3D printing in personalized medicines: A focus on applications of the technology

Bg, Pavan Kalyan; Mehrotra, Sonal; Marques, Shirleen Miriam; Kumar, Lalit; Verma, Ruchi

doi:10.1016/j.mtcomm.2023.105875

Cited by 17 publications

(4 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One previous paper uses 3D printing technology to fabricate a "small contraction" sensor for practical biology work, achieving high-quality and affordable fabrication compared to other technologies [50]. Figure 1 shows a few of the popular 3D printing techniques, which are selective laser sintering (SLS), stereolithography (SLA), fused deposition modeling (FDM), and binder jet printing (BJ) [51].…”

Section: D Printing Techniquesmentioning

confidence: 99%

A Review of Material, Design, and Techniques in 3D Printing for Medical Applications

Ramli,

Mazlan,

Takano

et al. 2023

Int. J. Onl. Eng.

View full text Add to dashboard Cite

This review research assesses the numerous 3D printing methods utilized in medical applications and the materials and design methods that are associated with the current and existing technology. The article thoroughly examines the advantages and disadvantages of various techniques and materials and the difficulties of applying 3D printing technology to the medical sector. Further research and development are required to overcome current challenges since the review highlights the importance of design strategies in achieving positive medical outcomes. Overall, the article provides a thorough overview of the state of 3D printing in medical applications today and its potential to revolutionize the industry.

show abstract

Section: D Printing Techniquesmentioning

confidence: 99%

A Review of Material, Design, and Techniques in 3D Printing for Medical Applications

Ramli,

Mazlan,

Takano

et al. 2023

Int. J. Onl. Eng.

View full text Add to dashboard Cite

show abstract

“…1,8,9 Various 3D printing methods have been explored, including, fused filament fabrication or hot melt extrusion, stereolithography, binder jet printing, inkjet printing, selective laser sintering, and bioprinting. [10][11][12] Recent reviews provide more general and in cases, in-depth, descriptions for 3D printing of medicines 13,14 and non-destructive analyses of 3D printed medicines. 15 Here, we focused on a category of additive manufacturing that encompasses inkjet and related drop-ondemand (DoD) printing techniques/platforms for precision deposition of pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine

Forbes,

Gillen,

Feeney

et al. 2024

Preprint

View full text Add to dashboard Cite

Distributed and point-of-care (POC) manufacturing facilities enable an agile pharmaceutical production paradigm that can respond to localized needs, providing personalized and precision medicine. These capabilities are critical for narrow therapeutic index drugs and pediatric or geriatric dosing, among other specialized needs. Advanced additive manufacturing, 3D printing, and drop-on-demand (DoD) dispensing technologies have begun expanding into pharmaceutical production. We employed a quality by design (QbD) framework to identify critical quality attributes (CQAs), critical material attributes (CMAs), and critical process parameters (CPPs) of a pharmaceutical manufacturing framework that encompasses the production of active pharmaceutical ingredient (API) ‘inks’ at a centralized facility, which are distributed to POC sites for DoD dispensing into/onto delivery vehicles (e.g., orodispersible films, capsules, single liquid dose vials). QbD considerations and cause-and-effect analyses identified the dispensed API quantity and solid state form (CQAs), as well as nozzle diameter, system pressure channel, and number of drops dispensed (CPPs) for detailed investigation. Final assay quantification and content uniformity CQAs were measured from demonstrative levothyroxine sodium single-dose liquid vials of glycerin/water, meeting standard acceptance values. Each POC facility is unlikely to maintain full quality control laboratory capabilities, requiring development of appropriate atline or inline methods to ensure quality control. We developed control strategies, including, atline UV-Vis verification of the API ink prior to dispensing, inline drop counting during dispensing, intermediate atline dispensed volume checks, and offline batch confirmation by LC-MS/MS following production.

show abstract

“…Three-dimensional printing of drugs offers revolutionary advantages, such as the possibility of personalizing patient treatment strategies and combining different drugs and release technologies by easily tailoring dosages based on drug shape, size, and release characteristics [ 1 , 2 , 3 , 4 ]. Currently, the most pharmaceutically attractive aspects of 3D printing include the prospect of developing low-dose drugs with narrow therapeutic windows and increasing the awareness of pharmacogenomics [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Geometry-Driven Fabrication of Mini-Tablets via 3D Printing: Correlating Release Kinetics with Polyhedral Shapes

Kim,

Choi,

Kang

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

The aim of this study was to fabricate mini-tablets of polyhedrons containing theophylline using a fused deposition modeling (FDM) 3D printer, and to evaluate the correlation between release kinetics models and their geometric shapes. The filaments containing theophylline, hydroxypropyl cellulose (HPC), and EUDRAGIT RS PO (EU) could be obtained with a consistent thickness through pre-drying before hot melt extrusion (HME). Mini-tablets of polyhedrons ranging from tetrahedron to icosahedron were 3D-printed using the same formulation of the filament, ensuring equal volumes. The release kinetics models derived from dissolution tests of the polyhedrons, along with calculations for various physical parameters (edge, SA: surface area, SA/W: surface area/weight, SA/V: surface area/volume), revealed that the correlation between the Higuchi model and the SA/V was the highest (R2 = 0.995). It was confirmed that using 3D- printing for the development of personalized or pediatric drug products allows for the adjustment of drug dosage by modifying the size or shape of the drug while maintaining or controlling the same release profile.

show abstract

3D printing in personalized medicines: A focus on applications of the technology

Cited by 17 publications

References 140 publications

A Review of Material, Design, and Techniques in 3D Printing for Medical Applications

A Review of Material, Design, and Techniques in 3D Printing for Medical Applications

Quality by Design Considerations for Drop-on-Demand Point-of-Care Pharmaceutical Manufacturing of Precision Medicine

Geometry-Driven Fabrication of Mini-Tablets via 3D Printing: Correlating Release Kinetics with Polyhedral Shapes

Contact Info

Product

Resources

About