3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients

Lei, Iek Man; Jiang, Chen; Lei, Chon Lok; Rijk, Simone R. de; Tam, Yu Chuen; Swords, Chloe; Sutcliffe, M.P.F.; Malliaras, George G.; Bance, Manohar; Huang, Yan Yan Shery

doi:10.1038/s41467-021-26491-6

Cited by 35 publications

(26 citation statements)

References 50 publications

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“…The C-M equation and the new inhomogeneity parameter can also be used to analyze the anti-corrosion performance, guide metal selection, assist corrosion management, estimate the economy loss and prevent the disaster caused by corrosion. With the development of biomaterials [ 48–53 ], the biodegradable type has been the front of medical devices [ 54–57 ], and some corrodible metals have been tried as the skeletal materials [ 58–60 ]. Even a metal-polymer composite stent has been into clinical research [ 61 , 62 ].…”

Section: Disscusionmentioning

confidence: 99%

Establishment of coverage-mass equation to quantify the corrosion inhomogeneity and examination of medium effects on iron corrosion

Ding

2023

Regenerative Biomaterials

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Metal corrosion is important in the fields of biomedicine as well as construction and transportation etc. While most corrosion occurs inhomogeneously, there is so far no satisfactory parameter to characterize corrosion inhomogeneity. Herein, we employ the Poisson raindrop question to model the corrosion process and derive an equation to relate corrosion coverage and corrosion mass. We also suggest corrosion mass at 50% coverage, termed as half-coverage mass Mcorro50%, as an inhomogeneity parameter to quantify corrosion inhomogeneity. The equation is confirmed and the half-coverage mass Mcorro50%, is justified in our experiments of iron corrosion in five aqueous media, normal saline (NS), phosphate buffered saline (PBS), Hank’s solution (HS), deionized water (DI), and artificial seawater (AS), where the former three ones are biomimetic and very important in studies of biomedical materials. The half-coverage mass Mcorro50%, is proved to be more comprehensive and mathematically convergent than the traditional pitting factor. Iron corrosion is detected using visual observation, scanning electron microscopy with a build-in energy dispersive spectrometer, inductive coupled plasma emission spectrometry, and electrochemical measurements. Both rates and inhomogeneity extents of iron corrosion are compared among the five aqueous media. The factors underlying the medium effects on corrosion rate and inhomogeneity are discussed and interpreted. Corrosion rates of iron in the five media differ about 7 folds, and half-coverage mass values differ about 300,000 folds. The fastest corrosion and the most significant inhomogeneity occur both in biomimetic media, but not the same one. The new equation and the new quantity are stimulating for dealing with a dynamic and stochastic process with inhomogeneity including but not limited to metal corrosion. The findings are meaningful for research and development of biomaterials.

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Section: Disscusionmentioning

confidence: 99%

Establishment of coverage-mass equation to quantify the corrosion inhomogeneity and examination of medium effects on iron corrosion

Ding

2023

Regenerative Biomaterials

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“…One interesting solution is that 3D printing can be used to fabricate models with an appropriate size of embedded pores filled with a conductive solution that would enable fine-tuning the electrical properties of the material [28,88,106].…”

Section: Physical Modelsmentioning

confidence: 99%

Models of Cochlea Used in Cochlear Implant Research: A Review

et al. 2023

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As the first clinically translated machine-neural interface, cochlear implants (CI) have demonstrated much success in providing hearing to those with severe to profound hearing loss. Despite their clinical effectiveness, key drawbacks such as hearing damage, partly from insertion forces that arise during implantation, and current spread, which limits focussing ability, prevent wider CI eligibility. In this review, we provide an overview of the anatomical and physical properties of the cochlea as a resource to aid the development of accurate models to improve future CI treatments. We highlight the advancements in the development of various physical, animal, tissue engineering, and computational models of the cochlea and the need for such models, challenges in their use, and a perspective on their future directions.

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“…Liquid directional transfer in the liquid environment is more complicated than in the atmospheric environment. Analyses, detections, processing, and preparations, such as sample DNA preparation, PCR reaction, liquid chromatography, electrophoresis detection, and embedded printing, are performed in a liquid environment. − Zhao et al prepared the adaptive organo-hydrogel by an in situ heterophase emulsion polymerization technique to achieve adaptable wettability transition in different liquid environments. Zhou et al presented a facile method to construct a biomimetic PVA hydrogel and PDMS gel surface for the unidirectional transport of liquids in under-liquid environments.…”

Section: Surface Structure Regulated Overflow In Microscalementioning

confidence: 99%

Overflow Control for Sustainable Development by Superwetting Surface with Biomimetic Structure

2022

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Liquid flowing around a solid edge, i.e., overflow, is a commonly observed flow behavior. Recent research into surface wetting properties and microstructure-controlled overflow behavior has attracted much attention. Achieving controllable macroscale liquid dynamics by manipulating the micro-nanoscale liquid overflow has stimulated diverse scientific interest and fostered widespread use in practical applications. In this review, we outline the evolution of overflow and present a critical survey of the mechanism of surface wetting properties and microstructure-controlled liquid overflow in multilength scales ranging from centimeter to micro and even nanoscale. We summarize the latest progress in utilizing the mechanisms to manipulate liquid overflow and achieve macroscale liquid dynamics and in emerging applications to manipulate overflow for sustainable development in various fields, along with challenges and perspectives.

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3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients

Cited by 35 publications

References 50 publications

Establishment of coverage-mass equation to quantify the corrosion inhomogeneity and examination of medium effects on iron corrosion

Establishment of coverage-mass equation to quantify the corrosion inhomogeneity and examination of medium effects on iron corrosion

Models of Cochlea Used in Cochlear Implant Research: A Review

Overflow Control for Sustainable Development by Superwetting Surface with Biomimetic Structure

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