3D printed MCT oleogel as a co-delivery carrier for curcumin and resveratrol

Kavimughil, M.; Leena, M. Maria; Moses, J.A.; Anandharamakrishnan, C.

doi:10.1016/j.biomaterials.2022.121616

Cited by 61 publications

(18 citation statements)

References 93 publications

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“…A 3D printed medium-chain triglycerides oleogel used for the delivery of curcumin and resveratrol was developed recently which helps in the personalized delivery of drugs according to the need of patients. 30 A similar study was done on curcumin release by Palla et al in which curcumin was loaded within stable nanoemulsions made from monoglyceride OGs. 31 The preparation of OGs with single or multiple oleogelators, as well as their uses in providing nutrients or substituting solid fats with OGs, are discussed in a recent review.…”

Section: Introductionmentioning

confidence: 85%

“…The curcumin release study was conducted for 3 h. The rotation of the basket was fixed at a speed of 100 rpm. Then, at a specified time period (5,15,30,45,60,90,120,150, and 180 min), 5 mL of the dissolution media was withdrawn and the same volume was replaced with PBS. The samples were analyzed for curcumin content at the wavelength of 430 nm in a UV−visible spectrometer (UV-1900i, Shimadzu, Japan).…”

Section: ■ Introductionmentioning

confidence: 99%

“…Up to 67.66% of enhancement of bioaccessibility of curcumin was confirmed through in vitro analysis. A 3D printed medium-chain triglycerides oleogel used for the delivery of curcumin and resveratrol was developed recently which helps in the personalized delivery of drugs according to the need of patients . A similar study was done on curcumin release by Palla et al in which curcumin was loaded within stable nanoemulsions made from monoglyceride OGs .…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin

et al. 2022

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Oleogels (OGs) have gained a lot of interest as a delivery system for a variety of pharmaceuticals. The current study explains the development of jasmine floral wax (JFW) and wheat germ oil (WGO)-based OGs for oral drug (curcumin) delivery application. The OGs were made by dissolving JFW in WGO at 70 °C and cooling it to room temperature (25 °C). The critical gelation concentration of JFW that induces the gelation of WGO was found to be 10% (w/w). The OGs were characterized using various techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), microscopic analysis, and mechanical test. XRD data indicated that JFW influences the crystallinity of the OGs. Among the prepared OGs, OG 17.5 showed higher crystallization in the series. Optical microscopic studies demonstrated the formation of fiber structures due to the entanglement of crystals whereas, polarized light micrographs suggested the formation of spherulites or clustered crystallite structures. The mechanical properties of the OGs increased linearly with the increase in the JFW concentration. Curcumin-loaded OGs were examined for their controlled release applications. In summary, the developed OGs were found to have the necessary features for modulating the oral delivery of curcumin.

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Section: Introductionmentioning

confidence: 85%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin

et al. 2022

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“…With the increasing amount of research on curcumin, it has been found that curcumin has a wide range of pharmacological activities, such as antitumor, anti-inflammatory, antioxidant, antiviral, and anti-infection activities. 59 , 60 Curcumin exerts excellent antitumor effects by inhibiting proliferation, inducing apoptosis, and reversing MDR. 61 , 62 Curcumin can inhibit CSCs in numerous types of cancers, such as glioma and breast, colorectal, pancreatic, brain, and esophageal cancers.…”

Section: Npns Targeting Cscsmentioning

confidence: 99%

Natural Products-Based Nanoformulations: A New Approach Targeting CSCs to Cancer Therapy

Liao¹,

Li²,

Wang

et al. 2022

IJN

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Cancer stem cells (CSCs) lead to the occurrence and progression of cancer due to their strong tumorigenic, self-renewal, and multidirectional differentiation abilities. Existing cancer treatment methods cannot effectively kill or inhibit CSCs but instead enrich them and produce stronger proliferation, invasion, and metastasis capabilities, resulting in cancer recurrence and treatment resistance, which has become a difficult problem in clinical treatment. Therefore, targeting CSCs may be the most promising approach for comprehensive cancer therapy in the future. A variety of natural products (NP) have significant antitumor effects and have been identified to target and inhibit CSCs. However, pharmacokinetic defects and off-target effects have greatly hindered their clinical translation. NP-based nanoformulations (NPNs) have tremendous potential to overcome the disadvantages of NP against CSCs through site-specific delivery and by improving their pharmacokinetic parameters. In this review, we summarize the recent progress of NPNs targeting CSCs in cancer therapy, looking forward to transforming preclinical research results into clinical applications and bringing new prospects for cancer treatment.

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“…12 Kavimughil et al designed an emulsion-templated mediumchain triglyceride OG for curcumin delivery. 30 Another report by Liu and co-workers explained curcumin delivery by ethyl cellulose oleogels. 31 Li et al synthesized OGs by β-sitosterol and lecithin for curcumin delivery.…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of Cholesterol on Oral Delivery of Curcumin Using Oleogels Containing Wheat Germ Oil and Rose Floral Wax

Das,

Sanakal,

Sahu

et al. 2023

Crystal Growth & Design

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3D printed MCT oleogel as a co-delivery carrier for curcumin and resveratrol

Cited by 61 publications

References 93 publications

Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin

Preparation and Characterization of Novel Oleogels Using Jasmine Floral Wax and Wheat Germ Oil for Oral Delivery of Curcumin

Natural Products-Based Nanoformulations: A New Approach Targeting CSCs to Cancer Therapy

Effect of Cholesterol on Oral Delivery of Curcumin Using Oleogels Containing Wheat Germ Oil and Rose Floral Wax

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