3D printed orodispersible films with Aripiprazole

Jamróz, Witold; Kurek, Mateusz; Łyszczarz, Ewelina; Szafraniec, Joanna; Knapik-Kowalczuk, Justyna; Syrek, Karolina; Paluch, Marian; Jachowicz, Renata

doi:10.1016/j.ijpharm.2017.05.052

Cited by 205 publications

(111 citation statements)

References 23 publications

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“…Jamroz et al, prepared aripiprazole-loaded orodispersible film by using FDM-type 3D printer. 33) The 3D printing which is additive manufacturing process can produce the pore (about 650 × 300 µm) in the film structure, and the drug dissolution from film was increased compared with the film prepared by conventional casting method due to the increase of surface area. If we produced the film with the pore and lattice by using semi-solid extrusion type 3D printer, it could change the drug dissolution.…”

Section: Resultsmentioning

confidence: 99%

“…25) The properties of HPMC-based muco-adhesive films prepared by traditional casting methods have been reported, 26,27) and the preparation of oral films with different doses and shapes is important for personalized dosing and therapy. Film formulations have been prepared using inkjet-type and flexographic-type 2D printers [28][29][30] and a FDM-type 3D printer, 25,[31][32][33] whereas to our knowledge there have been no reports describing the preparation of drug-loaded oral muco-adhesive film formulations using a 3D bioprinter. Here we characterized printer-inks (HPMC-based hydrogels containing a drug) and the resulting films (dried 3D-printed films).…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations

Tagami

Yoshimura

Goto

et al. 2019

Biological & Pharmaceutical Bulletin

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Pharmaceutical applications of three dimensional (3D) printing technology are increasing following the approval of 3D-printed tablets by the U.S. Food and Drug Administration. Semi-solid extrusion-type 3D printers are used to 3D print hydrogel-and paste-based materials. We previously developed tablet formulations for semi-solid extrusion-type 3D bioprinters. In the present study, we extended our study to the preparation of muco-adhesive oral film formulations to 3D bioprint mouth ulcer pharmaceuticals. We focused on hydroxypropyl methylcellulose (HPMC)-based catechin (model drug)-loaded hydrogel formulations and found that the viscosity of a hydrogel formulation is dependent on the HPMC concentration, and that viscosity is important for facile 3D printing. HPMC-based films were prepared using two different drying methods (air drying and freeze drying). The films exhibited different drug dissolution profiles, and increasing the amount of HPMC in the film delayed drug dissolution. The fabrication of HPMC-based catechin-loaded films with different shapes provides a model of individualized, on-demand pharmaceuticals. Our results support the flexible application of 3D bioprinters (semi-solid extrusion-type 3D printers) for preparing film formulations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations

Tagami

Yoshimura

Goto

et al. 2019

Biological & Pharmaceutical Bulletin

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show abstract

“…Druk 3D, określany mianem technologii addytywnej, w odróżnieniu od "płaskiego" druku dwuwymiarowego obejmuje procesy związane z tworzeniem obiektów przestrzennych. Pierwszy patent na drukarkę 3D, którego autorem był Charles Hull, został przyznany w 1986 r. [21]. Pojęcie druku przestrzennego obejmuje wiele rodzajów metod wytwarzania obiektów różniących się między sobą materiałem, z którego powstaje wydruk, dokładnością odwzorowania projektu lub sposobem nakładania warstw (rycina 4).…”

Section: Druk 3dunclassified

Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy

Pyteraf¹,

Jamróz²,

Jachowicz³

2019

Farm Pol.

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Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy • The possibility of preparing drugs based on two-and three-dimensional printing technologies have recently been explored in the pharmaceutical field. Possibility of implementation of printing techniques in the preparation of compounded drugs, especially in a hospital pharmacy, was the object of this review. Printing technologies allow production of complex drug products in a single process. Therefore, this technology can become an innovative method preparation of compounded drugs adapted to patients with special therapeutic needs.

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“…Hot-melt extrusion has also been used to formulate solid filaments used in fused deposition modeling (FDM) 3D printers to produce ODFs [19]. Hot-melt ram extrusion 3D printing, which combines extrusion and printing, has also been explored to produce ODFs [20].…”

Section: Introductionmentioning

confidence: 99%

Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs

et al. 2020

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Stencil printing is a commonly used printing method, but it has not previously been used for production of pharmaceuticals. The aim of this study was to explore whether stencil printing of drug containing polymer inks could be used to manufacture flexible dosage forms with acceptable mass and content uniformity. Formulation development was supported by physicochemical characterization of the inks and final dosage forms. The printing of haloperidol (HAL) discs was performed using a prototype stencil printer. Ink development comprised of investigations of ink rheology in combination with printability assessment. The results show that stencil printing can be used to manufacture HAL doses in the therapeutic treatment range for 6–17 year-old children. The therapeutic HAL dose was achieved for the discs consisting of 16% of hydroxypropyl methylcellulose (HPMC) and 1% of lactic acid (LA). The formulation pH remained above pH 4 and the results imply that the drug was amorphous. Linear dose escalation was achieved by an increase in aperture area of the print pattern, while keeping the stencil thickness fixed. Disintegration times of the orodispersible discs printed with 250 and 500 µm thick stencils were below 30 s. In conclusion, stencil printing shows potential as a manufacturing method of pharmaceuticals.

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3D printed orodispersible films with Aripiprazole

Cited by 205 publications

References 23 publications

Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations

Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations

Printing technologies in pharmaceutical compounding as a new perspective for hospital pharmacy

Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs

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