3D printing collagen/chitosan scaffold ameliorated axon regeneration and neurological recovery after spinal cord injury

Sun, Yan; Yang, Cheng; Zhu, Xu; Wang, Jingjing; Liu, Xiao‐Yin; Yang, Xiping; An, Xingwei; Liang, Jun; Dong, Huajiang; Jiang, Wei; Chen, Chong; Wang, Zhenguo; Sun, Haitao; Tu, Yue; Zhang, Sai; Chen, Feng; Li, Xiaohong

doi:10.1002/jbm.a.36675

Cited by 101 publications

(58 citation statements)

References 42 publications

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“…For application in the CNS, hydrogels have been obtained from chitosan (Chedly et al, 2017), its derivatives as CMC (Xu et al, 2018) and chitosan lactate (Nawrotek et al, 2017), and mixtures with other polymers like gelatin (Gao S. et al, 2014). Biodegradable scaffolds are mainly structured by freeze-drying but can be also obtained by electrospinning, solvent evaporation, supercritical carbon dioxide, and 3D printing (Croisier and Jérôme, 2013;Wang Y. et al, 2018;Sun et al, 2019). For porous scaffolds, many chitosan-blends have been made by combining different biodegradable materials, like gelatin (Wang et al, 2017), collagen (Yan et al, 2019), and PEDOT (Wang S. et al, 2018), among others.…”

Section: Chitosan-based Materials For Tissue Engineering and Regeneramentioning

confidence: 99%

“…Given that the design of the internal structure and surface of the scaffolds is determinant for cell adhesion and proliferation, Sun and collaborators printed a collagen-chitosan 3D scaffold with a specific structure. They observed nerve fibers regeneration and functional recovery after its implantation in rats with spinal cord injury (SCI), showing enhanced therapeutic effects compared with the non-3D-printed material (Sun et al, 2019).…”

Section: Chitosan-based Scaffoldingmentioning

confidence: 99%

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Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Ojeda-Hernández

Canales-Aguirre

Matías‐Guiu

et al. 2020

Front. Bioeng. Biotechnol.

133

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It is well known that the central nervous system (CNS) has a limited regenerative capacity and that many therapeutic molecules cannot cross the blood brain barrier (BBB). The use of biomaterials has emerged as an alternative to overcome these limitations. For many years, biomedical applications of chitosan have been studied due to its remarkable biological properties, biocompatibility, and high versatility. Moreover, the interest in this biomaterial for CNS biomedical implementation has increased because of its ability to cross the BBB, mucoadhesiveness, and hydrogel formation capacity. Several chitosanbased biomaterials have been applied with promising results as drug, cell and gene delivery vehicles. Moreover, their capacity to form porous scaffolds and to bear cells and biomolecules has offered a way to achieve neural regeneration. Therefore, this review aims to bring together recent works that highlight the potential of chitosan and its derivatives as adequate biomaterials for applications directed toward the CNS. First, an overview of chitosan and its derivatives is provided with an emphasis on the properties that favor different applications. Second, a compilation of works that employ chitosan-based biomaterials for drug delivery, gene therapy, tissue engineering, and regenerative medicine in the CNS is presented. Finally, the most interesting trends and future perspectives of chitosan and its derivatives applications in the CNS are shown.

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Section: Chitosan-based Materials For Tissue Engineering and Regeneramentioning

confidence: 99%

Section: Chitosan-based Scaffoldingmentioning

confidence: 99%

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Ojeda-Hernández

Canales-Aguirre

Matías‐Guiu

et al. 2020

Front. Bioeng. Biotechnol.

133

View full text Add to dashboard Cite

show abstract

“…On the flip side, SCI is a disaster that may result in severe motor, sensory, and functional disorders. Implanting biomaterials are actually considered as optimistic approaches to recover neurological functionality [118]. As Bardakova et al [119] exhibited, there are recognized works in which lyophilized CS scaffolds were effectively examined as applicants for spinal cord reproduction.…”

Section: Nerve Regenerationmentioning

confidence: 99%

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

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“…In one study, a new 3D printing technology was used to produce a scaffold with a designed structure. Meanwhile, collagen and chitosan composite materials were used for compatibility and strength balance (Sun et al, 2019b). Joung et al (2018) used 3D printing approach to precisely place iPSC derived spinal cord neuronal progenitor cells (NPCs) and OPCs in a biocompatible scaffold.…”

Section: Technology Of 3d Printingmentioning

confidence: 99%

Polymer-Based Scaffold Strategies for Spinal Cord Repair and Regeneration

Chen

Shu

et al. 2020

Front. Bioeng. Biotechnol.

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The injury to the spinal cord is among the most complex fields of medical development. Spinal cord injury (SCI) leads to acute loss of motor and sensory function beneath the injury level and is linked to a dismal prognosis. Currently, while a strategy that could heal the injured spinal cord remains unforeseen, the latest advancements in polymer-mediated approaches demonstrate promising treatment forms to remyelinate or regenerate the axons and to integrate new neural cells in the SCI. Moreover, they possess the capacity to locally deliver synergistic cells, growth factors (GFs) therapies and bioactive substances, which play a critical role in neuroprotection and neuroregeneration. Here, we provide an extensive overview of the SCI characteristics, the pathophysiology of SCI, and strategies and challenges for the treatment of SCI in a review. This review highlights the recent encouraging applications of polymer-based scaffolds in developing the novel SCI therapy.

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3D printing collagen/chitosan scaffold ameliorated axon regeneration and neurological recovery after spinal cord injury

Cited by 101 publications

References 42 publications

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

Polymer-Based Scaffold Strategies for Spinal Cord Repair and Regeneration

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