image segmentation using geometric deformable models and metaheuristics. Computerized Medical Imaging and Graphics, Elsevier, 2015, 43, pp.167-178. 10.1016/j.compmedimag.2013 Abstract This paper describes a hybrid level set approach for medical image segmentation. This new geometric deformable model combines region-and edge-based information with the prior shape knowledge introduced using deformable registration. Our proposal consists of two phases: training and test. The former implies the learning of the level set parameters by means of a Genetic Algorithm, while the latter is the proper segmentation, where another metaheuristic, in this case Scatter Search, derives the shape prior. In an experimental comparison, this approach has shown a better performance than a number of state-of-the-art methods when segmenting anatomical structures from different biomedical image modalities.