OA) models.Structurally, knee is very complex. There may be a need to uncouple articular cartilage degenerative changes from subchondral bone degenerative changes in experimental OA models. Therapeutical drugs/agents, designed to treat articular cartilage degenerative changes of OA knee, may not be effective to treat subchondral bone degenerative changes or vice versa.The purpose of the study was to modify the existing MMx procedure to a less invasive procedure so that it causes only articular cartilage degenerative OA changes and no subchondral bone changes. This will serve as an early OA model to target degenerative changes in articular cartilage in human.Methods: Ten 8-9 weeks old male athymic nude rats underwent less invasive MMx on right knee; the left knee served as unoperated control. The surgery involved no transection of MCL and opening of knee capsule wide. The medial meniscus was pulled out from a slit made on the medial aspect of the knee capsule, and was transected. At 10 weeks post-MMx, animals were sacrificed and knees were assessed. Results:There was no significant alteration in bone strength parameters (BV/TV, Tb.Th, Tb.Sp, Tb.N, Tb.Pf, cortical wall thickness) in subchondral bone in the less invasive MMx knee as analyzed by μCT. X-ray radiography did not indicate the presence of any osteophyte at the knee margins. On the other hand, the less invasive MMx caused degenerative changes in articular cartilage as follows: fibrillation and thinning in the medial tibia; narrowing of medial knee joint; reduced proteoglycans shown by safranin-O staining; decreased metachromasia by PSR staining; alteration in collagen fibril thickness under cross-polarization light. Immunohistochemical expression was reduced (COL-II, aggrecan), increased (NITEGE, Col2-3/4m, COL-X, and MMP13) or imbalanced (lubricin) in articular cartilage thickness of less invasive MMx knee. Conclusion:The less invasive MMx procedure, in rat, can be a model for early or less severe human OA due to articular cartilage degenerative changes only and with no subchondral bone degenerative changes in the knee synovial joint. The therapeutical drugs/agents designed to repair articular cartilage may be suitable for this model and may lead to treatment of early or less severe human OA.Citation: Juneja SC, Ventura M, Jay GD, Veillette C (2016) A Less Invasive Approach of Medial Meniscectomy in Rat: A Model to Target Early or Less Severe Human Osteoarthritis. J Arthritis 5: 193. doi:10.4172/2167-7921.1000193 Page 2 of 17 In rat and mouse, MMx surgery is usually conducted first by transecting the medial collateral ligament (MCL) fully or partially followed by wide opening of the knee capsule, ...

show abstract

3D Finite Element Model of Meniscectomy: Changes in Joint Contact Behavior

Cited by 154 publications

References 33 publications

Subject-Specific Finite Element Modeling of the Tibiofemoral Joint Based on CT, Magnetic Resonance Imaging and Dynamic Stereo-Radiography Data in Vivo

Subject-Specific Finite Element Modeling of the Tibiofemoral Joint Based on CT, Magnetic Resonance Imaging and Dynamic Stereo-Radiography Data in Vivo

Fluid Pressurization in Cartilages and Menisci in the Normal and Repaired Human Knees

A Less Invasive Approach of Medial Meniscectomy in Rat: A Model to Target Early or Less Severe Human Osteoarthritis

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