3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy

Liu, Yaqin; Li, Tao; Ma, Haitao; Zhai, Dong; Deng, Chengbin; Wang, Jinwu; Zhuo, Shangjun; Chang, Jiang; Wu, Chengtie

doi:10.1016/j.actbio.2018.04.014

Cited by 133 publications

(83 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacteria can easily adhere to the implant surface and subsequently form a biofilm (Costerton, Stewart, & Greenberg, 1999; Jin et al, 2014). Meanwhile, residual osteosarcoma cells around Ti implants could induce tumor recurrence and affect the osteogenic ability in early postoperative of osteosarcoma resection (Liu et al, 2018; Zhang, Shen, Ma, Peng, & Cai, 2019).…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Yang

Tao

Gong

et al. 2020

J Biomedical Materials Res

View full text Add to dashboard Cite

After bone tumor resection, the large bony deficits are commonly reconstructed with Ti‐based metallic endoprosthesis, which provide immediate stable fixation and allow early ambulation and weight bearing. However, when used in osteosarcoma resection, Ti implant‐relative infection and tumor recurrence were recognized as the two critical factors for implantation failure. Hence, in this work, a novel zinc oxide nanoparticle decorating with naringin was prepared and immobilized onto Ti substrate. The drugs delivery profiles proved that in the bacterial infection and Warburg effect of osteosarcoma‐induced acidic condition, naringin and Zn2+ can be released easily from the functional Ti substrate. The anti‐osteosarcoma and antibacterial assay showed the delivered naringin and Zn2+ can induce a remarkable increase of oxidative stress in bacteria (Escherichia coli and Staphylococcus aureus) and osteosarcoma (Saos‐2 cells) by producing reactive oxygen species (ROS). Accumulation of ROS results in damage of bacterial biofilm and bacterial membrane, leading to the leakage of bacterial RNA and DNA. Meanwhile, the increase of ROS induces osteosarcoma cell apoptosis by activating ROS/extracellular signal‐regulated kinase signaling pathway. Furthermore, in vitro cellular experiments, including cell viability, alkaline phosphatase activity, collagen secretion, extracellular matrix mineralization level, indicated that the functional Ti substrate exhibited great potential for osteoblasts proliferation and differentiation. Hence, this study provides a simple and promising strategy of developing multifunctional Ti‐based implants for the reconstruction of large bony after osteosarcoma resection.

show abstract

Section: Introductionmentioning

confidence: 99%

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Yang

Tao

Gong

et al. 2020

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Liu et al [97] recently reported the laser-induced photothermal properties of Cu-, Fe-, Mn-and Co-doped 3D-printed bioactive scaffolds based on sol-gel glass-ceramics for application in cancer treatment ( Figure 10). After being implanted in rabbits, the materials were capable of killing tumor cells due to thermal effect, and displayed excellent bone-forming activity by stimulating the osteogenic differentiation of bone-forming cells.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

“…Different colors were imparted to scaffolds by different dopants. Pictures reproduced from Liu et al [97] with permission. Figure 10.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

3D Printing of Hierarchical Scaffolds Based on Mesoporous Bioactive Glasses (MBGs)—Fundamentals and Applications

Baino

Fiume

2020

Materials

View full text Add to dashboard Cite

The advent of mesoporous bioactive glasses (MBGs) in applied bio-sciences led to the birth of a new class of nanostructured materials combining triple functionality, that is, bone-bonding capability, drug delivery and therapeutic ion release. However, the development of hierarchical three-dimensional (3D) scaffolds based on MBGs may be difficult due to some inherent drawbacks of MBGs (e.g., high brittleness) and technological challenges related to their fabrication in a multiscale porous form. For example, MBG-based scaffolds produced by conventional porogen-assisted methods exhibit a very low mechanical strength, making them unsuitable for clinical applications. The application of additive manufacturing techniques significantly improved the processing of these materials, making it easier preserving the textural and functional properties of MBGs and allowing stronger scaffolds to be produced. This review provides an overview of the major aspects relevant to 3D printing of MBGs, including technological issues and potential applications of final products in medicine.

show abstract

“…The high temperature generated by these scaffolds effectively killed tumor cells in vitro and significantly inhibited tumor growth in vivo . Furthermore, the bioactive elements doped scaffolds significantly promoted osteogenic differentiation of bone-forming cells ( Liu et al, 2018 ). The simultaneous ability of tumor therapy and bone regeneration has been also explored in other studies of the same group in 2016 and 2018, where the authors proposed a bifunctional graphene oxide (GO)-modified β-tricalcium phosphate (GO-TCP) composite scaffold and BG-CFS scaffolds via in situ growing CuFeSe2 (CFS) nanocrystals on the strut surface of BG material, combining a high photothermal effect with significantly improved bone-forming ability ( Ma et al, 2016 ; Dang et al, 2018 ).…”

Section: Biomaterials For Bone Tissue Applicationsmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.

show abstract

3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy

Cited by 133 publications

References 61 publications

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

Functionalization of Ti substrate with pH‐responsive naringin‐ZnO nanoparticles for the reconstruction of large bony after osteosarcoma resection

3D Printing of Hierarchical Scaffolds Based on Mesoporous Bioactive Glasses (MBGs)—Fundamentals and Applications

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Contact Info

Product

Resources

About