3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property

Shao, Huifeng; Jing, Zhuoluo; Xia, Pengcheng; Zhang, Tao; Nian, Zhiheng; Liu, Wanshun; Zhu, Jiahua; Gong, Youping; Zhou, Rougang; He, Yong; Yao, Qingqiang

doi:10.1016/j.matdes.2022.111464

Cited by 16 publications

(12 citation statements)

References 52 publications

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“…The surface properties of 3D ceramic scaffolds also affect their physicochemical attributes and bioactivities. To enhance their osteoinductivity or mechanical strength, silicate ceramic scaffolds have been coated with diverse bioactive inorganic or organic materials, such as HA, [438][439][440] organic polymers, [441][442][443] and demineralized bone matrix. 444 Recently, Peng et al developed a selective surface modification strategy of coating inorganic or organic components on Mg-substituted wollastonite scaffolds and evaluated the corresponding effects on angiogenesis and osteogenesis.…”

Section: Design and Fabrication Of 3d Silicon-composed Biomaterialsmentioning

confidence: 99%

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chen,

Zhang,

Duan

et al. 2024

Chem. Soc. Rev.

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Section: Design and Fabrication Of 3d Silicon-composed Biomaterialsmentioning

confidence: 99%

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chen,

Zhang,

Duan

et al. 2024

Chem. Soc. Rev.

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“…By controlling printing parameters, such as pore size, porosity, distribution, and shape, the biomechanical properties and biocompatibility of the scaffold can be optimized. [266,267] Additionally, the development of new technologies involving antibacterial material modified implants is also crucial, including doping technology and surface modification technology. Doping technology has emerged as a vital method for preparing silverdoped biomaterials, and its potential applications are expected to increase with the continued development and exploration of new doping technologies.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Shao

Zhang

Gong

et al. 2023

Adv Healthcare Materials

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Bacterial infection caused by biomaterials is a very serious problem in the clinical treatment of implants. The emergence of antibiotic resistance has prompted other antibacterial agents to replace traditional antibiotics. Silver is rapidly developing as an antibacterial candidate material to inhibit bone infections due to its significant advantages such as high antibacterial timeliness, high antibacterial efficiency, and less susceptibility to bacterial resistance. However, silver has strong cytotoxicity, which can cause inflammatory reactions and oxidative stress, thereby destroying tissue regeneration, making the application of silver‐containing biomaterials extremely challenging. In this paper, the application of silver in biomaterials is reviewed, focusing on the following three issues: 1) how to ensure the excellent antibacterial properties of silver, and not easy to cause bacterial resistance; 2) how to choose the appropriate method to combine silver with biomaterials; 3) how to make silver‐containing biomaterials in hard tissue implants have further research. Following a brief introduction, the discussion focuses on the application of silver‐containing biomaterials, with an emphasis on the effects of silver on the physicochemical properties, structural properties, and biological properties of biomaterials. Finally, the review concludes with the authors’ perspectives on the challenges and future directions of silver in commercialization and in‐depth research.

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“…In addition, the thicker the nHA surface layer, the higher the mechanical strength and the apoptosis rate of OCs. 18 Akermanite (AKT, Ca 2 MgSi 2 O 7 ) is another bioceramic containing Ca, Mg, and Si, which is more controllable in terms of mechanical properties 73 and degradation rate. 74 Its first application was to synthesize pure polycrystalline AKT particles with a size of 5-40 μm by the sol-gel method.…”

Section: Primary 3d-printed Bioceramic Scaffoldsmentioning

confidence: 99%

“…In addition, the thicker the nHA surface layer, the higher the mechanical strength and the apoptosis rate of OCs. 18 …”

Section: Primary 3d-printed Bioceramic Scaffoldsmentioning

confidence: 99%

“… 9 – 12 Furthermore, numerous studies have shown that after being modified with several anti-tumor functional agents, bioceramic scaffolds like HA, 13 BG, 14 β-TCP, 15 and AKT 10 still show excellent osteogenesis ability. Nanosheets, 16 nanoparticles, 17 nano-coatings, 18 and even engineered microbes 19 can be added to these primary scaffolds to construct scaffolds with the primary osteogenic ability and new functions. These new functions include photothermal property, magnetothermal property, radical oxygen species generation, or anti-tumor gas generation for tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

Liu,

Qiang

et al. 2023

J Tissue Eng

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Osteosarcoma is the most prevalent bone malignant tumor in children and teenagers. The bone defect, recurrence, and metastasis after surgery severely affect the life quality of patients. Clinically, bone grafts are implanted. Primary bioceramic scaffolds show a monomodal osteogenesis function. With the advances in three-dimensional printing technology and materials science, while maintaining the osteogenesis ability, scaffolds become more patient-specific and obtain additional anti-tumor ability with functional agents being loaded. Anti-tumor therapies include photothermal, magnetothermal, old and novel chemo-, gas, and photodynamic therapy. These strategies kill tumors through novel mechanisms to treat refractory osteosarcoma due to drug resistance, and some have shown the potential to reverse drug resistance and inhibit metastasis. Therefore, multifunctional three-dimensional printed bioceramic scaffolds hold excellent promise for osteosarcoma treatments. To better understand, we review the background of osteosarcoma, primary 3D-printed bioceramic scaffolds, and different therapies and have a prospect for the future.

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3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property

Cited by 16 publications

References 52 publications

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

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