3D Printed Drug Delivery Systems Based on Natural Products

Abstract

<jats:p>In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.</jats:p>

Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine

“…This is achieved through tuning the printing process parameters which include the tablet’s size and layer thickness to control dosage form and release. The use of 3D printing technology in the development of personalized medicine and producing individualized drug dosage forms in the pharmaceutical industry could be useful [ 8 ]. For example, the formulation of a multi-drug single and one daily dose tablet, with appropriate release profiles, provides an attractive alternative manufacturing method.…”

Advances and prospective applications of 3D food printing for health improvement and personalized nutrition

“…Scale bar: 20 mm (Karavasili et al, 2020). (c) Improvements in food aesthetic, sustainability, and nutrient content of 3D-printed foods (Rutzerveld, 2014;https://www.chloerutzerveld.com/edible-grow) different printer platforms (Aguilar-de-Leyva et al, 2020). Many studies are currently focusing on developing 3Dprinted objects to be used as pharmaceutical carriers; however, incorporating drugs into 3D-printed foods is now causing a revolution, and only limited information is available in the scientific literature.…”

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

“…Generally speaking, the list of biocompatible, cell-instructive materials that can be used in AM methodologies is limited [ 325 ]. It should also be noted that the typically high processing temperatures or laser-assisted polymerisation associated with several AM methodologies impair the encapsulation of thermolabile and laser-sensitive elements, such as proteins and cells, during the scaffold manufacturing process [ 348 , 349 ]. This is a very significant shortcoming of 3D printing techniques since it hinders the direct use of protein- or cell-loaded bioinks and forces the addition of such bioactive factors after each layer or whole scaffold fabrication.…”