3D printing and modeling of congenital heart defects: A technical review

Townsend, Kevin; Pietila, Todd

doi:10.1002/bdr2.1342

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…Digital modeling and simulation techniques are crucial tools for accurately reflecting and modeling a patient's condition. For instance, anatomical models of the body and internal organs, created using 3D modeling tools, such as Mimics, Simpleware, and 3dSlicer ( 14 ), are invaluable for clinicians making diagnoses. Physical models, such as biomechanical models for blood vessels, muscles, and bones, provide doctors with the physical mechanisms needed to calculate and estimate full-cycle and full-field dynamic simulations.…”

Section: The Key Techniques With Regard To Medigit In Dm Managementmentioning

confidence: 99%

The potential of the Medical Digital Twin in diabetes management: a review

Chu

Tang

et al. 2023

Front. Med.

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Diabetes is a chronic prevalent disease that must be managed to improve the patient's quality of life. However, the limited healthcare management resources compared to the large diabetes mellitus (DM) population are an obstacle that needs modern information technology to improve. Digital twin (DT) is a relatively new approach that has emerged as a viable tool in several sectors of healthcare, and there have been some publications on DT in disease management. The systematic summary of the use of DTs and its potential applications in DM is less reported. In this review, we summarized the key techniques of DTs, proposed the potentials of DTs in DM management from different aspects, and discussed the concerns of this novel technique in DM management.

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Section: The Key Techniques With Regard To Medigit In Dm Managementmentioning

confidence: 99%

The potential of the Medical Digital Twin in diabetes management: a review

Chu

Tang

et al. 2023

Front. Med.

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“…The refined STL files are loaded into a 3D printer, then printing is started with appropriately selected materials. A variety of 3D printing technologies are available in cardiovascular medicine, including fused deposition modeling, selective laser sintering, stereolithography, material jetting, and injection molding; the details have been already described elsewhere (4,(38)(39)(40). A wide range of printing materials may be selected, including plastic (resin), silicone, nylon, and metal, as needed, and are primarily divided into rigid vs. soft rubber-like materials, opaque vs. transparent, and single-color vs. multi-color (4,(38)(39)(40)(41)(42)(43).…”

Section: Three-dimensional Printing Techniquesmentioning

confidence: 99%

Advanced Medical Use of Three-Dimensional Imaging in Congenital Heart Disease: Augmented Reality, Mixed Reality, Virtual Reality, and Three-Dimensional Printing

2020

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Recently improved three-dimensional (3D) cardiac imaging technologies are triggering the medical use of advanced visualization techniques including augmented reality, mixed reality, virtual reality, and 3D printing. The driving factor is the vast number of 3D cardiac images, acquired from patients with congenital heart disease (CHD), serving as a source of data for these new visualization techniques. Non-invasive visualization of accurate patient-specific cardiovascular anatomy is essential for the diagnosis and treatment of CHD, not only for accessing morphological complexity but also due to the difficulty deciding among the available treatment

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“…Additive manufacturing is increasingly utilized in cardiovascular medicine [15]. However, it mainly focuses on processing artificial models for planning of operative and interventional procedures [16][17][18]. In contrast, 3D-bioprinting processes biocompatible and living scaffolds that may outreach conventional 2D as well as 3D cell culture [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

3D-bioprinting of aortic valve interstitial cells: impact of hydrogel and printing parameters on cell viability

et al. 2022

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Background: Calcific aortic valve disease (CAVD) is a frequent cardiac pathology in the aging society. Although valvular interstitial cells (VIC) seem to play a crucial role, mechanisms of CAVD are not fully understood. Development of tissue-engineered cellular models by 3D-bioprinting may help to further investigate underlying mechanisms of CAVD. Methods: VIC were isolated from ovine aortic valves and cultured in Dulbecco’s Modified Eagle’s Medium (DMEM). VIC of passages six to ten were dissolved in a hydrogel consisting of 2% alginate and 8% gelatin with a concentration of 2x106 VIC/ml. Cell-free and VIC-laden hydrogels were printed with an extrusion-based 3D-bioprinter (3D-Bioplotter® Developer Series, EnvisionTec, Gladbeck, Germany), cross-linked and incubated for up to 28 days. Accuracy and durability of scaffolds was examined by microscopy and cell viability was tested by cell counting kit-8 assay and live/dead staining. Results: 3D-bioprinting of scaffolds was most accurate with a printing pressure of P<400 hPa, nozzle speed of v<20 mm/s, hydrogel temperature of TH=37 °C and platform temperature of TP=5 °C in a 90° parallel line as well as in a honeycomb pattern. Dissolving the hydrogel components in DMEM increased VIC viability on day 21 by 2.5-fold compared to regular 0.5% saline-based hydrogels (p<0.01). Examination at day 7 revealed dividing and proliferating cells. After 21 days the entire printed scaffolds were filled with proliferating cells. Live/dead cell viability/cytotoxicity staining confirmed beneficial effects of DMEM-based cell-laden VIC hydrogel scaffolds even 28 days after printing. Conclusions: By using low pressure printing methods, we were able to successfully culture cell-laden 3D-bioprinted VIC scaffolds for up to 28 days. Using DMEM-based hydrogels can significantly improve the long-term cell viability and overcome printing-related cell damage. Therefore, future applications 3D-bioprinting of VIC might enable the development of novel tissue engineered cellular 3D-models to examine mechanisms involved in initiation and progression of CAVD.

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3D printing and modeling of congenital heart defects: A technical review

Cited by 11 publications

References 5 publications

The potential of the Medical Digital Twin in diabetes management: a review

The potential of the Medical Digital Twin in diabetes management: a review

Advanced Medical Use of Three-Dimensional Imaging in Congenital Heart Disease: Augmented Reality, Mixed Reality, Virtual Reality, and Three-Dimensional Printing

3D-bioprinting of aortic valve interstitial cells: impact of hydrogel and printing parameters on cell viability

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