3D multicellular micropatterning biomaterials for hair regeneration and vascularization

Ma, Jingge; Chen, Qin; Wu, Jinfu; Zhuang, Hui; Du, Lin; Xu, Jie; Wu, Chengtie

doi:10.1039/d3mh00528c

Cited by 5 publications

(3 citation statements)

References 64 publications

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“…, vascular endothelial cells and dermal papilla cells, were distributed in the system, mimicking the structure of vessel networks and hair follicles in skin. 1424 The developed 3D multicellular micropattern could effectively induce hair follicle formation, hair regrowth, angiogenesis and skin regeneration.…”

Section: Biomedical Applications Of Silicon-containing Biomaterialsmentioning

confidence: 99%

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chen,

Zhang,

Duan

et al. 2024

Chem. Soc. Rev.

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Section: Biomedical Applications Of Silicon-containing Biomaterialsmentioning

confidence: 99%

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chen,

Zhang,

Duan

et al. 2024

Chem. Soc. Rev.

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“…Additionally, biomimetic engineering plays a promising role in tissue engineering, where scaffolds mimic tissue structures and/or cell–cell interactions. Biomimetic applications have been demonstrated to improve bone, cardiac, nerve, hair, and skin tissue regeneration, among others [ 102 , 103 , 104 , 105 ].…”

Section: Biomimetic Engineering Of Biomaterialsmentioning

confidence: 99%

Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

Berry,

Brenac,

Gonzalez

et al. 2024

IJMS

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Throughout history, natural products have played a significant role in wound healing. Fibroblasts, acting as primary cellular mediators in skin wound healing, exhibit behavioral responses to natural compounds that can enhance the wound healing process. Identifying bioactive natural compounds and understanding their impact on fibroblast behavior offers crucial translational opportunities in the realm of wound healing. Modern scientific techniques have enabled a detailed understanding of how naturally derived compounds modulate wound healing by influencing fibroblast behavior. Specific compounds known for their wound healing properties have been identified. Engineered biomimetic compounds replicating the natural wound microenvironment are designed to facilitate normal healing. Advanced delivery methods operating at micro- and nano-scales have been developed to effectively deliver these novel compounds through the stratum corneum. This review provides a comprehensive summary of the efficacy of natural compounds in influencing fibroblast behavior for promoting wound regeneration and repair. Additionally, it explores biomimetic engineering, where researchers draw inspiration from nature to create materials and devices mimicking physiological cues crucial for effective wound healing. The review concludes by describing novel delivery mechanisms aimed at enhancing the bioavailability of natural compounds. Innovative future strategies involve exploring fibroblast-influencing pathways, responsive biomaterials, smart dressings with real-time monitoring, and applications of stem cells. However, translating these findings to clinical settings faces challenges such as the limited validation of biomaterials in large animal models and logistical obstacles in industrial production. The integration of ancient remedies with modern approaches holds promise for achieving effective and scar-free wound healing.

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“…Novel technologies such as bio-3D printing and microneedles also have been used for tissue engineered HF regeneration studies. In vitro 3D printing can precisely introduce complex adnexal structures within biomaterial tissue engineering matrix, and arrange cells into a biomimetic micropattern that simulated the tissue structures of dermis and hair follicles [ 100 ]. Zheng et al developed an HF organoid-loaded methacrylated gelatin-cryomicroneedles which could easily delivery the HF organoids under the skin [ 101 ].…”

Section: Biomimetic Biomaterials For Skin Appendage Regenerationmentioning

confidence: 99%

Advances and applications of biomimetic biomaterials for endogenous skin regeneration

Wang,

Hong,

et al. 2024

Bioactive Materials

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3D multicellular micropatterning biomaterials for hair regeneration and vascularization

Abstract: Hair loss caused by the abnormal functions of hair follicles in skin seriously impacts the quality of individual life. The development of sophisticated skin tissue-engineered constructs is required to enable...

Cited by 5 publications

References 64 publications

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

Advances and applications of biomimetic biomaterials for endogenous skin regeneration

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