3D printed polypyrrole scaffolds for pH-dependent drug delivery for bone regeneration

Lawrence, Matthew T.; Séguin, Cheryle A.; Price, Aaron D.

doi:10.1117/12.2583290

Cited by 5 publications

(3 citation statements)

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“…Vat-based 3D printing has also been used to fabricate other triggered drug delivery devices. In one example, an implantable bone scaffold with triggerable drug release for bone regeneration was fabricated through vat-based 3D printing [53]. The 3D printed bone scaffold contains nanoparticles which were loaded with drugs which aids in bone regrowth.…”

Section: Vat-based 3dpmentioning

confidence: 99%

3D Printing in Triggered Drug Delivery Devices: A Review

Cheung

Lee

et al. 2022

Biomedical Materials & Devices

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Triggered drug delivery devices use external stimulus to trigger the release of the drugs from the device. By controlling the exposure of the stimuli, it would allow for the control over the timing, duration and amount of drug being released from the device, improving drug efficacy. 3D printing uses on-demand deposition and crosslinking of materials to fabricate a product, increasing the customisability of the design and internal structure. By using 3D printing to fabricate triggered drug delivery devices, certain advantages such as complex geometries, gradient compositions, multi-material structures and embedded components can be conferred to the printed devices. In this review paper, triggered drug delivery devices which are fabricated using 3D printing techniques such as vat photopolymerisation and material extrusion are discussed. The advancement in certain areas of 3D printing, such as in multi-material 3D printing and hybrid additive manufacturing, which presents tremendous opportunities for fabricating future triggered drug delivery devices will also be reviewed.

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Section: Vat-based 3dpmentioning

confidence: 99%

3D Printing in Triggered Drug Delivery Devices: A Review

Cheung

Lee

et al. 2022

Biomedical Materials & Devices

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“…The sensors can detect these physiological changes and control the drug release through a microchip [ 11 ] . “Smart” materials can also be used to detect changes in physiological conditions and trigger drug release [ 12 ] . For the “active” smart drug delivery devices, the drug release can be triggered and controlled in a selfregulated, closed loop system.…”

Section: Introductionmentioning

confidence: 99%

3D printing and 3D-printed electronics: Applications and future trends in smart drug delivery devices

Cheung¹,

Goh²,

Priyadarshini³

et al. 2024

IJB

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Drug delivery devices which can control the release of drugs on demand allow for improved treatment to a patient. These smart drug delivery devices allow for the release of drugs to be turned on and off as needed, thereby increasing the control over the drug concentration within the patient. The addition of electronics to the smart drug delivery devices increases the functionality and applications of these devices. Through the use of 3D printing and 3D-printed electronics, the customizability and functions of such devices can also be greatly increased. With the development in such technologies, the applications of the devices will be improved. In this review paper, the application of 3D-printed electronics and 3D printing in smart drug delivery devices with electronics as well as the future trends of such applications are covered.

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“…Some studies already report that carefully designed 3D structures show better performance in batteries and supercapacitors 9,10 . In addition, some studies have incorporated conductive polymers in the 3D printing process, enabling applications in gas sensing 11,12 and also in the field of biomedical applications for bone regeneration and drug transport throughout the body [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Substrate Coating Produced via Additive Manufacturing with Conducting Polymers: Assessment in The Development of Electrodes

et al. 2023

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The production of conductive and organic devices from a 3D printer represents a promising strategy for several areas. In particular, the synthesis of polypyrrole-coated acrylonitrile butadiene styrene (ABS) composites can be considered an important step to produce conductive supports for 3D printing. Herein, it is reported the production of ABS samples through the additive manufacturing process (3D printing) accordingly to the Fused Deposition Modeling (FDM) method. The hydrophilic behavior was controlled by the surface treatment using air plasma for the following step of coating with polypyrrole (PPy) via an in situ polymerization, using two different oxidants: ferric chloride (FeCl 3 .6H 2 O) and ammonium persulfate (APS). The chemical, optical, surface, and electrical properties of these materials were characterized through Fourier Transform infrared spectroscopy (FTIR), contact angle measurements, cyclic voltammetry, Scanning Electron Microscopy (SEM), 4-probe electrical measurement, and mechanical tensile testing. The ABS/PPy (FeCl 3 ) composite exhibited a low electrical contact resistance and better performance for applications that require electrodes with a good conductance level.

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3D printed polypyrrole scaffolds for pH-dependent drug delivery for bone regeneration

Cited by 5 publications

References 0 publications

3D Printing in Triggered Drug Delivery Devices: A Review

3D Printing in Triggered Drug Delivery Devices: A Review

3D printing and 3D-printed electronics: Applications and future trends in smart drug delivery devices

Substrate Coating Produced via Additive Manufacturing with Conducting Polymers: Assessment in The Development of Electrodes

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