3D Printing and the Cystic Fibrosis Lung

Mirza, Alicia A.; Robinson, Terry E.; Gifford, Kyle; Guo, Haiwei

doi:10.1016/j.jcf.2018.09.004

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…The relatively recent advent of medical 3D printing has opened a new avenue for the accurate production of models of the human body for medical education [11,12]. In the context of breast imaging, several papers have explored the benefit of 3D printed phantoms for image quality analysis, surgical planning, and implantable bioprinted breast scaffolds [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Imaging properties of 3D printed breast phantoms for lesion localization and Core needle biopsy training

et al. 2020

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Background: Breast cancer is the most commonly diagnosed malignancy in females and frequently requires core needle biopsy (CNB) to guide management. Adequate training resources for CNB suffer tremendous limitations in reusability, accurate simulation of breast tissue, and cost. The relatively recent advent of 3D printing offers an alternative for the development of breast phantoms for training purposes. However, the feasibility of this technology for the purpose of ultrasound (US) guided breast intervention has not been thoroughly studied. Methods: We designed three breast phantom models that were printed in multiple resins available through Stratasys, including VeroClear, TangoPlus and Tissue Matrix. We also constructed several traditional breast phantoms using chicken breast and Knox gelatin for comparison. These phantoms were compared side-by-side for ultrasound penetrance, simulation of breast tissue integrity, anatomic accuracy, reusability, and cost. Results: 3D printed breast phantoms were more anatomically accurate models than traditional breast phantoms. The chicken breast phantom provided acceptable US beam penetration and material hardness for simulation of human breast tissue integrity. Sonographic image quality of the chicken breast phantom was the most accurate overall. The gelatin-based phantom also had acceptable US beam penetration and image quality; however, this material was too soft and poorly simulated breast tissue integrity. 3D printed phantoms were not visible under US. Conclusions: There is a large unmet need for a printable material that is truly compatible with multimodality imaging for breast and other soft tissue intervention. Further research is warranted to create a realistic, reusable and affordable material to 3D print phantoms for US-guided intervention training.

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Section: Introductionmentioning

confidence: 99%

Imaging properties of 3D printed breast phantoms for lesion localization and Core needle biopsy training

et al. 2020

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“…Biofabrication technologies can be used in clinical care as they are able to print biocompatible polymers, ceramics, and metals, as well as extracellular matrix and cells towards providing customised implants within the operating theatre. As a case study, Royal Perth Hospital expanded a popular rapid prototyping service into a medical engineering and physics unit, providing a 5-employee referral service for local and remote clinicians interested in bespoke anatomical models and surgical guides [6], as well as acellular implants [7] and cellularised grafts [8].In this issue of Journal of Cystic Fibrosis, Mirza et al have published a 3D printed CF lung model as a tool for patient and clinician education and to train particularly difficult CF bronchoscopies [9]. The lung was initially imaged using low radiation dose computerised tomography with intravenous contrast in full inspiration, these DICOM images were modelled by translation into standard tessellation language files suitable for 3D reconstruction and identification of pulmonary arteries, pulmonary veins, airways, and lung parenchyma separately.…”

mentioning

confidence: 99%

“…In this issue of Journal of Cystic Fibrosis, Mirza et al have published a 3D printed CF lung model as a tool for patient and clinician education and to train particularly difficult CF bronchoscopies [9]. The lung was initially imaged using low radiation dose computerised tomography with intravenous contrast in full inspiration, these DICOM images were modelled by translation into standard tessellation language files suitable for 3D reconstruction and identification of pulmonary arteries, pulmonary veins, airways, and lung parenchyma separately.…”

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confidence: 99%

Biofabrication of personalised anatomical models and tools for the clinic

Allenby

Woodruff

2019

Journal of Cystic Fibrosis

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Biofabrication of personalised anatomical models and tools for the clinic Biofabrication is a rapidly growing research field encompassing imaging, modelling, and printing technologies to produce personalised medical devices for patient anatomies [1,2]. Current cystic fibrosis (CF) treatment personalises physiotherapy and medications based on patient symptoms, genotype, and lifestyle [3]. Biofabrication could further individualise these treatments to CF's unique anatomical presentations, conveniently captured during routine medical imaging. For example, digital biofabrication models may prove useful to simulate and plan treatments, such as calculating dose and delivery of aerosol medications needed to reach the targeted airways. Physical models or personalised therapeutic devices can be rapidly printed into three-dimensional (3D) forms from a diverse array of materials and printing technologies to be leveraged for clinical diagnosis, planning, education, training, and treatment.As the clinical adoption of biofabrication technologies grows, with 3D printing available in 3% of hospitals worldwide in 2017 [4], a concise reference of useful 3D imaging, modelling, and printing technologies will encourage clinical translation. In Table 1, we present a brief biofabrication reference of currently available clinical imaging methods used for patients with CF [5], image modelling software tools used for anatomical reconstruction, analysis, and simulation, and several printing technologies that may be useful for CF anatomical models and medical devices [1,2]. Of specific interest to educational and training models are instrument resolution and cost. Additional enhancements include capturing images at appropriate contrast and the use of multi-material printers that can differentiate various tissue structures in final products. Biofabrication technologies can be used in clinical care as they are able to print biocompatible polymers, ceramics, and metals, as well as extracellular matrix and cells towards providing customised implants within the operating theatre. As a case study, Royal Perth Hospital expanded a popular rapid prototyping service into a medical engineering and physics unit, providing a 5-employee referral service for local and remote clinicians interested in bespoke anatomical models and surgical guides [6], as well as acellular implants [7] and cellularised grafts [8].In this issue of Journal of Cystic Fibrosis, Mirza et al have published a 3D printed CF lung model as a tool for patient and clinician education and to train particularly difficult CF bronchoscopies [9]. The lung was initially imaged using low radiation dose computerised tomography with intravenous contrast in full inspiration, these DICOM images were modelled by translation into standard tessellation language files suitable for 3D reconstruction and identification of pulmonary arteries, pulmonary veins, airways, and lung parenchyma separately. Finally, this 3D digital model was printed using a Stratasys J750, a full-colour 3D printer able to differ...

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3D Printing in the Management of Breast Cancer

Kelil,

Ali

2024

3D Printing at Hospitals and Medical Centers

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3D Printing and the Cystic Fibrosis Lung

Cited by 5 publications

References 5 publications

Imaging properties of 3D printed breast phantoms for lesion localization and Core needle biopsy training

Imaging properties of 3D printed breast phantoms for lesion localization and Core needle biopsy training

Biofabrication of personalised anatomical models and tools for the clinic

3D Printing in the Management of Breast Cancer

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