3D porous HA/TCP composite scaffolds for bone tissue engineering

Zerankeshi, Meysam Mohammadi; Mofakhami, Sohrab; Salahinejad, E.

doi:10.1016/j.ceramint.2022.05.103

Cited by 37 publications

(10 citation statements)

References 147 publications

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“…124 The scaffold microstructure and resulting degradation rate can be manipulated by using biphasic calcium phosphate scaffolds, such as HAP/TCP systems. 125,126…”

Section: Advanced Hap and Hap-hybrid Systemsmentioning

confidence: 99%

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Tackling current production of HAp and HAp-driven biomaterials

Veiga,

Madureira,

Costa

et al. 2023

Mater. Adv.

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“…124 The scaffold microstructure and resulting degradation rate can be manipulated by using biphasic calcium phosphate scaffolds, such as HAP/TCP systems. 125,126…”

Section: Advanced Hap and Hap-hybrid Systemsmentioning

confidence: 99%

“…124 The scaffold microstructure and resulting degradation rate can be manipulated by using biphasic calcium phosphate scaffolds, such as HAP/TCP systems. 125,126 The use of polymeric matrixes in combination or incorporated with CaP particles is another route proposed to combine CaP with growth factors (Fig. 4(B)).…”

Section: Advanced Hap and Hap-hybrid Systemsmentioning

confidence: 99%

Tackling current production of HAp and HAp-driven biomaterials

Veiga,

Madureira,

Costa

et al. 2023

Mater. Adv.

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“…There is normally a positive correlation between biocompatibility and mechanical strength or toughness to uphold mechanical support concerning healing and inhibiting a stress-shielding impact. Principally, the comparatively poor biocompatibility relates to low mechanical strength and toughness, which can result in critical limitations during tissue engineering. For instance, the biocompatibility of microfibrous structures reduces after the incorporation of synthetic polymers into a high-toughness hydrogel .…”

Section: Introductionmentioning

confidence: 99%

“…Hence, this evidence demonstrates serious issue in manufacturing fibrous hydrogels with a porous structure, improved toughness, high mechanical properties, and biocompatibility. Indeed, several extrinsic functionalizations on the scaffold structure were proposed to aid in improving their bioperformance, including encapsulation, biopolymeric additives, and dopants/coatings . This allows their appropriateness for tissue engineering, along with other biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Bioactive Gel-like Double Emulsion into a Biocompatible Hierarchical Macroporous Self-Lubricating Scaffold for 3D Cell Culture

Shahbazi,

Jäger,

Mohammadi

et al. 2023

ACS Appl. Mater. Interfaces

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The interconnected hierarchically porous structures are of key importance for potential applications as substrates for drug delivery, cell culture, and bioscaffolds, ensuring cell adhesion and sufficient diffusion of metabolites and nutrients. Here, encapsulation of a vitamin C-loaded gel-like double emulsion using a hydrophobic emulsifier and soy particles was performed to develop a bioactive bioink for 3D printing of highly porous scaffolds with enhanced cell biocompatibility. The produced double emulsions suggested a mechanical strength with the range of elastic moduli of soft tissues possessing a thixotropic feature and recoverable matrix. The outstanding flow behavior and viscoelasticity broaden the potential of gel-like double emulsion to engineer 3D scaffolds, in which 3D constructs showed a high level of porosity and excellent shape fidelity with antiwearing and self-lubricating properties. Investigation of cell viability and proliferation using fibroblasts (NIH-3T3) within vitamin C-loaded gel-like bioinks revealed that printed 3D scaffolds offered brilliant biocompatibility and cell adhesion. Compared to scaffolds without encapsulated vitamin C, 3D scaffolds containing vitamin C showed higher cell viability after 1 week of cell proliferation. This work represented a systematic investigation of hierarchical self-assembly in double emulsions and offered insights into mechanisms that control microstructure within supramolecular structures, which could be instructive for the design of advanced functional tissues.

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“…13,14 New bone can grow from the HA implant to the original bone by climbing along the implant surface or through the internal penetrating pores. 15,16…”

Section: Introductionmentioning

confidence: 99%