3D micromixers based on Koch fractal principle

Chen, Xueye; Zhang, Shuai

doi:10.1007/s00542-017-3637-9

Cited by 21 publications

(6 citation statements)

References 37 publications

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“…The use of this device is growing because it is widely used in various fields including microchemical analysis , chemical synthesis (Thiermann et al 2017), clinical diagnosis (Fatimah et al 2020), and others. The micromixer is one part of the LoC based on a mechanical micro-section that is used to mix liquid volumes on the microliter or nanoliter scale (Chen and Zhang 2018). This represents an important topic to study because the development characteristics of the micromixer chips are multi-function (Hama et al 2018), miniaturisation (Pawinanto et al 2020), portable (Rohman et al 2020), and small dimensions from millimetre to micrometre .…”

Section: Introductionmentioning

confidence: 99%

A Passive Micromixer with Koch Snowflakes Fractal Obstacle in Microchannel

2022

JAFM

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The passive micromixer is one of the essential devices that can be integrated into the Lab on Chip (LoC) system. Micromixer is needed to increase mixing efficiency. In this paper, two Koch fractal obstacle-based micromixer models of Secondary Snowflakes Fractal Micromixer (SSFM) and Tertiary Snowflakes Fractal Micromixer (TSFM) were designed. The effect of the Koch fractal resistance angles (15 o , 30 o , 45 o , 315 o , 330 o , 345 o ) and the influence of the inlet (T and T-vortex) were studied in this paper using COMSOL Multiphysics numerical simulations. The results showed that the TSFM structure with a 30 o angle on the T-vortex inlet is optimal. The deflection phenomena generated by the TSFM obstacle enhance the contact area between the two fluids and chaotic convection can be increased at Reynolds Number (Re) 0.05 and Re 100. This paper examines concentration curves along the channel ranging from 1 mol/L to 5 mol/L. This clearly shows that the fluid flow direction changes within the microchannel. This work provides a new design for the micromixer.

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Section: Introductionmentioning

confidence: 99%

A Passive Micromixer with Koch Snowflakes Fractal Obstacle in Microchannel

2022

JAFM

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“…The chaotic effect increases the effective contact surface area and overall contact time between the reactants, which results in an improved mixing efficiency compared to just a straight microchannel [9]. Examples of enhanced passive mixing strategies employed in micromixers include the use of intersecting channels [10][11][12][13][14][15], the addition of curvatures [16][17][18], and the inclusion of obstacles or barriers to the liquid flow [19][20][21][22][23]. For example, Solehati et al [24] conducted a numerical study comparing the mixing efficiencies of wavy and straight T-junction micromixers.…”

Section: Introductionmentioning

confidence: 99%

A Numerical Study of Sub-Millisecond Integrated Mix-and-Inject Microfluidic Devices for Sample Delivery at Synchrotron and XFELs

2021

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Microfluidic devices which integrate both rapid mixing and liquid jetting for sample delivery are an emerging solution for studying molecular dynamics via X-ray diffraction. Here we use finite element modelling to investigate the efficiency and time-resolution achievable using microfluidic mixers within the parameter range required for producing stable liquid jets. Three-dimensional simulations, validated by experimental data, are used to determine the velocity and concentration distribution within these devices. The results show that by adopting a serpentine geometry, it is possible to induce chaotic mixing, which effectively reduces the time required to achieve a homogeneous mixture for sample delivery. Further, we investigate the effect of flow rate and the mixer microchannel size on the mixing efficiency and minimum time required for complete mixing of the two solutions whilst maintaining a stable jet. In general, we find that the smaller the cross-sectional area of the mixer microchannel, the shorter the time needed to achieve homogeneous mixing for a given flow rate. The results of these simulations will form the basis for optimised designs enabling the study of molecular dynamics occurring on millisecond timescales using integrated mix-and-inject microfluidic devices.

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“…[5][6][7][8] Therefore, to improve the mixing efficiency of the uid in the micromixer, researchers usually change the geometry of the micromixer or add external conditions to improve the mixing efficiency of the working uid. [9][10][11] Generally, micromixers are divided into two types according to their working principles: passive and active. 12 The passive micromixer has the advantages of simple structure, low manufacturing difficulty and easy integration.…”

Section: Introductionmentioning

confidence: 99%