3D-printable self-healing and mechanically reinforced hydrogels with host–guest non-covalent interactions integrated into covalently linked networks

Wang, Zhifang; An, Geng; Zhu, Ye; Liu, Xuemin; Chen, Yunhua; Wu, Hongkai; Wang, Yingjun; Shi, Xuetao; Mao, Chuanbin

doi:10.1039/c8mh01208c

Cited by 179 publications

(109 citation statements)

References 63 publications

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“…The shape stability of the printed features could be significantly enhanced through a second step of covalent crosslinking. For example, through photoinitiated covalent crosslinking, [ 86,91,94,95,102–105 ] strong ionic interactions of alginate with calcium, [ 92,101,106 ] or horseradish peroxidase/hydrogen peroxide crosslinking (H 2 O 2 ). [ 95 ] Burdick and co‐workers reported that despite achieving 3D layer‐by‐layer grid structures using hydrogels crosslinked with only a supramolecular network, the filaments were still fused together when printing multilayers due to the dynamic nature of supramolecular interactions (Figure 3D).…”

Section: Materials Designs For 3d Printabilitymentioning

confidence: 99%

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Extrusion 3D Printing of Polymeric Materials with Advanced Properties

et al. 2020

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3D printing is a rapidly growing technology that has an enormous potential to impact a wide range of industries such as engineering, art, education, medicine, and aerospace. The flexibility in design provided by this technique offers many opportunities for manufacturing sophisticated 3D devices. The most widely utilized method is an extrusion‐based solid‐freeform fabrication approach, which is an extremely attractive additive manufacturing technology in both academic and industrial research communities. This method is versatile, with the ability to print a range of dimensions, multimaterial, and multifunctional 3D structures. It is also a very affordable technique in prototyping. However, the lack of variety in printable polymers with advanced material properties becomes the main bottleneck in further development of this technology. Herein, a comprehensive review is provided, focusing on material design strategies to achieve or enhance the 3D printability of a range of polymers including thermoplastics, thermosets, hydrogels, and other polymers by extrusion techniques. Moreover, diverse advanced properties exhibited by such printed polymers, such as mechanical strength, conductance, self‐healing, as well as other integrated properties are highlighted. Lastly, the stimuli responsiveness of the 3D printed polymeric materials including shape morphing, degradability, and color changing is also discussed.

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Section: Materials Designs For 3d Printabilitymentioning

confidence: 99%

“…Besides excellent mechanical properties and self‐healing, the biocompatibility of 3D printable polymers could be achieved through constructing the double network consisting of host–guest interaction and covalent bonds. [ 105 ]…”

Section: Retaining Materials Properties Of Printed Polymersmentioning

confidence: 99%

Extrusion 3D Printing of Polymeric Materials with Advanced Properties

et al. 2020

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“…Unfortunately, cartilage is an avascular and nervefree tissue, and its healing/self-regeneration upon damage remains a significant clinical challenge 3 . To date, various hydrogel systems, such as injectable hydrogels 4 and 3D printed cell-laden hydrogels 5 , have been deployed as bioscaffolds for articular cartilage tissue engineering 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Multifunctional load-bearing hybrid hydrogel with combined drug release and photothermal conversion functions

et al. 2020

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The inability of damaged load-bearing cartilage to regenerate and self-repair remains a long-standing challenge in clinical settings. In the past, the use of PVA hydrogels as cartilage replacements has been explored; however, both pristine and annealed PVA are not ideal for load-bearing cartilage applications, and new materials with improved properties are highly desirable. In this work, we developed a novel hybrid hydrogel system consisting of glycerolmodified PVA hydrogel reinforced by a 3D printed PCL-graphene composite scaffold. The composition of the hydrogel within the hybrid material was optimized to achieve high water retention and enhanced stiffness. The hybrid hydrogel formed by reinforcement with a 3D printed PCL-graphene scaffold with optimized architecture demonstrated desirable mechanical properties (stiffness, toughness, and tribological properties) matching those of natural loadbearing cartilage. Our novel hydrogel system has also been designed to provide drug release and on-demand photothermal conversion functions and at the same time offers excellent biocompatibility with low cell adhesion. These promising properties may allow our unique hybrid hydrogel system to be used for potential applications, such as load-bearing cartilage repair/replacement, as well as targeting certain challenging clinical conditions, such as the treatment of severe arthritis.

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“…Therefore, the low‐cost, green, and high‐efficiency fabrication of self‐healing materials should be developed in further research. 3D printing, as a promising manufacturing technology, which can be used to fabricate multiscale constructs via smart control systems and recently, the self‐healing biocompatible hydrogels fabricated by 3D printing have been reported . Compared with traditional hydrogels, the 3D‐printed hydrogel scaffolds exhibited special and homogeneous porous structures, therefore, in this case, the combination of 3D printed nanostructure and self‐healing will enhance the interfacial properties of materials.…”

Section: Discussionmentioning

confidence: 99%

Flourishing Self‐Healing Surface Materials: Recent Progresses and Challenges

Tie

Panhwar

Zhao

2020

Adv Materials Inter

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In the past few decades, the self‐healing surface materials with durable mechanical, functional, and structural properties have attracted enormous research interests, which exhibit great potential in energy conversion devices, sensors, electronic skins, superhydrophobic fabrics, medical/biological hydrogel, and a protective coating. Despite the remarkable progresses achieved in the self‐healing surface, the systematic and overall reviews that focus on self‐healing surface materials are still lacking and in urgent need. Herein, the recent advances in the development of self‐healing surface materials are summarized. The surface damage forms that composed of cracks, scratches, punctures, and surface wear, are systematically reviewed. The self‐healing mechanism and methods at interface are then introduced to briefly explain the basic design principle. The recent developments of functional surfaces including superhydrophobic, oleophobic, antifogging, anti‐icing, antibiofouling, and anticorrosion surfaces with self‐healing functions are further discussed. Finally, the contemporary challenges, and the future perspectives that motivate are proposed to create more innovative self‐healing materials for diverse fields.

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3D-printable self-healing and mechanically reinforced hydrogels with host–guest non-covalent interactions integrated into covalently linked networks

Abstract: Novel 3D-printable hydrogels with host–guest non-covalent interactions and covalently crosslinked networks show robust mechanical strength, self-healing performance and excellent biocompatibility.

Cited by 179 publications

References 63 publications

Extrusion 3D Printing of Polymeric Materials with Advanced Properties

Extrusion 3D Printing of Polymeric Materials with Advanced Properties

Multifunctional load-bearing hybrid hydrogel with combined drug release and photothermal conversion functions

Flourishing Self‐Healing Surface Materials: Recent Progresses and Challenges

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