Improving the accuracy of edge pixel classification is an important aspect of using convolutional neural networks (CNNs) to extract winter wheat spatial distribution information from remote sensing imagery. In this study, we established a method using prior knowledge obtained from statistical analysis to refine CNN classification results, named post-processing CNN (PP-CNN). First, we used an improved RefineNet model to roughly segment remote sensing imagery in order to obtain the initial winter wheat area and the category probability vector for each pixel. Second, we used manual labels as references and performed statistical analysis on the class probability vectors to determine the filtering conditions and select the pixels that required optimization. Third, based on the prior knowledge that winter wheat pixels were internally similar in color, texture, and other aspects, but different from other neighboring land-use types, the filtered pixels were post-processed to improve the classification accuracy. We used 63 Gaofen-2 images obtained from 2017 to 2019 of a representative Chinese winter wheat region (Feicheng, Shandong Province) to create the dataset and employed RefineNet and SegNet as standard CNN and conditional random field (CRF) as post-process methods, respectively, to conduct comparison experiments. PP-CNN’s accuracy (94.4%), precision (93.9%), and recall (94.4%) were clearly superior, demonstrating its advantages for the improved refinement of edge areas during image classification.